Described are fluid pumping and fluid handling systems, which may be suitable for use in medical devices, such as artificial or extracorporeal blood pumping systems. The systems can include a dual housing configuration for pneumatic actuation comprising a main housing containing a pump cassette comprising a pneumatically actuated pump and pneumatically actuated valves. The pump can include a pump actuation chamber and pump pneumatic port, and the valves can each include a valve actuation chamber and valve pneumatic port. Connecting tubes can be used to fluidly connect the pump actuation ports and valve actuation ports to a tube-support housing having a first side receiving one end of each connecting tube and a second side providing a pneumatic interface arranged to connect to an array of pneumatic receptacles on a base unit of the system to facilitate easy, compact and accurate pneumatic interconnection between the pump cassette and the base unit.

Described are fluid pumping and fluid handling systems, which may be suitable for use in medical devices, such as artificial or extracorporeal blood pumping systems. The systems can include a dual housing configuration for pneumatic actuation comprising a main housing containing a pump cassette comprising a pneumatically actuated pump and pneumatically actuated valves. The pump can include a pump actuation chamber and pump pneumatic port, and the valves can each include a valve actuation chamber and valve pneumatic port. Connecting tubes can be used to fluidly connect the pump actuation ports and valve actuation ports to a tube-support housing having a first side receiving one end of each connecting tube and a second side providing a pneumatic interface arranged to connect to an array of pneumatic receptacles on a base unit of the system to facilitate easy, compact and accurate pneumatic interconnection between the pump cassette and the base unit.

Methods and systems of admixing hydrocarbon liquids from a plurality of tanks into a single pipeline thereof. The system may include two or more tanks positioned at a tank farm each containing a hydrocarbon liquid therein. The system may include two or more first main pipes, each connected to one of the tanks. The system may include two or more main valves, each connected to one of the first main pipes. The system may include two or more second main pipes each connected to a corresponding main valve. The system may include two or more mixing jumpers, each connected to a corresponding first main pipe, each mixing jumper to, when a corresponding main valve is closed, control hydrocarbon liquid. The system may include a mixing pipe, connected to the second main pipes and the mixing jumpers, configured to transport hydrocarbon liquid from one or more of the tanks.

A microfluidic device includes an input source characterized by a source pressure, an input channel in fluid communication with the input source, and an output channel. The microfluidic device also includes a normally closed valve having a closed state and an open state. The normally closed valve is disposed between the input channel and the output channel. The microfluidic device further includes one or more release chambers coupled to a pressure source. Activation of the pressure source deforms the one or more release chambers, placing the normally closed valve in the open state.

A microfluidic device includes an input source characterized by a source pressure, an input channel in fluid communication with the input source, and an output channel. The microfluidic device also includes a normally closed valve having a closed state and an open state. The normally closed valve is disposed between the input channel and the output channel. The microfluidic device further includes one or more release chambers coupled to a pressure source. Activation of the pressure source deforms the one or more release chambers, placing the normally closed valve in the open state.

Systems for monitoring fluid flow in an extracorporeal blood circuit are described. The blood circuit of such systems can include plod pump having a pumping chamber of the blood pump separated from a control chamber of the blood pump by a flexible diaphragm. The control chamber can be configured to transmit positive or negative pressure to operate the diaphragm. The system can include a pressure sensor configured to measure pressure in the control chamber of the blood pump, and a controller configured to receive information from the pressure sensor and to control the delivery of pressure to the control chamber of the blood pump. The controller can also be configured to cause the application of a time-varying pressure waveform on the blood pump diaphragm during a fill-stroke of the blood pump, and to monitor a pressure variation in the control chamber measured by the pressure sensor. When so configured, such controller can transmit a value representing a magnitude of the measured pressure variation to a display associated with the extracorporeal blood circuit.

Systems for monitoring fluid flow in an extracorporeal blood circuit are described. The blood circuit of such systems can include plod pump having a pumping chamber of the blood pump separated from a control chamber of the blood pump by a flexible diaphragm. The control chamber can be configured to transmit positive or negative pressure to operate the diaphragm. The system can include a pressure sensor configured to measure pressure in the control chamber of the blood pump, and a controller configured to receive information from the pressure sensor and to control the delivery of pressure to the control chamber of the blood pump. The controller can also be configured to cause the application of a time-varying pressure waveform on the blood pump diaphragm during a fill-stroke of the blood pump, and to monitor a pressure variation in the control chamber measured by the pressure sensor. When so configured, such controller can transmit a value representing a magnitude of the measured pressure variation to a display associated with the extracorporeal blood circuit.

Methods and systems of operating a pump at an efficiency point during an in-line blending operation. In an embodiment, such a method may include transporting a fluid from a tank to a pump through a first pipe. The method may include discharging, via the pump, the fluid at a specified flow rate through a second pipe. The method may include measuring a flow rate of the first portion of the fluid flowing from the main control valve through the mixing pipe. The method may include measuring a flow rate of the second portion of the fluid flowing through the spillback loop. The method may include determining a current pump efficiency point and operating the pump within a range of percentages of the best efficiency point.

Methods and systems of operating a pump at an efficiency point during an in-line blending operation. In an embodiment, such a method may include transporting a fluid from a tank to a pump through a first pipe. The method may include discharging, via the pump, the fluid at a specified flow rate through a second pipe. The method may include measuring a flow rate of the first portion of the fluid flowing from the main control valve through the mixing pipe. The method may include measuring a flow rate of the second portion of the fluid flowing through the spillback loop. The method may include determining a current pump efficiency point and operating the pump within a range of percentages of the best efficiency point.

Embodiments include systems and methods of in-line mixing of hydrocarbon liquids from a plurality of tanks into a single pipeline. According to an embodiment, a method of admixing hydrocarbon liquids from a plurality of tanks into a single pipeline to provide in-line mixing thereof includes determining a ratio of a second fluid flow to a first fluid flow based on signals received from a tank flow meter in fluid communication with the second fluid flow and a booster flow meter in fluid communication with a blended fluid flow. The blended fluid flow includes a blended flow of the first fluid flow and the second fluid flow. The method further includes comparing the determined ratio to a pre-selected set point ratio thereby to determine a modified flow of the second fluid flow to drive the ratio toward the pre-selected set point ratio. The method further includes controlling a variable speed drive connected to a pump thereby to control the second fluid flow through the pump based on the determined modified flow, the pump being in fluid communication with the second fluid flow.