The disclosure relates to a computer-implemented method, system, and storage medium for collaborative development of a reagent for detection of the target nucleic acid. According to the disclosure, the method, system, and storage medium automatically match the developer and technology provider suitable for the characteristics of collaborative development in response to a request for collaborative development, thereby increasing the efficiency of collaborative development.

The disclosure relates to a computer-implemented method, system, and storage medium for collaborative development of a reagent for detection of the target nucleic acid. According to the disclosure, the method, system, and storage medium automatically match the developer and technology provider suitable for the characteristics of collaborative development in response to a request for collaborative development, thereby increasing the efficiency of collaborative development.

The disclosure provides methods to assemble genomes of eukaryotic or prokaryotic organisms. The disclosure further provides methods for haplotype phasing and meta-genomics assemblies.

The disclosure provides methods to assemble genomes of eukaryotic or prokaryotic organisms. The disclosure further provides methods for haplotype phasing and meta-genomics assemblies.

The invention relates to a sequence analysis method or sequence generation method for analysing or generating sequences of encoding elements of a particular DNA, RNA, or macromolecule sequence. The invention also relates to a manual, automated or computer implemented method of recognizing, analysing, probing, testing, processing, sequencing and sensing DNA or other macromolecular sequences.

The invention relates to a sequence analysis method or sequence generation method for analysing or generating sequences of encoding elements of a particular DNA, RNA, or macromolecule sequence. The invention also relates to a manual, automated or computer implemented method of recognizing, analysing, probing, testing, processing, sequencing and sensing DNA or other macromolecular sequences.

In one aspect, a method includes generating a design space for a peptide for an application. The generating includes identifying sequences for the peptide, and updating the sequences by determining, for each of the sequences, a respective set of activities pertaining to the application. The updating produces updated sequences each having updated respective activities. The method includes generating, based on the updated sequences, a solution space within the design space. The solution space includes a target subset of the updated sequences. The method includes performing, using a machine learning model to process the solution space, trials to identify a candidate drug compound that represents a sequence having a level of activity that exceeds a threshold level, and transmitting information describing the candidate drug compound to a computing device.

The present invention relates to a method and system for dynamically analyzing, determining, predicting and displaying ranked suitable heterologous biosynthesis pathways for a specified host. The present invention addresses the problem of finding suitable pathways for the endogenous metabolism of a host organism because the efficacy of heterologous biosynthesis is affected by competing endogenous pathways. The present invention is called MRE (Metabolic Route Explorer), and it was conceived and developed to systematically and dynamically search for, determine, analyze, and display promising heterologous pathways while considering competing endogenous reactions in a given host organism.

Methods and systems are provided for determining a variant of interest by analyzing sizes and sequences of cfDNA fragments obtained from a test sample. The methods and systems provided herein implement processes that synergistically combine size and sequence information, thereby improving specificity and sensitivity of assays over conventional methods.

A method for designing a protein capable of binding in an RNA base selective manner or RNA base sequence specific manner is provided. The protein of the present invention is a protein containing one or more of PPR motifs (preferably 2 to 14 PPR motifs) each consisting of a polypeptide of 30- to 38-amino acid length represented by the formula 1 (wherein Helix A is a moiety of 12-amino acid length capable of forming an α-helix structure, and is represented by the formula 2, wherein, in the formula 2, A.sub.1 to A.sub.12 independently represent an amino acid; X does not exist, or is a moiety of 1- to 9-amino acid length; Helix B is a moiety of 11- to 13-amino acid length capable of forming an α-helix structure; and L is a moiety of 2- to 7-amino acid length represented by the formula 3, wherein, in the formula 3, the amino acids are numbered “i” (−1), “ii” (−2), and so on from the C-terminus side, provided that L.sub.iii to L.sub.vii may not exist), and combination of three amino acids A.sub.1, A.sub.4 and L.sub.ii, or combination of two amino acids A.sub.4, and L.sub.ii is a combination corresponding to a target RNA base or base sequence.