Systems and methods of providing an expandable and conforming interbody implant are described. According to some implementations, an interbody implant includes a first surface configured to be disposed adjacent to a first bony endplate, and a second surface configured to be disposed adjacent to a second body endplate, with a height of the interbody implant extending between the first surface and the second surface. According to some implementations, the interbody implant is configured to be selectively disposed in an insertion configuration and a deployed configuration. In some cases, the height of the interbody implant is greater in the deployed configuration than in the insertion configuration. Moreover, in some cases, the first surface is configured to conform to a topology of the first bony endplate, and the second surface is configured to conform to a topology of the second bony endplate.

A prosthesis includes a stent frame, a valve structure positioned within the stent frame, and a plurality of guides spaced apart in series along a helical track. Each guide of the plurality of guides comprises a distinct opening. Methods also provide at least a portion of a helical elongated member being received within a plurality of corresponding openings of a plurality of guides formed by a track of a prosthesis to radially compress at least a portion of the prosthesis from a radially expanded arrangement to a radially compressed arrangement.

A system for managing female incontinence includes a body of biocompatible material configured to fit between the labia minora and the vestibule floor, the body having a surface configured to occlude the urethral meatus, an adhesive carried on at least a first portion of the surface and configured to provide a sealing engagement between the body and the urethral meatus, and a substance carried by at least one of the body and the adhesive and configured for controlling the odor of the general vaginal-urethral area of a female.

A replacement heart valve system includes a replacement heart valve implant including an expandable framework and a plurality of leaflets, wherein the framework includes an attachment tab extending upstream from an inflow end, and an implant delivery system including an implant holding portion including a stent holder configured to engage the attachment tab to axially secure the implant relative to the delivery system. The stent holder includes a first radiopaque marker, and the attachment tab includes a second radiopaque marker, the first and second markers may collectively indicate a rotational orientation of the framework relative to a native heart valve under fluoroscopy. The first radiopaque marker may indicate when a middle commissure post of the framework is disposed in a posterior position and an anterior position relative to a native heart valve under fluoroscopy in a 3-cusp view.

A transcatheter heart valve includes a paravalvular seal that is configured for transfemoral delivery. The valve includes a frame and the seal is formed from a plurality of outwardly extending fibers.

A transcatheter heart valve includes a paravalvular seal that is configured for transfemoral delivery. The valve includes a frame and the seal is formed from a plurality of outwardly extending fibers.

A transcatheter valve prosthesis including a tubular stent includes an interior skirt or skirt portion is coupled to and covers an inner circumferential surface of the stent, and an exterior skirt or skirt portion is coupled to and covers an outer circumferential surface of the stent. A prosthetic valve component is disposed within and secured to the interior skirt or skirt portion. The interior and exterior skirts or skirt portions may overlap to form a double layer of skirt material on the stent, or may be portions of a skirt that do not overlap such that only a single layer of skirt material covers the stent. When the stent is in at least the compressed configuration, at least one endmost crown may be positioned radially inwards with respect to the remaining endmost crowns formed at the inflow end of the stent in order to accommodate the exterior skirt.

Systems and methods of providing one or more conforming interbody implants, implants with one or more conforming regions, or related implants are described. According to some implementations, an interbody implant includes a first surface configured to be disposed adjacent to a first bony endplate, and a second surface configured to be disposed adjacent to a second body endplate, with a height of the interbody implant extending between the first surface and the second surface. According to some implementations, the interbody implant is configured to be selectively disposed in an insertion configuration and a deployed configuration. In some cases, the height of the interbody implant is greater in the deployed configuration than in the insertion configuration. Moreover, in some cases, the first surface is configured to conform to a topology of the first bony endplate, and the second surface is configured to conform to a topology of the second bony endplate.