A method is provided for determining, the presence and concentration of an analyte by contacting the sample with a solution comprising: magnetic beads, a capture probe capable of binding the analyte, a reporter probe and cellulose, whereby, if the analyte is present, an MB-analyte-reporter-cellulase sandwich is formed; and then contacting the solution comprising the sandwich with an electrode covered with an electrically insulating layer comprising or consisting of cellulose and/or a cellulose derivative, wherein the MB-analyte-reporter-cellulase sandwich leads to degradation of the insulating layer thereby causing a measurable change in electrical properties at the electrode surface, wherein the change in electrical properties is a function of the amount of analyte in the sample. Devices and biosensor applying the method are also provided.

The invention relates to methods for conducting binding assays in an assay device that includes one or more storage and use zone. The storage zones of the assay device are configured to house one or more reagents used in an assay conducted in the use zone of the device.

The invention includes methods and kits for the detection of a virus that may be in a sample. In embodiments, the invention includes a method of detecting a virus in a sample by forming a reaction mixture exposing an aliquot of the sample purportedly containing a virus to an immobilized receptor. A soluble receptor including a detectable label is added to the reaction mixture. A washing step washes the immobilized receptor, and the detectable label is detected.

A system and method for sorting and printing of cancer cells in general and more specifically a system and a method for enriching cancer cells in a sample using magneto-phoresis and cytology rotor in cell centrifuge using cytospin method. The present invention comprises a technological advantage over known systems and methods by use of a dynamic system wherein a fluid flow comprising cells flow across a magnetic field to separate cells based on absence or presence of paramagnetic nano particles attached to them.

A specimen measurement device which detects a measurement object material according to the present embodiment, includes: a magnetic field applicator configured to apply a magnetic field to a measurement cartridge including a substrate, a first substance fixed on the substrate and specifically reacting with the measurement object material, a magnetic particle, and a substance fixed on the magnetic particle and specifically acting with the measurement object material; a detector configured to detect light passing through the substrate; and a controller configured to control the magnetic field applicator to perform a first operation to apply a first magnetic field in a direction to move the magnetic particle away from the substrate when a specimen solution containing the measurement object material is introduced into the measurement cartridge, and then perform a second operation to apply a second magnetic field in a direction to move the magnetic particle toward the substrate.

Methods for preventing aggregation of detection particles in a test for detecting a multi-epitope target analyte comprising two or more similar or identical epitopes in a sample and/or for determining the concentration of the multi-epitope target analyte in a sample by applying a first capture entity which can specifically bind to at least one epitope on the multi-epitope analyte and block the at least one epitope from binding to a detection particle. The detection of the multi-epitope target analyte may further include the use of a second capture entity, which can specifically bind to the same or a similar epitope of the multi-epitope target analyte as the first capture entity. The multi-epitope target may be detected through the use of a system comprising a sensor surface and the use of a first capture entity to block the at least one epitope from binding to a detection particle.

The purpose of the present invention is to provide a simple measurement tool which can rapidly measure various chemical substances contained in environments or from inside a living body by a simple or inexpensive means/method. The present inventions relate to, for example, a simple measurement tool for test substances comprising: at least two reaction regions, each composed of a water-based liquid, the reaction regions being independent of each other; boundary region(s) composed of a gel-type substance that is not or hardly soluble in the water-based liquid; a container holding the reaction regions and the boundary region(s); and magnetic particles carrying a reactive substance immobilized on a surface thereof, in which: the reaction regions are separated from each other via the boundary region(s); and by using external magnetic field-applying means, the magnetic particles can be substantially exclusively transferred from one reaction region to another reaction region through the boundary region separating these reaction regions, while independence of the respective reaction regions and the respective boundary regions and a function of the magnetic particles being maintained.

The invention relates to methods for conducting binding assays in an assay device that includes one or more storage and use zone. The storage zones of the assay device are configured to house one or more reagents used in an assay conducted in the use zone of the device.

The application relates to a method for detecting a target in a sample suspected of containing the target. The method comprises contacting the sample and a first binding molecule attached to a magnetic particle with a second binding molecule attached to a solid support. The first binding molecule is capable of binding to the second binding molecule, and the target is capable of interfering with this binding. Magnetic force is applied to bring the magnetic particle into close proximity with the solid support. The number of magnetic particles bound to the solid support is detected.

The present invention relates to a magnetic particle dispersion, and the magnetic particle dispersion includes a magnetic particle, an isothiazoline compound, and an aqueous medium.