It is intended to provide a kit or device for the detection of liver cancer and a method for detecting liver cancer. The present invention relates to a kit or device for the detection of liver cancer, comprising a nucleic acid capable of specifically binding to miRNA in a sample of a subject, and a method for detecting liver cancer, comprising measuring the miRNA in vitro.

It is intended to provide a kit or device for the detection of liver cancer and a method for detecting liver cancer. The present invention relates to a kit or device for the detection of liver cancer, comprising a nucleic acid capable of specifically binding to miRNA in a sample of a subject, and a method for detecting liver cancer, comprising measuring the miRNA in vitro.

A reaction container includes a transparent base including a resin material and having recessed portions formed in one or more regions of the transparent base such that the recessed portions are recessed from a surface of the transparent base, and a cover member including a thermoplastic resin material and positioned on the transparent base such that the cover member forms a flow path including a gap extending over the recessed portions between the cover member and the surface of the transparent base and has a spacer portion welded by laser irradiation to the transparent base outside the one or more regions of the transparent base. The cover member absorbs infrared light and transmits light having a wavelength within a range of visible light such that the cover member has light transmittance in the range of from 480 nm to 570 nm.

A reaction container includes a transparent base including a resin material and having recessed portions formed in one or more regions of the transparent base such that the recessed portions are recessed from a surface of the transparent base, and a cover member including a thermoplastic resin material and positioned on the transparent base such that the cover member forms a flow path including a gap extending over the recessed portions between the cover member and the surface of the transparent base and has a spacer portion welded by laser irradiation to the transparent base outside the one or more regions of the transparent base. The cover member absorbs infrared light and transmits light having a wavelength within a range of visible light such that the cover member has light transmittance in the range of from 480 nm to 570 nm.

Provided is a separating apparatus including separating unit configured to apply external force to a fluid sample containing two or more components immiscible with each other and having different specific gravities to separate the fluid sample into separation target and non-separation target, and a transfer mechanism configured to apply a pressure to the separation target separated by the separating unit to transfer the separation target.

The objective of the present invention is to provide a fluid handling device capable of easily isolating droplets. This objective is achieved by means of a fluid handling device which includes a first flow passage through the interior of which, when a fluid containing a droplet is delivered, the droplet can move, a first chamber which captures the droplet moving through the first flow passage, a second chamber into which the droplet captured by the first chamber can move, and a second flow passage providing communication between the first chamber and the second chamber, wherein the second flow passage is capable of selectively allowing the droplet to pass, or restricting passage of the droplet.

A chip includes a first chamber that stores a fluid, a second chamber that stores a mixing target which is to be mixed with the fluid, a flow path that allows a communication between the first chamber and the second chamber, and a valve that is provided in the flow path and capable of changing the flow path by change in shape by heating.

This invention is intended to accurately determine the presence or absence of a plurality of types of gene mutations in CALR or JAK2 among gene mutations related to myeloproliferative neoplasms. A CALR mutation probe reacts with any of the type 1, type 3, type 4, or the type 5 mutation related to myeloproliferative neoplasms and has a mismatch resulting from artificial deletion. Probes for JAK2 mutation encompass a V617F mutation probe and an exon 12 mutation probe.

An improved device and system for facilitating polymerase chain reaction including a light source, detector, waveguide, and filters that occupy minimal space and facilitate detection of stationary samples, reduced sample read time, and simultaneous reading of multiple light wavelengths.

A reaction container including a transparent base having a first surface having at least one region where recessed portions are formed and recessed from the first surface, and a cover member positioned such that the cover member forms a gap from the first surface inside the region and is welded to the transparent base outside the region. The cover member absorbs infrared light and transmits light having a wavelength within a range of visible light.