A liquid filtration system according to the present invention comprises a bioreactor; a filter configured to filter liquid passing therethrough; a perfusion pump configured to move liquid between the bioreactor and the filter; a liquid line providing fluidic communication between the bioreactor, perfusion pump and filter; and a bleed outlet provided on the liquid line, the bleed outlet configured to provide means to remove liquid selectively from the system under the action of the perfusion pump. With the liquid filtration system according to the present invention, both the filtering and bleed functions may be performed under the action of a single pump, thereby significantly reducing the complexity and cost of the components required.

A group of inventions relates to biotechnology. Disclosed are a printing head and a printing device with fabric spheroids. The printing head includes a system of channels containing input and output channels, upper and lower channels for separation of nutrient medium, as well as a channel for a supporting plunger. Inlet channel has diameter providing movement of spheroid on it only by one. Output channel has diameter not less than diameter of inlet channel, includes input hole for input of printing tool and outlet hole for output of spheroids. Separation channels are made with possibility of connection of nutrient removal device with outlet channel through system of microchannels. Device includes a printing head, a device for feeding spheroids with a nutrient medium into an inlet channel, a device for removal of nutrient medium, a supporting plunger, a printing tool, a system for recording position of the spheroid in the output channel and a computing device for control. Inventions provide higher accuracy of positioning of spheroid on printed surface, improved quality of production of three-dimensional structures and faster printing.

A cell-scaffold device includes at least one channel network including an inlet, a plurality of channels include a parent channel having an end portion communicating with the inlet and another end portion communicating with a first bifurcation, forming two child channels. Each child channel has an end portion communicating with a respective end portion of the first bifurcation and another end portion communicating with a second bifurcation, forming two grand-child channels from each child channel. Each grand-child channel has an end portion communicating with a respective end portion of the second bifurcation and another end portion. The other end portion of the grand-child channel either forms an outlet or a third child channel in communication with the grand-child channel. Each forming of grand-child channels defines a generation of the fractal structure. The devices are of use as scaffolds for seeding, growing, and maintaining cells implanted in and/or on the device.

The apparatuses described herein relate to preparation of a meat product. Apparatuses, systems comprising the apparatuses, and methods of making and use the systems and apparatuses are described herein. These are useful for controlling one or more of growth on and separation of a meat product from an enclosed substrate. The apparatuses and systems are configured to receive fluid and grow the meat product and/or separate the meat product from the substrate in a scalable manner.

A microorganism collection device comprises: (a) a base, the base comprising (i) a reservoir comprising a bottom and a side wall extending up from the bottom, (ii) a culture medium within the reservoir, the culture medium disposed upon the bottom of the reservoir and comprising a top surface that is elevated from the bottom higher than the side wall of the reservoir, (iii) a first tab extending laterally outward relative to the reservoir; and (b) a lid comprising (i) an associated state where the lid is covering the culture medium and (ii) a dissociated state where the lid is separated from the base and not covering the culture medium.

Disclosed herein are platforms, systems, and methods including a cell culture system that includes a cell culture container comprising a cell culture, the cell culture receiving input cells, a cell imaging subsystem configured to acquire images of the cell culture, a computing subsystem configured to perform a cell culture process on the cell culture according to the images acquired by the cell imaging subsystem, and a cell editing subsystem configured to edit the cell culture to produce output cell products according to the cell culture process.

A deepwater photobioreactor system including a vertical stack extending between an ocean surface and an ocean floor. The vertical stack includes an inlet conduit and an outlet conduit where the inlet conduit is arranged to transport at least seawater and the outlet conduit is arranged to transport at least a biomass. The system includes a first photobioreactor in fluid communication with the inlet conduit and the outlet conduit that is connected to the vertical stack via the inlet and outlet conduits at a first position along the vertical stack below the ocean surface. The first bioreactor is arranged to cultivate the biomass. The system also includes a mooring system arranged to anchor the vertical stack to the ocean floor and arranged to receive the biomass via the outlet conduit and output the biomass to a harvest pipeline.

This new artificial intelligence application identifies micro-organisms, matter and contaminates from the bottom of lakes, rivers, harbors, streams and any other large bodies of water utilizing conveyor belts with and without embedded microscope slides, watertight containers, high definition lenses, drones, robots, artificial intelligence and machine learning algorithms. The AI application can be used below and above the surface of water. The AI command center utilizes a gorilla glass panel to manipulate by finger or hand to be viewed clearly by the human eye the matter, microbes and contaminates on the glass before and after they have been analyzed by the algorithms and servers.

A system for dissociating cells from a cell culture vessel. The system comprises an imaging system configured to image a plurality of cells in a cell culture vessel being dissociated from at least one surface of the cell culture vessel by at least one cell dissociation agent; and at least one controller coupled to the imaging system and configured to: control the imaging system to capture a sequence of images of at least some cells in the plurality of cells during dissociation; and identify when to neutralize the at least one cell dissociation agent using the sequence of images.

Provided is a cell tissue producing method including: a cell adhesive portion forming step of forming a cell adhesive portion formed of a cell adhesive material and having a predetermined shape at a predetermined position over a substrate having a cell non-adhesive surface; and a cell locating step of discharging a cell suspension containing at least cells and a cell drying inhibitor onto the cell adhesive portion in the form of a liquid droplet to locate the cells.