A diagnostic system to analyze imaging data includes a memory configured to store hybrid imaging data of a tissue sample. The system also includes a processor operatively coupled to the memory and configured to generate a four quadrant plot based on the hybrid imaging data. Each point in the four quadrant plot corresponds to an image voxel of the tissue sample. The processor is also configured to determine one or more angle values and one or more distance values for image voxels in the four quadrant plot. The processor is further configured to identify one or more characteristics of the tissue sample based at least in part on the one or more angle values and the one or more distance values. The processor is further configured to perform a matrix analysis of the data, which can be used to identify the one or more characteristics of the tissue sample.

A medical data processing device according to an embodiment includes a processing circuit. The processing circuit applies a linear calculation of a complex number coefficient and a non-linear activation not dependent on an argument of complex numbers, to medical data having a complex value.

The invention relates to an assessing device (13) for assessing the suitability of a shape of an instrument like a guidewire for a registration of a position and shape determination device (10) like an optical shape sensing device with an imaging device (2). Curvature values being indicative of the curvature at several positions along the instrument are determined, which are used for determining shape feature values. These shape feature values are then used for determining a suitability value being indicative of the suitability of the shape of the instrument for the registration procedure, wherein an output is provided to a user based on the determined suitability value. The user can therefore modify the shape until the output indicates that the shape of the instrument is suitable for the registration, without requiring any image. This can reduce a radiation dose if the image is, for instance, an x-ray image.

A photoacoustic image generation apparatus includes: a puncture needle that generates photoacoustic waves; an ultrasound probe that detects the photoacoustic waves and reflected ultrasonic waves reflected by the transmission of ultrasonic waves; a processor that generates a color Doppler signal of a region of interest as a color Doppler measurement target, generates a photoacoustic image on the basis of the photoacoustic waves, and detects the position of a tip portion of the puncture needle on the basis of the photoacoustic image; and a controller that sets the region of interest such that the position of the tip portion of the puncture needle and a center position of the region of interest are separated from each other by a predetermined distance and sets the region of interest, following the movement of the tip portion of the puncture needle, in a state in which the distance is maintained.

Various embodiments of the disclosed technology present a structural foundation for volumetric flow reconstructions for expiratory modeling enabled through multi-modal imaging for pulmonology. In some embodiments, this integrated multi-modal system includes infrared (IR) imaging, thermal imaging of carbon dioxide (CO.sub.2), depth imaging (D), and visible spectrum imaging. These multiple image modalities can be integrated into flow models of exhale behaviors enable the creation of three-dimensional volume reconstructions based on visualized CO.sub.2 distributions over time, formulating a four-dimensional exhale model which can be used to estimate various pulmonological traits (e.g., breathing rate, flow rate, exhale velocity, nose/mouth distribution, tidal volume estimation, and CO.sub.2 density distributions). Various embodiments also enable the accurate acquisition of numerous pulmonary metrics that are then stored within distributed systems for respiratory data analytics and feature extraction through deep learning embodiments.

Uptake of hypoxia-sensitive PET tracers is dependent on tissue transport properties, specifically, distribution volume. Variability in tissue transport properties reduces the sensitivity of static PET imaging to hypoxia. When tissue transport (v.sub.d) effects are substantial, correlations between the two methods of determining hypoxic fractions are greatly reduced—that is, trapping rates k.sub.3 are only modestly correlated with tumour-to-blood ratio (TBR). In other words, the usefulness of dynamic- and static-PET based hypoxia surrogates, trapping rate k.sub.3 and TBR, in determining hypoxic fractions is reduced in regions where diffusive equilibrium is achieved slowly. A process is provided for quantifying hypoxic fractions using a novel biomarker for hypoxia, hypoxia-sensitive tracer binding rate k.sub.b, based on PET imaging data. The same formalism can be applied to model the kinetics of non-binding CT and MT contrast agents, giving histopathological information about the imaged tissue.

Offset illumination using multiple emitters in a fluorescence imaging system is described. A system includes an emitter for emitting pulses of electromagnetic radiation and an image sensor comprising a pixel array for sensing reflected electromagnetic radiation. The emitter comprises a first emitter and a second emitter for emitting different wavelengths of electromagnetic radiation. The system is such that at least a portion of the pulses of electromagnetic radiation emitted by the emitter comprises a laser mapping pattern.

Systems and techniques are described for determining at least one of a translational force or a rotational force applied by a dental appliance to a tooth or teeth of a patient. A system includes model teeth configured to represent a portion of a dental arch and receive a dental appliance, a post extending from a first end coupled to a respective tooth to a second end coupled to a base, at least one strain gauge integrally formed on a surface of the post between the first end and the second end, and processor communicatively coupled to the at least one strain gauge and configured to determine at least one of a translational force or a rotational force applied by the dental appliance to the respective tooth.

A method for detecting estrus in sows where insemination is carried out when a determination has been made. In a first method images of a rear profile of each sow are analyzed to make a determination from features relating to a shape, size, and/or color of the vulva whether the sow is in estrus. The analysis can use a program where a large number of images showing the vulva area of a plurality of sows known to be in estrus and known not to be in estrus have been previously analyzed to generate data on the previous images to create a program which generates a signal using the data to make the determination. In a second method a boar is confined and brought into close contact with the sows where images and/or sounds of each sow are analyzed to make a determination whether the sow is in estrus.

A method for detecting demineralization of a tooth substance, including the steps of irradiating (S101) a structured light pattern onto the tooth substance; detecting (S102) a light intensity of the light pattern remitted from the volume of the tooth substance; and determining (S103) demineralization of the tooth substance based on the detected light intensity.