A diagnosis support device includes a processor and a memory connected to or built in the processor. The processor is configured to perform non-linear registration processing of a target image which is a medical image to be analyzed and at least one representative image generated from a plurality of medical images, input at least one of transformation amount information of the target image obtained by the non-linear registration processing or a feature amount derived from the transformation amount information to a disease opinion derivation model, and output a disease opinion from the disease opinion derivation model.

A system for collecting and retaining a sample from exhaled breath of a subject for analysis can include a two part housing, a two part trap section, and optionally a boat fitment. Disclosed is a portable fluid sampling device comprising: a housing including a first portion removably attachable to a second portion, the first and second portions being configured to combine to form a chamber therein, the chamber being configured to at least temporarily contain or hold a biological sample therein, at least one of the first portion and the second portion including an inlet, the other of the first portion and the second portion including an outlet, wherein the device further comprises at least one of the following: a) one of the first portion and the second portion including an end having a projection, the other of the first portion and the second portion including an end having a groove, the groove being configured to receive at least a portion of the projection therein; or b) tamper evident means for indicating that the first portion of the housing has previously been separated from the second portion of the housing.

An absorbent article is worn to receive discharged urine of the wearer. The article includes a liquid-permeable top sheet, an intermediate liquid-absorbent layer, a bottom sheet including at least one indicator and a liquid-impermeable backing layer. Each of the at least one externally visible indicator is coated or impregnated with at least one chemical reagent facing the liquid-absorbent layer. Each of the at least one chemical reagent is configured to undergo a change in color or shade from a plurality of different possible color or shade changes of the reagent upon contact with the discharged urine. Each color or shade is associated with a corresponding level of an analyzed component or with the presence or absence of the analyzed component and the change in color or shade of the at least one chemical reagent is externally visible on the indicator through the bottom sheet and the backing layer.

An absorbent article is worn to receive discharged urine of the wearer. The article includes a liquid-permeable top sheet, an intermediate liquid-absorbent layer, a bottom sheet including at least one indicator and a liquid-impermeable backing layer. Each of the at least one externally visible indicator is coated or impregnated with at least one chemical reagent facing the liquid-absorbent layer. Each of the at least one chemical reagent is configured to undergo a change in color or shade from a plurality of different possible color or shade changes of the reagent upon contact with the discharged urine. Each color or shade is associated with a corresponding level of an analyzed component or with the presence or absence of the analyzed component and the change in color or shade of the at least one chemical reagent is externally visible on the indicator through the bottom sheet and the backing layer.

A portable handheld sampling device for collecting aerosol particles in a stream of exhaled breath provided with an inlet and an outlet, wherein the sampling device further comprises a housing and a collecting device holder removably arranged at least partially inside the housing, wherein the housing and the collecting device holder are arranged to guide the stream of exhaled breath through the device from the inlet to the outlet, wherein said collecting device holder comprises at least two cylindrical conduits arranged in parallel, each defining a flow path in fluid connection with the inlet, wherein a cylindrical collecting device is arranged in each conduit, the collecting device being adapted to collect the aerosol particles in the exhaled breath. A method for collecting aerosol particles in exhaled breath of a user using a portable handheld sampling device by means of a reopening breathing maneuver.

A portable handheld sampling device for collecting aerosol particles in a stream of exhaled breath provided with an inlet and an outlet, wherein the sampling device further comprises a housing and a collecting device holder removably arranged at least partially inside the housing, wherein the housing and the collecting device holder are arranged to guide the stream of exhaled breath through the device from the inlet to the outlet, wherein said collecting device holder comprises at least two cylindrical conduits arranged in parallel, each defining a flow path in fluid connection with the inlet, wherein a cylindrical collecting device is arranged in each conduit, the collecting device being adapted to collect the aerosol particles in the exhaled breath. A method for collecting aerosol particles in exhaled breath of a user using a portable handheld sampling device by means of a reopening breathing maneuver.

A medical needle arrangement (100, 1000, 1400) is disclosed. The needle arrangement (100, 1000, 1400) comprises: a needle sheath (104, 002, 1402), and a needle (202, 1102, 1406) comprising: an elongated portion and a sealing member (204, 1003, 1403) being arranged to a front end of the elongated portion. The needle arrangement is adapted to bet set in: a closed position, in which the sealing member (204, 1003, 1403) is arranged to abut at least a portion of a front end surface of the needle sheath (104, 1002, 1402) thereby restricting intrusion of foreign matter in an area between the needle sheath and the needle, and an open position, in which a gap (1204, 1506) is formed between the sealing member (204, 1003, 1403) and the front end surface of the needle sheath (104, 1002, 1402). Embodiments include needle arrangement for injection, for aspiration, and for biopsy purposes.

Example aspects of a volatile organic compound detection device, a wearable health monitoring device, and a method of monitoring a user's health are disclosed. The volatile organic compound detection device can comprise a collector comprising a collector material configured to collect volatile organic compounds given off from a user's skin; a separator comprising a gas chromatography column configured to separate mixtures of the volatile organic compounds into their constituent chemicals; and an identifier comprising a detector and a processor, the detector configured to transduce the constituent chemicals into a signal, the processor configured to process the signal to identify specific volatile organic compounds indicative of a health condition.

Example aspects of a volatile organic compound detection device, a wearable health monitoring device, and a method of monitoring a user's health are disclosed. The volatile organic compound detection device can comprise a collector comprising a collector material configured to collect volatile organic compounds given off from a user's skin; a separator comprising a gas chromatography column configured to separate mixtures of the volatile organic compounds into their constituent chemicals; and an identifier comprising a detector and a processor, the detector configured to transduce the constituent chemicals into a signal, the processor configured to process the signal to identify specific volatile organic compounds indicative of a health condition.

A wearable biofluid volume and composition system includes a microfluidic flexible fluid capture substrate having a microfluidic channel configured as a sweat collection channel and is configured to be worn on a human body and to collect and analyze biofluid. The microfluidic flexible fluid capture substrate further has a plurality of conductive traces and electrodes. An electronic module is attached to the microfluidic flexible fluid capture substrate and is configured to measure and analyze data from the biofluid collected by the microfluidic flexible fluid capture substrate and to transmit the analyzed data to a smart device.