Patent classifications
G16B45/00
Deciphering Multi-Way Interactions In The Human Genome With Use Of Hypergraphs
A method is presented for analyzing interactions in a human genome. The method includes: receiving a biological sample of a cell from a subject; extracting read data from the biological sample, where the read data includes a set of reads; and constructing, by a computer processor, a hypergraph from the read data, where each node in the hypergraph represents a locus and hyperedges in the hypergraph represent interactions between two or more loci. The hypergraphs may be used for different applications including determining entropy, comparing different biological samples and reporting multi-way contacts in a set of transcription clusters.
Deciphering Multi-Way Interactions In The Human Genome With Use Of Hypergraphs
A method is presented for analyzing interactions in a human genome. The method includes: receiving a biological sample of a cell from a subject; extracting read data from the biological sample, where the read data includes a set of reads; and constructing, by a computer processor, a hypergraph from the read data, where each node in the hypergraph represents a locus and hyperedges in the hypergraph represent interactions between two or more loci. The hypergraphs may be used for different applications including determining entropy, comparing different biological samples and reporting multi-way contacts in a set of transcription clusters.
Ancestry painting
Displaying an indication of ancestral data is disclosed. An indication that a genetic interval corresponds to a reference interval that has a likelihood of having one or more ancestral origins is received. One or more graphic display parameters are determined based at least in part on the indication. An indication of the one or more ancestral origins is visually displayed using the one or more graphic display parameters.
Systems and methods for modeling a protein parameter for understanding protein interactions and generating an energy map
Systems and methods for modeling a three-dimensional protein structure are disclosed. The method includes receiving a primary amino acid sequence of a three-dimensional protein, translating the primary amino acid sequence to a first vector, determining a per-residue conformation index for each amino acid residue in the primary amino acid sequence, determining a vector set for each amino acid residue in the primary amino acid sequence, and using the per-residue interaction vector set to generate a multi-dimensional matrix for the three-dimensional protein structure. The first vector includes a unique numerical descriptor value corresponding to each amino acid residue in the primary amino acid sequence. The vector set includes a plurality per-residue interaction factors corresponding to a plurality of conformation indexes for that amino acid residue.
Systems and methods for modeling a protein parameter for understanding protein interactions and generating an energy map
Systems and methods for modeling a three-dimensional protein structure are disclosed. The method includes receiving a primary amino acid sequence of a three-dimensional protein, translating the primary amino acid sequence to a first vector, determining a per-residue conformation index for each amino acid residue in the primary amino acid sequence, determining a vector set for each amino acid residue in the primary amino acid sequence, and using the per-residue interaction vector set to generate a multi-dimensional matrix for the three-dimensional protein structure. The first vector includes a unique numerical descriptor value corresponding to each amino acid residue in the primary amino acid sequence. The vector set includes a plurality per-residue interaction factors corresponding to a plurality of conformation indexes for that amino acid residue.
Methods and systems of tracking disease carrying arthropods
The present invention comprises the capture and display of arthropod, human and arthropod-based metadata, which is capable of tracking and displaying the metadata, which is time and location-based, in order to show migration paths of arthropods and/or the diseases they have the potential to carry. This real-time view can help predict future arthropod and disease based on various scenarios such as, but not limited to: increased exposure based on the following: a user's geo-location, date and/or time of year, carrier type, etc. These variables can then assist with the education, awareness and potential prevention of disease.
Methods and systems of tracking disease carrying arthropods
The present invention comprises the capture and display of arthropod, human and arthropod-based metadata, which is capable of tracking and displaying the metadata, which is time and location-based, in order to show migration paths of arthropods and/or the diseases they have the potential to carry. This real-time view can help predict future arthropod and disease based on various scenarios such as, but not limited to: increased exposure based on the following: a user's geo-location, date and/or time of year, carrier type, etc. These variables can then assist with the education, awareness and potential prevention of disease.
Testing and representing suspicion of sepsis
Embodiments of the present technology include a method for testing a blood sample for sepsis. The method may include receiving a blood sample from an individual. The method may also include executing an instruction to analyze the blood sample for sepsis. In addition, the method may include measuring values of a set of characteristics in the blood sample. The set of characteristics being determined prior to measuring the values. The method may further include analyzing the values of the set of characteristics to produce a representation of a suspicion of sepsis. In addition, the method may include displaying the representation. Embodiments also include systems for testing blood sample for sepsis.
Testing and representing suspicion of sepsis
Embodiments of the present technology include a method for testing a blood sample for sepsis. The method may include receiving a blood sample from an individual. The method may also include executing an instruction to analyze the blood sample for sepsis. In addition, the method may include measuring values of a set of characteristics in the blood sample. The set of characteristics being determined prior to measuring the values. The method may further include analyzing the values of the set of characteristics to produce a representation of a suspicion of sepsis. In addition, the method may include displaying the representation. Embodiments also include systems for testing blood sample for sepsis.
User interface, system, and method for cohort analysis
A system and method that receive a distance matrix for multiple patients and a patient of interest, assign a radial distance value between the patient of interest and the other patients based on the distance matrix value for each of the multiple patients, generate an angular distance value between the multiple patients based at least in part on a measure of similarity between each patient, and minimize a cost function based at least in part on the angular distance value between each patient and each other patient. Minimizing the cost function may include calculating a patient contribution to the cost function for a plurality of angular distance values and selecting the angular distance value with the smallest patient contribution. The processor also may be configured to generate and display a radar plot based on the assigned radial distance value and generated angular distance value of each patient.