Provided is a chip that does not require high-accuracy discharge amount control for a liquid delivery pump and can suppress the entrainment of air bubbles. A chip 1 for test or analysis is provided with a flow path 4 through which a fluid is delivered, the chip 1 including: a first flow path 5 through which a first fluid is delivered; a second flow path 6 through which a second fluid is delivered; a merging portion 8 configured to be provided on a downstream end portion 5a side of the first flow path 5 and merge the first fluid and the second fluid; a first connection flow path 9 configured to connect the first flow path 5 and the second flow path 6 at the merging portion 8 and have a liquid delivery resistance higher than a liquid delivery resistance of the first flow path 5; a degassing flow path 13 configured to be connected to the second flow path 6 on a downstream side of the first connection flow path 9; a third flow path 7 configured to be provided on a downstream side of the merging portion 8; and a second connection flow path 10 configured to connect the first flow path 5 and the third flow path 7 and have a liquid delivery resistance higher than the liquid delivery resistance of the first flow path 5.

A microfluidic system includes a chip holder that holds a microchip including a plurality of reservoirs, a chip cover, a sealing member; a dispensing probe, a suction mechanism, a first storage where a first cleaning solution is stored, a second storage where a second cleaning solution is stored, a pump, a channel switch, and a controller. The channel switch is configured to switch between a channel through which the first cleaning solution is suctioned from the first storage and a channel through which the second cleaning solution is suctioned from the second storage. The controller controls operations of the channel switch and the pump.

In an aspect, the present invention provides a structure, a structure-manufacturing method, a cell-sorting method, or the like. In an aspect, a structure (1) of the present invention is a structure including a first substrate (10) and a second substrate (20) disposed to face one side of the first substrate (10), in which the first substrate (10) has a plurality of depressions (11) which are open to the other side of the first substrate and each of which has a size that enables each of the depressions to capture one unit of a cell, at least some of the depressions (11) have communication holes (12) which communicate with one side and the other side of the first substrate and each of which has a size that enables secretions secreted from the cell to move through the communication holes, the second substrate (20) can include accumulation portions (13) in which the secretions moving through the communication holes (12) are accumulated, and the accumulation portions (13) can correspond to the depressions (11).

In an aspect, the present invention provides a structure, a structure-manufacturing method, a cell-sorting method, or the like. In an aspect, a structure (1) of the present invention is a structure including a first substrate (10) and a second substrate (20) disposed to face one side of the first substrate (10), in which the first substrate (10) has a plurality of depressions (11) which are open to the other side of the first substrate and each of which has a size that enables each of the depressions to capture one unit of a cell, at least some of the depressions (11) have communication holes (12) which communicate with one side and the other side of the first substrate and each of which has a size that enables secretions secreted from the cell to move through the communication holes, the second substrate (20) can include accumulation portions (13) in which the secretions moving through the communication holes (12) are accumulated, and the accumulation portions (13) can correspond to the depressions (11).

Provided is a microchannel device, which has high hydrophobicity, high mechanical strength, and safety and also has high solvent resistance, and thus has wider applicability. The microchannel device includes a porous substrate having formed therein channel walls each containing a cyclic olefin copolymer that is a copolymer of an alkene and a cyclic olefin.

In a container including two accommodation parts each accommodating liquid, mixing of the liquids in a case of moving magnetic particles in the liquid accommodated in one accommodation part to the other accommodation part is suppressed. Provided is a container includes a first accommodation part which accommodates a first liquid containing magnetic particles, a second accommodation part which accommodates separated magnetic particles separated from the first liquid, and a second liquid, and a flow passage which allows the first accommodation part and the second accommodation part to communicate with each other, and through which the separated magnetic particles pass, in which the flow passage has a first staircase part including two or more steps from an inner bottom surface of the first accommodation part on a first accommodation part side.

In a method for comparative analysis, the expression levels of the target miRNAs in each body fluid sample are corrected using the expression level(s) of a correcting endogenous miRNA(s) that is/are simultaneously measured with the expression levels of the target miRNAs in the sample. As the correcting endogenous miRNA(s), one or more miRNAs selected from specific 10 kinds of correcting endogenous miRNAs is/are used. Comparative analysis of target miRNAs among body fluid samples can be carried out more accurately than by conventional techniques.

In a method for comparative analysis, the expression levels of the target miRNAs in each body fluid sample are corrected using the expression level(s) of a correcting endogenous miRNA(s) that is/are simultaneously measured with the expression levels of the target miRNAs in the sample. As the correcting endogenous miRNA(s), one or more miRNAs selected from specific 10 kinds of correcting endogenous miRNAs is/are used. Comparative analysis of target miRNAs among body fluid samples can be carried out more accurately than by conventional techniques.

There are provided a detection sensor, a detection sensor kit, a sensor device, a method for producing a detection sensor and a detection method which enable measurement by a simple operation. A detection sensor includes a detecting element, a first member and a second member. The detecting element detects a detection object contained in a sample. The first member includes a first channel portion, and the first channel portion includes a first storage section which stores a reagent which is fed to the detecting element. The second member is movable relative to the first member and includes a second channel portion. In the detection sensor, the first member and the second member are joined with each other and form a joined channel in which the first channel portion and the second channel portion communicate with each other.

To provide a technique capable of stably forming droplets.

There is provided a microparticle sorting device and the like including: an imaging element configured to acquire an image of fluid and a droplet at a position where liquid discharged from an orifice that generates a stream of the fluid is converted into a droplet; and a processing unit configured to determine a harmonic superposition amplitude ratio, a harmonic phase difference, and a superimposed wave voltage on the basis of states of a satellite droplet and a break-off point in the image.