The present disclosure is drawn to inertial pumps. An inertial pump can include a microfluidic channel, a fluid actuator located in the microfluidic channel, and a check valve located in the microfluidic channel. The check valve can include a moveable valve element, a narrowed channel segment located upstream of the moveable valve element, and a blocking element formed in the microfluidic channel downstream of the moveable valve element. The narrowed channel segment can have a width less than a width of the moveable valve element so that the moveable valve element can block fluid flow through the check valve when the moveable valve element is positioned in the narrowed channel segment. The blocking element can be configured such that the blocking element constrains the moveable valve element within the check valve while also allowing fluid flow when the moveable valve element is positioned against the blocking element.

A fermentation and aging apparatus and a method for controlling a fermentation and aging apparatus are provided. The fermentation and aging apparatus may include a tank in which a fluid, such as water may be accommodated, a fermentation container forming a space in which the fluid discharged from the tank may be accommodated, a pump disposed in a channel between the tank and the fermentation container to supply the fluid accommodated in the tank to the fermentation container, a flow rate control valve configured to control a flow rate of the fluid discharged from the tank, a heater configured to heat the fluid discharged from the tank, a temperature sensor configured to measure a temperature of the fluid passing through the heater, and a controller configured to control a degree of opening of the flow rate control valve based on the measured temperature.

A fluid transfer assembly for single use bioreactors includes a fluid transfer housing that can be mounted to the impeller shaft using a bearing that places the fluid transfer assembly directly below the lowest impeller but allows the impeller shaft to spin inside independently of the fluid transfer assembly. A fluid conduit connects the fluid transfer housing to a port in the single use bag wall which allows fluids to be introduced into the sparger and which also helps prevent the fluid transfer assembly from rotating with the impeller shaft.

A full-function artificial organ fitting body comprises a cortex layer and an organ body tissue area. The organ body tissue area comprises a growth area, a differentiation area, a docking area, a branch arterial system, a branch nervous system and a branch venous system. The branch arterial system, the branch nervous system and the branch venous system are distributed in the differentiation area and form a main body three-dimensional skeleton structure with the outer growth area and the middle docking area.

Provided is a high throughput photobioreactor. The high throughput photobioreactor includes: a chamber; a plate installed in the chamber and mounted with a plurality of wells; a plurality of light sources installed in the chamber and irradiating light toward the plate; a light quantity controller positioned on an upper part of the plate to make quantities of light irradiated to the plurality of wells different; and a temperature controller controlling a temperature of the plate.

Reactors, systems and processes for the production of biomass by culturing microorganisms in aqueous liquid culture medium circulating inner loop reactor which utilize nonvertical pressure reduction zones are described. Recovery and processing of the culture microorganisms to obtain products, such as proteins or hydrocarbons is described.

A process for the production of a methane-enriched gas including the steps of providing a bioreactor having at least one device for supplying a gas, and at least one outlet for removing the methane-enriched gas generated in the bioreactor; providing a device for determining the proportion of carbon dioxide in the methane-enriched gas removed from the bioreactor; specifying a target value S for the proportion of carbon dioxide in the methane-enriched gas removed from the bioreactor; supplying carbon dioxide-containing gas to the bioreactor; supplying hydrogen-containing gas to the bioreactor; forming methane-enriched gas in the bioreactor; removing the methane-enriched gas formed in the bioreactor from the bioreactor; determining an actual value for the proportion of carbon dioxide in the methane-enriched gas removed from the bioreactor; comparing the target value S with the determined actual value; regulating the quantity of supplied carbon dioxide-containing gas and/or regulating the quantity of supplied hydrogen-containing gas in a manner such that the determined actual value corresponds to the specified target value S, wherein the target value S specified for the proportion of carbon dioxide in the methane-enriched gas removed from the bioreactor satisfies the condition 0 vol% < S ≤ 5 vol%.

The present disclosure features methods and compositions for increasing the amount of products of cellular metabolism, e.g., proteins, by lowering the temperature of cells expressing the product at one or more steps while culturing the cells, expressing the product, and/or recovering the product.

The invention herein describes a novel photobioreactor (PBR) system for culturing algae. The PBR system utilizes vertical transparent tubes that can be cyclically filled with an algae culture. The vertical tubes further feature pipe pigs deployed therein to disrupt formation of biofilm on the inner walls during the cyclic filling and emptying of the cultures.

A container (10) for receiving biopharmaceutical content (C) in liquid, fluid or gaseous form, includes a peripheral wall (12) that is closed on itself, at least one transfer pipe (22), at least one guiding element (30; 130), and wherein the at least one guiding element (30; 130) includes a gripping member (32; 132) and an attachment member (44; 144). The gripping member (32; 132) and the attachment member (44; 144) are structurally separate and independent of one another and the guiding element (30; 130) has reciprocal assembly elements (60; 160) allowing the structural or functional assembly of the gripping member (32; 132) with the attachment member (44; 144) to ensure the positioning of the gripping member (32; 132) close to the attachment member (44; 144) and the connecting area (46; 146) of the corresponding peripheral wall (12).