Patent classifications
C30B7/00
Methods and systems relating to the selection of substrates comprising crystalline templates for the controlled crystallization of molecular species
The present invention generally relates to methods and systems relating to the selection of substrates comprising crystalline templates for the controlled crystallization of molecular species. In some embodiments, the methods and systems allow for the controlled crystallization of a molecular species in a selected polymorphic form. In some embodiments, the molecular species is a small organic molecule (e.g., pharmaceutically active agent).
Apparatus and methods for lipidic cubic phase (LCP) injection for membrane protein investigations
An injector apparatus and methods for use, where the injector apparatus comprises: (a) hydraulic stage having first and second ends and including a housing defining a cavity, a primary plunger disposed in the cavity and a secondary plunger, (b) a pressurization system coupled to the hydraulic stage's first end, where the primary plunger is in fluid communication with the pressurization system and is in mechanical communication with the secondary plunger, (c) a reservoir bore defined in the hydraulic stage housing and configured to receive the primary plunger's second end, where the secondary plunger is disposed within the reservoir bore and (d) a nozzle assembly including a housing, a gas tube and a nozzle capillary, where the nozzle capillary is partially disposed in and is substantially coaxial with the gas tube, where the nozzle capillary's first end is in fluid communication with the reservoir bore's second end.
Apparatus and methods for lipidic cubic phase (LCP) injection for membrane protein investigations
An injector apparatus and methods for use, where the injector apparatus comprises: (a) hydraulic stage having first and second ends and including a housing defining a cavity, a primary plunger disposed in the cavity and a secondary plunger, (b) a pressurization system coupled to the hydraulic stage's first end, where the primary plunger is in fluid communication with the pressurization system and is in mechanical communication with the secondary plunger, (c) a reservoir bore defined in the hydraulic stage housing and configured to receive the primary plunger's second end, where the secondary plunger is disposed within the reservoir bore and (d) a nozzle assembly including a housing, a gas tube and a nozzle capillary, where the nozzle capillary is partially disposed in and is substantially coaxial with the gas tube, where the nozzle capillary's first end is in fluid communication with the reservoir bore's second end.
Highly reflective crystalline colloidal arrays with radiation absorbing particles
A radiation-scattering composition, comprising a plurality of colloidal crystals or aggregates of colloidal crystals, each said crystal comprising radiation reflecting particles in a colloidal array and radiation absorbing particles dispersed in the crystals. The composition scatters radiation in a wavelength band in substantially all directions and absorbs radiation.
Highly reflective crystalline colloidal arrays with radiation absorbing particles
A radiation-scattering composition, comprising a plurality of colloidal crystals or aggregates of colloidal crystals, each said crystal comprising radiation reflecting particles in a colloidal array and radiation absorbing particles dispersed in the crystals. The composition scatters radiation in a wavelength band in substantially all directions and absorbs radiation.
Nano-Particles Containing Carbon and a Ferromagnetic Metal or Alloy
The invention relates to nano-particles comprising metallic ferromagnetic nanocrystals combined with either amorphous or graphitic carbon in which or on which chemical groups are present that can dissociate in aqueous solutions.
According to the invention there is provided nano-particles comprising metal particles of at least one ferromagnetic metal, which metal particles are at least in part encapsulated by graphitic carbon.
The nano-particles of the invention are prepared by impregnating carbon containing bodies with an aqueous solution of at least one ferromagnetic metal precursor, drying the impregnated bodies, followed by heating the impregnated bodies in an inert and substantially oxygen-free atmosphere, thereby reducing the metal compounds to the corresponding metal or metal alloy.
Experiment system and method for accurate controlling of macromolecular crystallization process
An experiment system and method for accurate controlling of macromolecular crystallization process. The system has a platform-equipped horizontal moving slot and channel dedicated backwash module, a droplet adding control module, an observing module, a user observation computer system, and an experimental condition control module. A high-precision movement knob of the x-axis platform and the y-axis platform of the system and the accurate position control of a syringe needle are used to ensure that the macromolecular solution can be added into the correct positions of convex or concave. The crystallization induction period of the target crystal form is determined by the real-time data of the high-speed microcamera, and the crystal cultivation environment is adjusted in real time. This is simple and easy to operate, high in productivity, can be applied to the conventional experimental replication.
METHOD FOR PRODUCING AMINO ACID CRYSTALS AND METHOD FOR PRODUCING PROTEIN CRYSTALS
The object of the present invention is to provide a new application of an optical vortex.
For the object, a method for producing crystalline amino acid comprises a step of irradiating a saturated solution of amino acid with optical vortex, and depositing crystalline amino acid in the saturated solution of amino acid.
In the method, it is desirable that the amino acid contains at least one of alanine, arginine, asparagine, asparagine acid, cysteine, glutamine, glutamine acid, glycine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, valine, and derivative of them.
HYDROTHERMAL METHOD FOR GROWTH OF ALKALINE EARTH METAL STANNATE BULK SINGLE CRYSTALS AND CRYSTALS FORMED THEREBY
Hydrothermal methods for the synthesis of bulk crystals of alkaline earth metal stannates are described. Methods can be utilized for growth of large, single crystals of alkaline earth metal stannates including fully cubic BaSnO.sub.3 and SrSnO.sub.3.
BIOPOLYMER CONCENTRATION METHOD, CRYSTALLIZATION METHOD, AND NANOSTRUCTURED SUBSTRATE
Electromagnetic waves are uniformly distributed on the light-receiving surface side by taking advantage of their property of being easily concentrated in sharp parts, and the front area (S.sub.A) on the emission surface side is made larger than the back area (S.sub.B) on the light-receiving surface side (S.sub.A/S.sub.B>1), thereby forming a more moderate electric field region. A reduced gold fine particle group (average particle size: 20 nm) was self-assembled on a transparent polyester resin film and half-submerged and fixed. This base material was repeatedly immersed in an electroless gold plating solution so that gold particles were deposited on the gold fine particles. 10 microliters of a protein solution was added dropwise to this nanostructured substrate, and crystallized by a hanging drop vapor diffusion method.