The present disclosure relates to compositions, devices, and methods for delivery of protein therapeutics, e.g., intravitreal delivery of a protein therapeutic to the eye. In particular, the present disclosure describes drug-delivery devices for injection into the eye of a subject in need thereof comprising a capsule having a bi-layered wall and a therapeutic agent, wherein the therapeutic agent is initially present within a luminal space of the capsule. Methods of making and using these drug-delivery devices are also described.

The present disclosure is directed to an implantable therapeutic delivery device. This device comprises a hydrogel core; one or more therapeutic agents suspended within the hydrogel core; and an elongated nanofibrous substrate having proximal and distal ends, said nanofiber substrate having an interior nanofiber wall defining an internal space that extends longitudinally between the proximal and distal ends of the substrate, wherein the hydrogel core comprising the one or more therapeutic agents is positioned within the internal space. The disclosure is also directed to methods of delivering a therapeutic agent to a subject in need thereof that involves implanting the device described herein.

This three-dimensional knitted textile insert is obtained in a single step by warp knitting technology, on a double-needle Raschel machine or on a crocheting machine. It includes in the production direction at least two tubes extending parallel to one another, and separated from one another by a binding area at the level of which the sheets resulting from the knitting are interlinked.

A face mask includes a piece of fabric including a main body portion, a first leg extending from first side of the main body portion, and a second leg extending from a second side of the main body portion. A first plurality of slots are arranged along a first side perimeter of the main body portion, and a second plurality of slots are arranged along a second side perimeter of the main body portion. At least one first fold in the piece of fabric extends between the first plurality of slots and at least one second fold extends between the second plurality of slots. The first plurality of slots are aligned and the first leg extends through the first plurality of slots. The second plurality of slots are also aligned and the second leg extends through the second plurality of slots.

The present invention relates to the field of biomaterials, more particularly to the field of poly(alkyl cyanoacrylate) based nano- and microfibers. The present invention provides a novel method for producing ready-to-use poly(alkyl cyanoacrylate) based nano/microfibers, wherein the method comprises electrospinning of poly(alkyl cyanoacrylate) homopolymers or copolymers generated by anionic polymerization of alkyl cyanoacrylate monomers or oligomers and characterized by a specific polydispersity index. Accordingly, the present invention also provides novel ready-to-use nano/microfibers obtainable by the method as well as uses thereof, including (therapeutic) biomedical applications such as wound healing, drug delivery and tissue regeneration and engineering.

The invention relates to a method for manufacturing a dialysis filter comprising fluorine-containing hollow fiber membranes, the fluorine-containing hollow fiber membranes being made by a method comprising at least steps (A) to (C): (A) preparing a spinning solution comprising an aprotic solvent, a hydrophobic base polymer, a hydrophilic polymer, and a fluorine-comprising surface modifying macromolecule in a concentration less than 1.12% w/w; (B) extruding said spinning solution from an outer annular orifice through a tube-in-orifice spinneret into an aqueous solution, and (C) isolating the formed hollow fiber membrane,
characterized in that the manufacturing of the dialysis filter comprises a steam sterilization procedure. The invention is further related to dialysis filter comprising a fluorine-containing hollow fiber membrane comprising a hydrophobic base polymer, a hydrophilic polymer and a fluorine-comprising surface modifying macromolecule in a concentration less than 3.6% w/w, based on the total weight of the fluorine-containing hollow fiber membrane.

The present invention relates to a fine dust mask, and more particularly, to an antibacterial fine dust mask. The fine dust mask according to the present invention comprises: a mask part; a sealing member fixed to the top of the inner surface of the mask part; and a fine dust filter sheet positioned between the inner surface of the mask part and a user's face.

Pre-dosed wipes and packaged systems of such wipes including a nonwoven substrate formed from natural pulp fibers and synthetic thermoplastic binder fibers comprising at least one of a biodegradable and/or compostable polyester, polyvinyl alcohol (PVOH), or polyvinyl acetate (PVA). The binder fibers, and the nonwoven substrate as a whole may meet any applicable biodegradability/compostability standard (e.g., ASTM D6400 or EN13432). The wipe may be substantially void of PLA. The fibers and/or nonwoven substrate may be meltblown, spunbond, spunlaid, SMS (spunbond-meltblown-spunbond), coformed, carded web, thermal bonded, thermoformed, spunlace, hydroentangled, hydroembossed, needled, or chemically bonded. A cleaning composition is loaded onto the wipe. A container can be provided within which the plurality of nonwoven substrates pre-dosed with the cleaning composition are packaged.

The present invention discloses a braided silk scaffold with adjustable mechanical and degradation properties, and a preparation method and use thereof, belonging to the field of three-dimensional scaffold materials for tendon/ligament repair. The preparation method includes braiding at least one silk strand to form a silk core; placing 1-6 bundles of silk cores in a braiding machine, and braiding at least one layer of silk cladding on the surface of the silk cores to form a silk base frame; removing sericin from the silk base frame; soaking the silk base frame in a collagen solution with a concentration of 3-20 mg/ml, and cross-linking the silk base frame in a vacuum thermal cross-linking machine to obtain the silk scaffold. The braided silk scaffold with adjustable mechanical and degradation properties according to the present invention has good mechanical properties and biocompatibility.

A wettable SMS material for personal protective equipment, such as a SMS fabric that has been treated to improve the wettability and absorbency properties of the SMS fabric is provided. A treated SMS fabric for personal protective equipment can retain its durability, breathability, and comfort, and may also provide the fabric with wettability and absorption properties. An article for personal protective equipment formed from a wettable SMS fabric is also provided.