Disclosed are methods, systems, media, apparatus, devices, and other implementations, including a method that includes determining blood flow characteristics at an ocular surface of an eye of a patient, determining characteristics of blood vessels at the ocular surface of the eye based on the determined blood flow characteristics, and deriving one or more ocular redness grading scales indicative of inflammation levels of the eye of the patient based on the determined characteristics of the blood vessels at the ocular surface of the eye.

An ocular implant (10) for conveying intraocular fluid away from a site of excess intraocular fluid within a patient, the implant (10) including: a body (12) including one or more drainage channels (20) each having an outlet (24) fluidly communicable with drainage site located away from the site of excess intraocular fluid; and an elongated tubular member (30) fluidly communicable with the body (12), the member (30) having a first end portion (32) providing an inlet (38), a second end portion (34) providing an end (40), and a lumen extending between the inlet (38) and the end (40), wherein the inlet (38) is fluidly communicable with the site of excess intraocular fluid so that the intraocular fluid is able to flow past the inlet (38) and through the lumen towards the end (40), and wherein the second end portion (34) includes one or more openings (42) each fluidly communicable with a respective one of the one or more drainage channels (20) to permit the intraocular fluid to flow from the second end portion (34) to each of the outlets (24).

An injector includes a push rod, a magazine tube, a gate, a cannula and an actuator. The magazine tube has a lumen extending from an inlet to an outlet thereof. The magazine tube slidingly receives at least one implant therein. The gate has a closed configuration in which it covers the outlet of the magazine tube and an open configuration in which it does not cover the outlet of the magazine tube. The cannula has a distal end configured to be inserted into an eye. A lumen of the cannula is in fluid communication with the lumen of the magazine tube when the gate is in the open configuration. Actuation of the actuator moves the gate from the closed configuration to the open configuration and causes translation of the pushrod through the magazine tube and the cannula.

A synthetic eye model is provided which can include a number of features. In one embodiment, the synthetic eye can include a rigid or semi-rigid eye shell, a synthetic iris base positioned within the eye shell, an eye core positioned within the eye shell and encircling the synthetic iris base, the eye core including a channel integral to the eye core configured to replicate Schlemm's canal of a human eye, and a synthetic trabecular meshwork tissue coupled to the eye shell and extending across the channel. Methods of using the synthetic eye model are provided, including using the synthetic eye model as a surgical training tool.

Described here are systems and methods for accessing Schlemm's canal and for delivering an ocular device or fluid composition therein. The ocular devices may maintain the patency of Schlemm's canal without substantially interfering with transmural fluid flow across the canal. The fluid composition may be a viscoelastic fluid that is delivered into the canal to facilitate drainage of aqueous humor by disrupting the canal and surrounding trabeculocanalicular tissues. Tools for disrupting these tissues and minimally invasive methods for treating medical conditions associated with elevated intraocular pressure, including glaucoma, are also described.

An implantable device having a reservoir for the sustained release of therapeutic agents. The device is configured to be at least partially implanted in an eye and include a retention structure and a penetrable element coupled to and extending within at least a portion of the proximal end region of the device. The device includes a porous drug release element is positioned in fluid communication with an outlet of the device and a reservoir having a volume configured to contain one or more therapeutic agents in fluid communication with the outlet through the porous drug release element. The device is at least partially inserted along an axis of insertion.

Systems and methods are provided for in vivo pre-surgical characterization of lenses, such as cataractous lenses. A method comprises obtaining an electromagnetically-measured value related to the axial thickness of the lens, obtaining an ultrasound-measured value related to the axial thickness of the lens, calculating a relationship value based upon the electromagnetically-measured value and the ultrasound-measured value, and determining a mechanical property value based upon the calculated relationship value. The mechanical property may relate to lens hardness, rigidity, or density, or the amount of energy for a phacoemulsification procedure. A system may comprise an optical interferometer for measuring data to obtain the electromagnetically-measured value and an ultrasound biometer for measuring data to obtain the ultrasound-measured value.

A liquid dispensing device includes a multifunction membrane valve that, in addition to allowing the dispensing of drops with a drop-check mechanism, ensures and isolates the passage of the air to be filtered so that it does not contaminate the liquid in the interior of the dispensing device; it has a reduced number of parts; it facilitates proper assembly by counter pressure, without the need for threads or complex coupling elements; it avoids the need for rotational alignment when assembling the parts, among other advantages.

A device may be configured to be located underneath an eyelid for treating ophthalmic conditions. The device may include an annular body and a flex circuit mounted on and conforming to at least a portion of an outer surface of the annular body. The flex circuit may include a substrate comprising an electronic circuitry portion and one or more electrode portions, and electronic circuitry attached to the electronic circuitry portion of the substrate. The flex circuit may further include one or more electrodes bonded to the substrate at the one or more electrode portions and electrically coupled to the electronic circuitry. An orientation around the annular body of each of the one or more electrodes may be based on a position on the substrate of a respective electrode portion of the one or more electrode portions.

In certain embodiments, a system for making an implant for an eye comprises a laser, a camera, and a computer. The laser emits a laser beam to shape a material. The camera generates one or more images to monitor shaping of the material. The computer stores a pattern for the implant, which is designed to provide refractive treatment for the eye; sends instructions to the laser to control the laser beam to shape the material according to the pattern; assesses the images from the camera according to the pattern; and adjusts the instructions in response to the images.