Provided herein are polypeptides that bind to a transferrin receptor, methods of generating such polypeptides, and methods of using the polypeptides to target a composition to a transferrin receptor-expressing cell.

Provided herein are polypeptides that bind to a transferrin receptor, methods of generating such polypeptides, and methods of using the polypeptides to target a composition to a transferrin receptor-expressing cell.

The invention relates to novel molecules and libraries thereof as well as methods for their production. Methods of producing the novel molecules include the cleaving of starting molecules into molecular subunits and the assembly of the subunits into novel recombined molecules.

De novo synthesized large libraries of nucleic acids are provided herein with low error rates. Further, devices for the manufacturing of high-quality building blocks, such as oligonucleotides, are described herein. Longer nucleic acids can be synthesized in parallel using microfluidic assemblies. Further, methods herein allow for the fast construction of large libraries of long, high-quality genes. Devices for the manufacturing of large libraries of long and high-quality nucleic acids are further described herein.

The present invention relates to a method for producing a population of nucleic acids encoding at least one protein comprising at least one immunoglobulin variable domain having a non-human-derived CDR3 amino acid sequence embedded in essentially human framework sequences, as well as to a population of nucleic acids and a population of proteins relates thereto and uses thereof.

The present invention relates to a method for producing a population of nucleic acids encoding at least one protein comprising at least one immunoglobulin variable domain having a non-human-derived CDR3 amino acid sequence embedded in essentially human framework sequences, as well as to a population of nucleic acids and a population of proteins relates thereto and uses thereof.

The present invention concerns a method for sequentially attaching a plurality of oligonucleotides to nucleic acids to produce barcoded nucleic acids, wherein the nucleic acids are obtained from a plurality of cells, wherein the plurality of cells are in a plurality of microcapsules, each microcapsule comprising a semi-permeable shell and a core.

The present invention concerns a method for sequentially attaching a plurality of oligonucleotides to nucleic acids to produce barcoded nucleic acids, wherein the nucleic acids are obtained from a plurality of cells, wherein the plurality of cells are in a plurality of microcapsules, each microcapsule comprising a semi-permeable shell and a core.

The present disclosure provides systems and methods for preparing a DNA library from a sample comprising shelf-stable lyophilized microspheres comprising DNA library preparation reagents providing a streamlined workflow for DNA library preparation. The present disclosure also provides a smart consumable container for collecting and transporting the sample.

The present disclosure provides systems and methods for preparing a DNA library from a sample comprising shelf-stable lyophilized microspheres comprising DNA library preparation reagents providing a streamlined workflow for DNA library preparation. The present disclosure also provides a smart consumable container for collecting and transporting the sample.