An apparatus adapted to examine a paper web includes a rotatable first bobbin, a rotatable second bobbin, and a first testing device. The first bobbin has a paper we wound thereabout that has transverse bands spaced apart along a length thereof. The second bobbin is arranged to receive the paper web from the first bobbin with a paper web path defined between the first and second bobbins. The first testing device is disposed along the paper web path and is arranged to nondestructively measure a diffusivity of one of the transverse bands of the paper web.

The invention relates to a method for cleaning dissolution vessels and for the subsequent dosing of a dissolution media, and to mobile modular cleaning and dosing equipment for the implementation of said method. According to said method, injected water steam is used for the cleaning and is subsequently aspirated, together with the residues of the dissolution, and the vessel is then refilled with the desired quantity of a new dissolution media. The mobile modular cleaning and dosing equipment allows the cleaning and dosing to be carried out in situ without having to remove the dissolution vessels from the equipment or site where the dissolution tests are carried out, using self-sufficient modular equipment, and a novel steam supply line is used for the cleaning, which sprays the steam against the bottom of the vessel and the inner side walls.

The invention relates to a method for cleaning dissolution vessels and for the subsequent dosing of a dissolution media, and to mobile modular cleaning and dosing equipment for the implementation of said method. According to said method, injected water steam is used for the cleaning and is subsequently aspirated, together with the residues of the dissolution, and the vessel is then refilled with the desired quantity of a new dissolution media. The mobile modular cleaning and dosing equipment allows the cleaning and dosing to be carried out in situ without having to remove the dissolution vessels from the equipment or site where the dissolution tests are carried out, using self-sufficient modular equipment, and a novel steam supply line is used for the cleaning, which sprays the steam against the bottom of the vessel and the inner side walls.

Systems and methods of forming and analyzing a dissolvable article are provided herein. In an embodiment, a method of forming a dissolvable article with excellent dissolution performance includes heating a dissolvable composition that includes a water-soluble block copolymer at heating conditions that are sufficient to render the copolymer flowable and to form a hot melt composition. The water-soluble block copolymer is solid at ambient conditions. The method further includes solidifying the dissolvable composition to form the dissolvable article. A surface of the dissolvable article is analyzed for surface texture using a three-dimensional imaging device to produce a data set that is representative of the surface texture. If the data set fails to at least equal a predetermined threshold value, the method further includes reformulating the dissolvable composition to form a reformulated dissolvable composition.

A gas sensor includes an electrically conductive membrane that bends with an applied surface stress, a fixing member disposed outside the membrane, a coupling portion that couples together the membrane and the fixing member, a flexible resistor whose resistance value changes in accordance with a deflection that occurs in the coupling portion, a conductive support substrate connected to the fixing member and disposed with a gap between the membrane and the coupling portion, a receptor which is formed on an area including the center of a surface on one side of the membrane which is opposite to the other side facing the support substrate, and deforms in accordance with a substance adsorbed, a first terminal capable of applying a first potential to the membrane, a second terminal capable of applying a second potential to the support substrate, and an insulating portion electrically insulating the fixing member from the support substrate.

When the mesh is placed under the bottom of a blade and over the bottom of a vessel in the dissolution test assembly equipped with either a vessel specified in the dissolution test method of the Japanese Pharmacopoeia, the United States Pharmacopoeia or the European Pharmacopoeia or a vessel used for the dissolution test, and a paddle formed from a blade and a shaft, and the suspensions and the solid dosage forms are added to or placed at the said mesh, a drug dissolves from the said dosage forms and the dissolution ratio variation between the said multiple same dosage forms can be small.

When the mesh is placed under the bottom of a blade and over the bottom of a vessel in the dissolution test assembly equipped with either a vessel specified in the dissolution test method of the Japanese Pharmacopoeia, the United States Pharmacopoeia or the European Pharmacopoeia or a vessel used for the dissolution test, and a paddle formed from a blade and a shaft, and the suspensions and the solid dosage forms are added to or placed at the said mesh, a drug dissolves from the said dosage forms and the dissolution ratio variation between the said multiple same dosage forms can be small.

A method of determining properties of a fluid having an oil phase, a water phase, and an emulsion phase between the oil phase and water phase includes emitting an electromagnetic wave into the fluid, measuring an amplitude of a reflection of the electromagnetic wave off an interface between the oil phase in order to determine a height of a coalescing portion of the oil/emulsion interface. A height of a creaming portion of the emulsion/water interface is then determined using the coalescing portion height, total fluid height and water-in-liquid ratio. A thickness of the emulsion phase is determined based on the difference between coalescing and creaming portion height.

A method of determining properties of a fluid having an oil phase, a water phase, and an emulsion phase between the oil phase and water phase includes emitting an electromagnetic wave into the fluid, measuring an amplitude of a reflection of the electromagnetic wave off an interface between the oil phase in order to determine a height of a coalescing portion of the oil/emulsion interface. A height of a creaming portion of the emulsion/water interface is then determined using the coalescing portion height, total fluid height and water-in-liquid ratio. A thickness of the emulsion phase is determined based on the difference between coalescing and creaming portion height.

A TDR matrix suction sensor measures the matrix suction exhibited by a porous medium surrounding the sensor. The sensor is constructed from a TDR matrix suction sensor probe, which includes two or more elongated conductors and a jacket that encases the conductors. The jacket is made of a hydrophilic, non-conductive, porous (HN-CP) material. In operation, a pulse delay time is computed for an electrical pulse injected into the proximal end of the conductors and reflected when reaching their distal ends. The pulse delay time and a delay-to-matrix suction profile of the HN-CP jacket material are used to compute the matrix suction exhibited by the probe jackets. An indicator of the current value of the matrix suction exhibited by the porous medium is then established based on the matrix suction computed for the HN-CP jackets.