Systems and methods for automatically transforming a user interface include a computer system, a first data store containing medical records, a second data store containing one or more data models, and a communications network operatively coupling the computer system, the first data store, and the second data store. The computer system may be configured to automatically extract a term from the medical records, identify a first medical concept related to the term, identify an intervention related to the first medical concept, identify a second medical concept related to the intervention, and transform the user interface by generating an interactive node corresponding to the second medical concept. The user interface may display a first popup in response to an input cursor being placed over the interactive node. The first popup may display detailed information generated based on the second medical concept.

Systems and methods for automatically transforming a user interface include a computer system, a first data store containing medical records, a second data store containing one or more data models, and a communications network operatively coupling the computer system, the first data store, and the second data store. The computer system may be configured to automatically extract a term from the medical records, identify a first medical concept related to the term, identify an intervention related to the first medical concept, identify a second medical concept related to the intervention, and transform the user interface by generating an interactive node corresponding to the second medical concept. The user interface may display a first popup in response to an input cursor being placed over the interactive node. The first popup may display detailed information generated based on the second medical concept.

A device for compressing subject data. the device comprises a communication link, the communication link capable of receiving a set of subject data; a compression module, the compression module configured to apply a compression algorithm to the set of subject data, the compression algorithm compressing the set of subject data using a reference string of subject data; and a transmission module, the transmission module configured to transmit the compressed subject data. The device further comprising an encryption module for encrypting the subject data.

A device for compressing subject data. the device comprises a communication link, the communication link capable of receiving a set of subject data; a compression module, the compression module configured to apply a compression algorithm to the set of subject data, the compression algorithm compressing the set of subject data using a reference string of subject data; and a transmission module, the transmission module configured to transmit the compressed subject data. The device further comprising an encryption module for encrypting the subject data.

Proteases regulate a wide range of normal cellular functions where dysregulated activity is observed in various diseases. Compositions and methods use protease activity multiplexed bead-based immunoassays to profile protease activity. This platform technology integrates protease activity measurements with total protein quantification techniques. It represents a significant improvement over existing detection techniques by allowing for multiplexed, sensitive active protease measurements in complex biological samples. Exemplary multiplexed detections are realized in a single assay using a minute sample amount (e.g., 5 μl) for active recombinant MMP-1, -2, -3, -7, 9, and 12 and those same MMPs in cell culture supernatant, menstrual fluid effluent, and peritoneal aspirates. This multiplexed platform achieves high level of sensitivities equal to or better than existing leading single-plex detection strategies. It also allows for high throughput screening to identify inhibitors of proteases in complex, donor-derived samples.

A system and method for resolving data through a probabilistic data structure can include initializing a B-field data structure, inserting a key-value element into the B-field data structure, selecting at least one key query, and looking up the value of a key lookup request through the B-field data structure.

A system and method for resolving data through a probabilistic data structure can include initializing a B-field data structure, inserting a key-value element into the B-field data structure, selecting at least one key query, and looking up the value of a key lookup request through the B-field data structure.

A method for determining national crop yields during the growing season is provided. In an embodiment, a server computer system receives agricultural data records for a particular year that represent covariate data values related to plants at a specific geo-location at a specific time. The system aggregates the records to create geo-specific time series for a geo-location over a specified time. The system creates aggregated time series from a subset of the geo-specific time series. The system selects a representative feature from the aggregated time series and creates a covariate matrix for each specific geographic area in computer memory. The system determines a specific state crop yield for a specific year using linear regression to calculate the specific state crop yield from the covariate matrix. The system determines a national crop yield for the specific year using the sum of the state crop yields for the specific year nationally adjusted.

A method of determining whether a treatment substance is effective for treating a growing media containing persistent herbicides is provided. The method may include determining two or more characteristics of the treatment substance and predicting a mitigation ability of the treatment substance to mitigate phytotoxicity caused by the persistent herbicides present in the growing media based on the two or more characteristics of the treatment substance.

The present invention relates to a novel azole derivative as an apelin receptor agonist and a method for treating cardiovascular disease, diabetic disease, renal disease, hypertension, and arteriosclerosis, etc., using the same. The present invention provides a compound represented by formula (I) or a pharmacologically acceptable salt thereof wherein X.sup.1 represents —N═ or —CH═, X.sup.2 represents —CH═ or —N═, R.sup.1 and R.sup.2 each represent a C.sub.1 to C.sub.6 alkoxy group or the like, R.sup.3 represents a heteroaryl group (the heteroaryl group is optionally substituted by a methyl group or the like) or the like, and R.sup.4 represents a C.sub.1 to C.sub.6 alkylthio group or a C.sub.2 to C.sub.6 alkenyl group (the C.sub.1 to C.sub.6 alkylthio group and the C.sub.2 to C.sub.6 alkenyl group are each optionally substituted by one carboxy group or the like) or the like. ##STR00001##