An object of the present invention is to provide a method for producing a sheet-like cell structure having excellent strength and shape-maintaining performance, and a sheet-like cell structure having excellent strength and shape-maintaining performance. According to the present invention, there is provided a method for producing a sheet-like cell structure, including: a step of adding a biocompatible macromolecular block, a cell, and a liquid medium onto a culture support body having a plurality of recessed portions on a culture surface, and immersing the biocompatible macromolecular block and the cell in uppermost portions of the recessed portions; and a step of culturing the cell to obtain a sheet-like cell structure.

A method of preparing and obtaining cell aggregates having increased oxygenation abilities. The method includes the preparation of fluorinated polymeric microparticles. Once the fluorinated polymeric microparticles are prepared, they are combined with mammalian cells to create the cell aggregates having increased oxygenation.

A matrix for the cultivation of biological cells and differentiation into neuronal cells consists of a polymer base body having a structured surface with a microstructure and a nanostructure embedded therein.

A cell adhesive substrate comprising a substratum, on a surface of which a peptide group is immobilized, wherein the peptide group comprises a peptide containing 40% or more and 75% or less of one or two or more of basic amino acid residues selected from the group consisting of lysine, arginine and histidine and 25% or more of one or two or more of hydrophobic amino acid residues selected from the group consisting of leucine, isoleucine, glycine, alanine, valine, phenylalanine, proline, tryptophan and methionine. There is provided a cell adhesive substrate that is unlikely to cause an immune reaction and can maintain a cell adhesion effect for a long time.

Provided are a culture scaffold for promoting stem cell differentiation comprising a multilayer graphene film, a method of regulating growth and differentiation of a stem cell using the culture scaffold, and a method of preparing the culture scaffold, where the culture scaffold is capable of promoting the osteogenic differentiation of stem cells as a result of laminating a graphene film without comprising an additional substance, and it may be variously applicable to application fields of stem cells in/outside the body.

The present invention discloses a method of forming high-strength composite sheets composed of a fiber-reinforced biological matrix. This invention discloses three aspects of technology: fiber placement, biological matrix growth, and material insertion within a biological matrix. A cell culture is grown in a tank of nutrients. The cells form a skin and can envelope fibers that are positioned at a specific location. When taken out of its solution, it dries pinning the fibers into the sheet to form a lightweight, waterproof layer. By creating mostly axial fibers and rolling them into a tube, extremely strong structural cylinders can be formed. By incorporating a mesh of fibers (woven or knit) an extremely tough layer is formed that can be stacked and made into ballistic armor. The addition of foreign additives; graphite, metal powder may increase the strength, performance, and conductivity of the material.

This invention relates to live cell constructs for in vitro and/or ex vivo production of cultured milk products from mammary cells, methods of producing isolated cultured milk products from mammary cells, bioreactors for producing isolated cultured milk products, and cultured milk products.

Described is a composite material composed of an atomically thin (single layer) amorphous carbon disposed on top of a substrate (metal, glass, oxides) and methods of growing and differentiating stem cells.

This invention relates to improved methods of genetically modifying animal cells by decreasing the distance between cells and genetic modification agents in order to increase the efficiency of genetic modification and/or reduce use of gene modification agents.

The present invention provides hollow microcarriers for cell culture. The hollow microcarriers form a shell around a hollow interior and can be opened to permit cell infiltration or harvesting. The hollow microcarriers protect cells from hydrodynamic shear stress without hindering the diffusion of nutrients in and out of their hollow interior.