The present invention relates to a nanocoil-substrate complex for controlling adhesion and differentiation of stem cells, a manufacturing method thereof, and a method of controlling adhesion and differentiation of stem cells by using the nanocoil-substrate complex, and the method of controlling adhesion and differentiation of stem cells may temporally and reversibly control adhesion and phenotypic differentiation of stem cells in vivo and ex vivo by controlling application/non-application of a magnetic field to the nanocoil-substrate complex.

The present invention relates to a composite membrane. The composite membrane includes: an elastic polymer substrate having a first surface processed by a surface modification; and a thermosensitive conductive layer formed on the first surface by performing a co-polymerization process, allowing an electrical current to pass through, and altering a hydrophilicity of a membrane surface in response to a change of a temperature.

A method and device for preferentially delivering a compound such as an antigen to the cytosol of an immune cell. The method comprises passing a cell suspension comprising the target immune cell through a microfluidic device and contacting the suspension with the compound(s) or payload to be delivered.

Provided herein are methods of culturing a mammalian cell and various methods that utilize these culturing methods. Also provided are multi-well cell culture plates, e.g., for use in perfusion culturing methods.

The present invention relates to a method for enhancing production of autologous genetically engineered T cells for use in cell therapy applications.

The present invention provides methods and systems for modulating antibody production by passing a cell suspension through a constriction, wherein the constriction deforms the cell thereby causing a perturbation of the cell such that a compound that modulates antibody production enters the cell. In some embodiments, the invention provides methods and systems for inducing de novo antibody production in cells.

Methods of preparing red blood cell mimetics and functionalized red blood cell mimetics, and methods of making and using those mimetics, are provided.

Provided herein are methods for generating stem cell-derived retinal pigment epithelial monolayer cultures as well as methods of using the same. Also provided are populations of retinal pigment epithelial cells prepared according to these methods. In addition, three-dimensional tissue products derived from human induced pluripotent stem cells are also provided along with methods of making and using the same.

Disclosed herein are contractile cell constructs, methods for using them to treat disease, and methods for making them.

The invention relates a method for producing a pharmaceutical composition, comprising the steps of: providing a liquid collected from a mammal, which liquid comprises cellular constituents of blood, providing a container having an internal surface, contacting said liquid with said internal surface, incubating said liquid contacted with said internal surface for an incubation time, wherein said liquid is agitated with an agitation means at least once during said incubation time, and after said incubation time has passed, obtaining said pharmaceutical composition by steps comprising (1) collecting said liquid or (2) removing part of or the entirety of said cellular constituents from said liquid and collecting the remainder.