Methods of using split G-quadruplexes associated with functional tags for associating said tags to target nucleic acids. Methods include use of split G-quadruplexes associated with detection tags for the detection of target nucleic acids, and use of split G-quadruplexes associated with capture tags for detection or capture of target nucleic acids.

Example aspects of a sliding disc assembly for a dual spring valve, and a method of operating a dual spring valve are disclosed. The sliding disc assembly can comprise a shaft defining a first end and a second end; a disc mounted on the shaft between the first end and the second end, the disc defining an upper disc surface, a lower disc surface, and an annular base surface; a first spring mounted on the shaft between the lower disc surface and the first end of the shaft; and a second spring mounted on the shaft between the upper disc surface and the second end of the shaft, wherein the first spring defines a spring force that is different from a spring force of the second spring.

A valve assembly for a tire inflation/deflation system includes a body having a control port and a tire port, and a valve member for fluidly connecting or disconnecting the control port with the tire port. In one embodiment, the valve includes a fluid-operated damper having a damper chamber for controlling a timing of the valve member. A vent valve is provided for permitting excess fluid pressure to escape from the damper chamber. In another embodiment, the valve member includes a diaphragm separating first and second fluid chambers. A vent passage and at least one resilient fluid pressure-operated valve element are provided for enabling fluid to vent from the first chamber to the second chamber. Multiple-redundant valve elements may be provided to form an isolation gap that restricts contamination of the valve assembly.

The invention relates to a double articulated device and system comprising at least one active element provided with an edge (M), with two points (M1) and (M2), where (M1) is different from (M2), a rotating element connected to the edge (M) and a rotating fixture positioned in the point (M1) of the edge (M) and connected to the rotating element, in which, during actuation, the active element simultaneously describes a rotational movement with an angle β around the rotating element, and a partial pivoting movement in the vertical plane around the rotating fixture, so that the point (M2) of the edge (M) describes an angle a between a value α.sub.max corresponding to the “open” position ES0 and a value α.sub.min which corresponds to an ES1 “closed” position of the device.

A damping valve includes a damping valve body with an annular groove which has a base and which is limited by an inner valve seat surface and an outer valve seat surface for at least one valve disk. The base of the annular groove has a maximum distance from the valve seat surface along a circumferential area and has a minimum axial distance from the valve seat surface in another circumferential area.

A damping valve includes a damping valve body with an annular groove which has a base and which is limited by an inner valve seat surface and an outer valve seat surface for at least one valve disk. The base of the annular groove has a maximum distance from the valve seat surface along a circumferential area and has a minimum axial distance from the valve seat surface in another circumferential area.

Embodiments of air admittance valve assembly and plumbing system incorporating the same are provided herein. In some embodiments, a valve assembly to allow or stop a flow for use with enclosed environment includes a housing having, an inlet disposed at a first end of the housing fluidly coupled to environment surrounding housing, an outlet disposed at a second end of housing fluidly coupled to enclosed environment, and an interior volume divided into a first zone, a second zone, and a third zone; a first valve having a first valve seat and a first sealing member urged by an existing force between a closed or open position; and a second valve having a second valve seat and a second sealing member urged by an existing force between a closed or open position.

The invention is directed to a valve actuating device comprising a body with a bore and a bottom, an actuating element sealingly housed in the bore of the body and forming a first chamber with the body, a piston sealingly extending through a bore in the actuating element, the piston and bore delimiting a second actuating chamber, a passage for an auxiliary fluid between the first and second chambers so that a movement of the piston in the bore of the actuating member can increase the pressure in the first chamber and move the actuating element. The fluid passage comprises a restriction and a check-valve, both arranged in parallel, so as to limit the flow of the auxiliary fluid from the second chamber to the first chamber.

The invention is directed to a valve actuating device comprising a body with a bore and a bottom, an actuating element sealingly housed in the bore of the body and forming a first chamber with the body, a piston sealingly extending through a bore in the actuating element, the piston and bore delimiting a second actuating chamber, a passage for an auxiliary fluid between the first and second chambers so that a movement of the piston in the bore of the actuating member can increase the pressure in the first chamber and move the actuating element. The fluid passage comprises a restriction and a check-valve, both arranged in parallel, so as to limit the flow of the auxiliary fluid from the second chamber to the first chamber.

Hydraulic valves for dampening pressure spikes and associated methods are disclosed herein. In one embodiment, a hydraulic valve for dampening pressure spikes includes: a spool configured to move axially inside the hydraulic valve; and a sleeve configured to at least partially house the spool. A location of the spool with respect to the sleeve may determine a flow of a working fluid through the hydraulic valve. A viscous damper is at least partially housed inside an opening in the spool, and a viscous friction between the viscous damper and the opening in the spool slows a motion of the spool.