A campus for fabricating at least one pharmaceutical product has one or more customizable facilities each configured to manufacture the at least one pharmaceutical product, a media/buffer plant, and a utility building connected by a utility line to the media/buffer plant and/or the one or more customizable facilities to provide at least one first utility to the media/buffer plant and/or the one or more customizable facilities via the utility line.

Aspects relate to an automated cell culture incubator and to methods for using such an incubator. In one aspect, the cell culture incubator includes an incubator cabinet having a transfer chamber and an internal chamber that are arranged to form an airlock configuration. In some embodiments, objects placed into the incubator cabinet are sterilized using ozone produced by an ozone generator. The incubator may include one or more transfer devices that move objects between the transfer chamber and the internal chamber.

The invention relates to a tubing device for sterile media including a container for storing sterile media, a discharge port for discharging liquid sterile media, an inlet port for introducing fluid into the tubing device and a multiple-way-connector. The multiple-way-connector is connected to the container, the discharge port, the inlet port, and an apparatus for preparing, mixing and discharging a sterile medium for use with a tubing device, including a water inlet port for introducing water, a water outlet port configured to be connected to the inlet port of the tubing device, a fluid pump for conveying the fluid, the fluid pump is connected to the fluid inlet port and the water outlet port and a container support for supporting the container of the tubing device.

To provide a transfer chamber capable of replacing a chemical filter without affecting an internal atmosphere, and shortening or eliminating stop time of a transfer process of a wafer (W) associated with replacement of the chemical filter. The transfer chamber transfers the wafer (W) to or from a processing device (6) by using a transfer robot (2) provided thereinside, and includes a circulation path (CL1) formed inside of a transfer chamber (1) to circulate gas, a chemical filter unit (7) provided in the midstream of the circulation path (CL1), and a connecting and disconnecting means (8) which switches connection and disconnection of the chemical filter unit (7) to and from the circulation path (CL1).

A liquid feed device that feeds a liquid medium and a cell suspension to target containers by respectively suited liquid feed methods is provided. A pump 6 is connected between a first liquid bottle 12 containing a liquid medium and a second liquid bottle 2 containing a cell suspension, and a receptacle 8 to be used as a culture container is connected downstream of a second liquid bottle 12. The liquid medium in the first liquid bottle is sent to the receptacle through the pump 6 and a branch point 20 by opening a first supply valve 17, and the cell suspension in the second liquid bottle is sent to the receptacle by opening a first gas introducing valve 10, a second gas introducing valve 15, and a second supply valve 19 and transferring, by pressure, a gas supplied from the first gas introducing valve 10 to the second liquid bottle through the pump 6 and a branch point 16.

The present invention relates to a bioprocess bag 118 comprising a bag wall defining an enclosed volume for holding biomaterials. The bag wall comprises at least one inlet port 142 and at least one outlet port 146. The bioprocess bag 118 also comprises a tube structure 400 comprising a first opened-end proximate the bag wall and a second distal end, the tube extending into the enclosed volume, and the tube structure 400 comprising a reinforced portion 402 proximate the first opened-end.

A system capable of a germicidal treatment of highly opaque liquids, featuring a filter, which prevents wavelengths above the UV-C spectrum reaching the liquid being treated, one or more spiral-shaped tubes extending from an inlet end to an outlet end creating a fluidic pathway, and one or more light sources illuminating the one or more spiral-shaped tubes, wherein the one or more light sources emit light in a wavelength range between 180-300 nm.

A campus for fabricating at least one pharmaceutical product has one or more customizable facilities each configured to manufacture the at least one pharmaceutical product, a media/buffer plant, and a utility building connected by a utility line to the media/buffer plant and/or the one or more customizable facilities to provide at least one first utility to the media/buffer plant and/or the one or more customizable facilities via the utility line.

A culture container linkage device according to the present disclosure includes a first actuator configured to advance or retract needles 32, an actuator holder rotatably provided on a frame and configured to hold the first actuator, a second actuator, and a washer configured to wash the needles. The second actuator rotates the needles via the actuator holder. The needles are configured to be positioned, by the second actuator, at a container-facing position at which the needles face a culture container and a washing-facing position at which the needles face the washer.

Disclosed are a process and an automated facility for manufacturing a purified protein of interest. The protein of interest can be a recombinant or naturally occurring protein and/or a therapeutic or other medically useful protein. For example, the disclosed process and automated facility are useful for manufacturing a purified protein drug substance.