In an illustrative embodiment, automated multi-module cell editing instruments are provided to automate multiple edits into nucleic acid sequences inside one or more cells.

In an illustrative embodiment, automated multi-module cell editing instruments are provided to automate multiple edits into nucleic acid sequences inside one or more cells.

Provided is a novel production system that does not involve, or can minimize, the transport of liquid ammonia in the production of an organic compound or the production of a microorganism by microbial fermentation. A production system for an organic compound or a microorganism includes: an ammonia synthesis apparatus in which an ammonia-containing gas is synthesized by reaction of a source gas containing hydrogen and nitrogen in the presence of a supported ruthenium catalyst; and a culture apparatus that cultures a microorganism having organic compound productivity using ammonia originating from the ammonia-containing gas obtained by using the ammonia synthesis apparatus.

The present invention relates to improved processes and systems for purification of biological molecules, where the processes can be performed in a continuous manner.

A wood chip fermentation device includes: a chip fermenter 11 that is charged with wood chips serving as a heat source and that ferments the wood chips; a temperature sensor 11a that is provided inside the chip fermenter 11 and measures the temperature inside the chip fermenter; a thermal energy extracting pipe 12 that is disposed inside the chip fermenter and extracts fermentation heat from inside the chip fermenter; a pump section 13 that supplies a medium to or takes out a medium from the thermal energy extracting pipe 12; a stirring blade 14a that stirs wood chips 10a put in the chip fermenter 11; and a discharge conveyor 15 that is disposed at a lower portion of the chip fermenter 11 and discharges fermented material. The stirring blade 14a is disposed between the thermal energy extracting pipes 12 and a rotating surface thereof is in a state of being parallel to the thermal energy extracting pipes 12. A bottom surface of the chip fermenter 11 is formed in an arcuate shape such as to follow the rotating outer peripheral surface of the stirring blade 14a. A plurality of temperature sensors 11a are installed in a vertical direction inside each chip fermenter. Control of an on-off valve of the thermal energy extracting pipe 12 is performed based on temperature information from the temperature sensors 11a.

In an illustrative embodiment, automated multi-module cell editing instruments are provided to automate multiple edits into nucleic acid sequences inside one or more cells.

Provided is a novel production system that does not involve, or can minimize, the transport of liquid ammonia in the production of an organic compound or the production of a microorganism by microbial fermentation. A production system for an organic compound or a microorganism includes: an ammonia synthesis apparatus in which an ammonia-containing gas is synthesized by reaction of a source gas containing hydrogen and nitrogen in the presence of a supported ruthenium catalyst; and a culture apparatus that cultures a microorganism having organic compound productivity using ammonia originating from the ammonia-containing gas obtained by using the ammonia synthesis apparatus.

The present invention provides an apparatus and a method which are suitable for producing an organic substance using a synthesis gas from a waste gasification furnace. The apparatus 1 for producing an organic substance from waste comprises a synthesis gas generation furnace 11 for generating a synthesis gas by partial oxidation of the waste; and an organic substance production unit 12 for producing an organic substance from the synthesis gas. The organic substance production unit 12 further comprises: a synthesis unit 13 for synthesizing an organic substance by subjecting the synthesis gas to catalytic reaction in the presence of a metal catalyst, and a fermenter 14 for producing an organic substance by subjecting the synthesis gas to microbial fermentation.

The current disclosure concerns a system for producing biomolecules comprising a bioreactor including a chamber (1) suitable for receiving a liquid comprising cells and viral particles; and a concentrator (2), wherein said concentrator is equipped with a retentate conduit (300, 303) suitable for collecting said retentate and facilitating recirculating of the retentate to an input of said bioreactor or to an input of an intermediate vessel (4) positioned between said concentrator and said bioreactor. In a second and third aspect the disclosure concerns a method for producing biomolecules and the use of the disclosed system for the production of biomolecules.

In an illustrative embodiment, automated multi-module cell editing instruments are provided to automate multiple edits into nucleic acid sequences inside one or more cells.