The underlying invention comprise a method for changing the human perceptual color appearance of the iris of a human's or animal's eye by selectively decreasing the density of pigments of the anterior stroma layer of the iris, the method comprising the steps of generating a plurality of predefined energy quantities; applying one or more of the predefined energy quantities to the anterior stroma layer, wherein each of the predefined energy quantities is generated and applied such that it ablates at least in part melanocytes of the stroma, wherein the predefined energy quantities at least in part are generated and applied in such a way that ablated tissue generated as an immediate cause of the energy quantities is discharged into the anterior eye chamber such that the discharged tissue can be removed by maintaining a mechanically generated flow of rinsing solution through or within the anterior eye chamber.

The underlying invention comprise a method for changing the human perceptual color appearance of the iris of a human's or animal's eye by selectively decreasing the density of pigments of the anterior stroma layer of the iris, the method comprising the steps of generating a plurality of predefined energy quantities; applying one or more of the predefined energy quantities to the anterior stroma layer, wherein each of the predefined energy quantities is generated and applied such that it ablates at least in part melanocytes of the stroma, wherein the predefined energy quantities at least in part are generated and applied in such a way that ablated tissue generated as an immediate cause of the energy quantities is discharged into the anterior eye chamber such that the discharged tissue can be removed by maintaining a mechanically generated flow of rinsing solution through or within the anterior eye chamber.

A method for creating an animal model of indirect traumatic optic neuropathy, including fully exposing an internal segment of an optic canal as well as adjacent anterior skull base, posterior ethmoid sinus and lateral sphenoid sinus walls through an ethmoid sinus-sphenoid sinus operation pathway under an endoscope, and impacting different sites of the internal segment of the optic canal with controllable impact force to cause optic nerve injury so as to prepare a controllable and quantifiable ITON bionic elastic injury animal model reflecting contusion to an internal segment of an optic canal in a human ITON clinical injury state. With less intracranial combined injury to the animal, the survival rate is high. Different sites of the optic canal are impacted with quantifiable elastic force for the quantitative and qualitative purposes with respect to the injured parts and the injury degree.

A method for creating an animal model of indirect traumatic optic neuropathy, including fully exposing an internal segment of an optic canal as well as adjacent anterior skull base, posterior ethmoid sinus and lateral sphenoid sinus walls through an ethmoid sinus-sphenoid sinus operation pathway under an endoscope, and impacting different sites of the internal segment of the optic canal with controllable impact force to cause optic nerve injury so as to prepare a controllable and quantifiable ITON bionic elastic injury animal model reflecting contusion to an internal segment of an optic canal in a human ITON clinical injury state. With less intracranial combined injury to the animal, the survival rate is high. Different sites of the optic canal are impacted with quantifiable elastic force for the quantitative and qualitative purposes with respect to the injured parts and the injury degree.

A method for occluding a blood vessel has steps for encasing a semi-rigid, circular plastic ring, open at one point, in silicon material, forming a bladder along an inside diameter of the silicon material, placing a mixture of sodium and potassium salts and polyacrylamide granules in the bladder, closing and sealing the bladder, forming a pair of opposed stirrups on an outside diameter of the silicon material, spreading the encased plastic ring by the stirrups accomplishing an opening through the ring of an extent enabling the ring to be placed over a blood vessel, placing the encased plastic ring over the blood vessel, releasing the stirrup, allowing the ring and bladder to close around the blood vessel, such that the bladder, constrained by the ring from expanding outward, absorbing moisture by osmosis over time, expands inward, and over a time t fully occludes the blood vessel.

A method for occluding a blood vessel has steps for encasing a semi-rigid, circular plastic ring, open at one point, in silicon material, forming a bladder along an inside diameter of the silicon material, placing a mixture of sodium and potassium salts and polyacrylamide granules in the bladder, closing and sealing the bladder, forming a pair of opposed stirrups on an outside diameter of the silicon material, spreading the encased plastic ring by the stirrups accomplishing an opening through the ring of an extent enabling the ring to be placed over a blood vessel, placing the encased plastic ring over the blood vessel, releasing the stirrup, allowing the ring and bladder to close around the blood vessel, such that the bladder, constrained by the ring from expanding outward, absorbing moisture by osmosis over time, expands inward, and over a time t fully occludes the blood vessel.

An occlusion apparatus has a plastic ring with an opening at one point, encased in silicone, with a central opening of a first inside diameter, a silicone bladder in the circular, central opening, providing a hollow, semi-circular silicone ring, a mixture of sodium and potassium salts and polyacrylamide granules at a specific ration of materials enclosed in the silicone bladder, and two stirrups, one affixed on one side and the other opposite the first. The stirrups and the opening provide for spreading the apparatus by the stirrups to place the apparatus over a blood vessel, releasing the apparatus enclosing the blood vessel in the second inside diameter of the bladder, and wherein water passing through walls of the silicone bladder forms a hygroscopic gel that expands over time with further absorption of water, closing the second inside diameter of the silicone bladder, slowly occluding the blood vessel.

The invention relates to a tissue sampler for taking samples of tissue from animal's or plants. The tissue sampler is adapted to hold a storage tube in which a tissue sample is to be placed and to hold a magazine comprising one or more collecting devices. Each collecting device comprises a punch for cutting a tissue sampler and a plunger for pushing the tissue sample into the storage tube. The magazine can be moved after each tissue sample is taken so that a fresh collection device is ready to take the next tissue sample. The invention also relates to a magazine comprising a plurality of collecting devices for use with the tissue sampler.

The present invention provides an implant in a form of a truss, spanning the distance from diaphysis of the tibia to the tip of the calcaneus, thus fixing the ankle (hock) joint in extension. Gastrocnemius muscles are thus at close to their shortest length and their force capacity is greatly reduced, preventing the caudal luxation of the distal femur even if the cranial cruciate ligament is torn.

The present invention provides an implant in a form of a truss, spanning the distance from diaphysis of the tibia to the tip of the calcaneus, thus fixing the ankle (hock) joint in extension. Gastrocnemius muscles are thus at close to their shortest length and their force capacity is greatly reduced, preventing the caudal luxation of the distal femur even if the cranial cruciate ligament is torn.