The present invention provides improved methods for characterizing kinetics and thermodynamics of solutions containing macromolecules over a range of concentrations, temperatures, pH, and added excipients in order to improve their long term stability.

The present invention provides improved methods for characterizing kinetics and thermodynamics of solutions containing macromolecules over a range of concentrations, temperatures, pH, and added excipients in order to improve their long term stability.

Various examples are provided related to scanning tunneling thermometers and scanning tunneling microscopy (STM) techniques. In one example, a method includes simultaneously measuring conductance and thermopower of a nanostructure by toggling between: applying a time modulated voltage to a nanostructure disposed on an interconnect structure, the time modulated voltage applied at a probe tip positioned over the nanostructure, while measuring a resulting current at a contact of the interconnect structure; and applying a time modulated temperature signal to the nanostructure at the probe tip, while measuring current through a calibrated thermoresistor in series with the probe tip. In another example, a device includes an interconnect structure with connections to a first reservoir and a second reservoir; and a scanning tunneling probe in contact with a probe reservoir. Electrical measurements are simultaneously obtained for temperature and voltage applied to a nanostructure between the reservoirs.

Various examples are provided related to scanning tunneling thermometers and scanning tunneling microscopy (STM) techniques. In one example, a method includes simultaneously measuring conductance and thermopower of a nanostructure by toggling between: applying a time modulated voltage to a nanostructure disposed on an interconnect structure, the time modulated voltage applied at a probe tip positioned over the nanostructure, while measuring a resulting current at a contact of the interconnect structure; and applying a time modulated temperature signal to the nanostructure at the probe tip, while measuring current through a calibrated thermoresistor in series with the probe tip. In another example, a device includes an interconnect structure with connections to a first reservoir and a second reservoir; and a scanning tunneling probe in contact with a probe reservoir. Electrical measurements are simultaneously obtained for temperature and voltage applied to a nanostructure between the reservoirs.

A method of monitoring the pressure of a tire of an aircraft is disclosed including taking two or more pressure readings from the tire at different times; calculating an estimated deflation rate based on the pressure readings; and calculating a time for the tire to deflate to a reference pressure level based on the estimated deflation rate. Two or more temperature readings are each associated with one of the pressure readings, and the estimated deflation rate is calculated by normalising each pressure reading based on its associated temperature reading and a common reference temperature to obtain a temperature-normalised pressure reading, and calculating the estimated deflation rate based on the temperature-normalised pressure readings. The estimated deflation rate is compared with a threshold, and a warning provided if the estimated deflation rate exceeds the threshold.

A method of monitoring the pressure of a tire of an aircraft is disclosed including taking two or more pressure readings from the tire at different times; calculating an estimated deflation rate based on the pressure readings; and calculating a time for the tire to deflate to a reference pressure level based on the estimated deflation rate. Two or more temperature readings are each associated with one of the pressure readings, and the estimated deflation rate is calculated by normalising each pressure reading based on its associated temperature reading and a common reference temperature to obtain a temperature-normalised pressure reading, and calculating the estimated deflation rate based on the temperature-normalised pressure readings. The estimated deflation rate is compared with a threshold, and a warning provided if the estimated deflation rate exceeds the threshold.

A system may include a plurality of sensors, a measurement circuit communicatively coupled to the plurality of sensors and configured to measure one or more physical quantities associated with the plurality of sensors, and a predictive optimization subsystem configured to detect an event associated with a first sensor of the plurality of sensors and responsive to the event, execute a predictive action with respect to one or more of the other sensors of the plurality of sensors.

A system may include a plurality of sensors, a measurement circuit communicatively coupled to the plurality of sensors and configured to measure one or more physical quantities associated with the plurality of sensors, and a predictive optimization subsystem configured to detect an event associated with a first sensor of the plurality of sensors and responsive to the event, execute a predictive action with respect to one or more of the other sensors of the plurality of sensors.

Provided is a temperature derivation method for deriving an oil film temperature of a lubricant in a device, the temperature derivation method including a measurement step of measuring a dielectric constant of the lubricant by applying an alternating voltage while changing a frequency to an electric circuit configured by the device, a derivation step of 5 applying the dielectric constant measured in the measurement step to a theoretical formula to derive a relaxation time of the lubricant, and a calculation step of calculating the oil film temperature by using the relaxation time.

Provided is a temperature derivation method for deriving an oil film temperature of a lubricant in a device, the temperature derivation method including a measurement step of measuring a dielectric constant of the lubricant by applying an alternating voltage while changing a frequency to an electric circuit configured by the device, a derivation step of 5 applying the dielectric constant measured in the measurement step to a theoretical formula to derive a relaxation time of the lubricant, and a calculation step of calculating the oil film temperature by using the relaxation time.