Systems and methods for image space control of a medical instrument are provided. In one example, a system is configured to display a two-dimensional medical image including a view of at least a distal end of an instrument. The system can determine, based on one or more fiducials on the instrument, a roll estimate of the instrument. The system further can receive a user input comprising a heading command to change a heading of the instrument within a plane of the medical image, or an incline command to change an incline of the instrument into or out of the plane of the medical image. Based on the roll estimate and the user input, the system can generate one or more motor commands configured to cause a robotic system coupled to the medical instrument to move the robotic medical instrument.

A computer-implemented method plans a position of a tracking reference device for referencing a position in a medical environment. The method includes a determination of avoidance regions in which a tracking reference device should not be placed so as to safeguard proper tracking of the tracking reference device and/or an instrument tracking reference device which is attached to a medical instrument. The avoidance region is a region lying, from the point of view of a tracking device for tracking the tracking reference device, in the shadow of an envelope surrounding at least one medical instrument. Additionally or alternatively, an avoidance region may lie in between the position of the tracking device and the envelope to avoid a shadowing, by the tracking reference device, of an instrument tracking reference device attached to the medical instrument. Information describing the position of the at least one avoidance region is displayed to a user, and also information about the position of a region which is suitable for placement of the tracking reference device can be displayed to the user.

Systems and methods for generating patient-specific surgical guides comprising: capturing a first and second images of an orthopedic element in different reference frames using a radiographic imaging technique, detecting spatial data defining anatomical landmarks on or in the orthopedic element using a neural network, applying a mask to the orthopedic element defined by an anatomical landmark, projecting the spatial data from the first image and the second image to define volume data, applying the neural network to the volume data to generate a reconstructed three-dimensional (“3D”) model of the orthopedic element; and calculating dimensions for a patient-specific surgical guide configured to abut the orthopedic element.

Allergen exposure chambers (AECs) can be used to produce controlled exposure to allergenic and non-allergenic airborne particles but at present cannot be used for double-blind, placebo-controlled, randomized clinical trials currently required by regulatory authorities. Accordingly, inventive naturalistic exposure chambers (NECs) designed to mimic the environment(s) within which a typical user/individual is exposed are outlined. Further, reproducible controlled allergen dispersal is achieved via robotic allergen aerosolization systems (AAS) which provide automated movement of the allergen source within the AEC as well as structure for acquiring and/or aerosolizing—distributing the allergen. Robotic AAS can be used to acquire only, distribute only, or acquire and distribute. Robotic AAS may also provide aerosolization of two or more allergens in defined manner.

A uterine manipulator device includes: an elongated cannulated tube having proximal and distal ends, a cervical cup positioned on the elongated cannulated tube with a top distal portion of a first diameter and a base proximal portion of a second smaller diameter, and a balloon occluder assembly. The balloon occluder assembly can be used independently or positioned proximally from the cervical cup on the elongated cannulated tube.

Optical tracking of objects in arthroscopic surgery. Examples comprise a resection instrument system including: a handpiece; a mechanical resection device comprising a stationary outer hub, an elongate outer tube coupled to and extending away from the stationary outer hub, and a cutter disposed at a distal end of the elongate shaft, the stationary outer hub coupled to the handpiece; a fiducial array; and a sleeve connector. The sleeve connector may include: a sleeve defining a distal end, a proximal end, and a through bore, the sleeve concentrically arranged with the elongate shaft; an array connector coupled to the proximal end of the sleeve, the array connector coupled to the fiducial array.

A system can include a barrier configured to form a three-dimensional (3D) structure to define an interior volume and an exterior space and to mitigate fluid movement from the interior volume and into the exterior space thereby mitigating droplet, articulate, and aerosol movement in the flow path of the fluid from the interior volume and into the exterior space. The system can include a plurality of passages extending through the barrier to provide access from the exterior space and into the interior volume to perform the procedure on the patient or perform the study on the laboratory sample arranged in the interior volume. The barrier can be configured to be formed in the 3D structure to arrange a portion of the patient or the laboratory sample in the interior volume. The barrier can be external to the patient.

The present invention relates to an endoscope suturing device and, more specifically, to an endoscopic suturing device capable of suturing a range of incisions by using an endoscope. According to the present invention, a wide range of incisions can be continuously sutured with high suturing power by using an endoscope, the suturing procedure time can be shortened, and a suturing method using a suture can minimize leftover foreign substances in the body, and thus can prevent side effects caused by the foreign substances. In addition, by using an endoscope, suturing with high-reliability is possible regardless of the range of suture areas, and thus the present invention can be used for simple suturing procedures and various internal surgeries such as gastrointestinal reduction surgery and NOTES, which uses a natural orifice.

Systems and methods for visualizing ablated tissue are disclosed. In some embodiments, a system for imaging tissue comprising: a catheter having a distal end and a proximal end; an inflatable balloon disposed about the distal end of the catheter; and an optical housing extending from the distal end of the catheter into the balloon, the optical housing being configured to position inside the balloon a light source for illuminating a tissue outside the balloon and a camera for imaging the illuminated tissue.

Ablation visualization and monitoring systems and methods are provided. In some embodiments, such methods comprise applying ablation energy to a tissue to form a lesion in the tissue, illuminating the tissue with a light to excite NADH in the tissue, wherein the tissue is illuminated in a radial direction, an axial direction, or both, monitoring a level of NADH fluorescence in the illuminated tissue to determine when the level of NADH fluorescence decreases from a base level in the beginning of the ablating to a predetermined lower level, and stopping ablation of the tissue when the level of NADH fluorescence reaches the predetermined lower level.