The disclosure relates to an ophthalmological instrument with a main body and at least one ligand (L) immobilized on the main body. In the implanted state of the ophthalmological implant, the ligand (L) binds and/or deactivates at least one fibrinogen and/or cytokine. The disclosure further relates to a method for producing an ophthalmological implant, and to a use of a ligand (L), via which at least one fibrinogen and/or cytokine is to be bound and/or deactivated in the implanted state of the ophthalmological implant, for producing an ophthalmological implant.

A transcatheter heart valve includes a paravalvular seal that is configured for transfemoral delivery. The valve includes an outer frame and the seal is formed from a plurality of outwardly extending fibers.

An endovascular heart valve assembly includes an inner frame comprising a graft covering housing a prosthetic heart valve, an outer frame formed from a metallic material and defining a gridded configuration. A sealing material includes a plurality of radially extending fibers that extend outwardly of the outer frame. The plurality of radially extending fibers include first fibers extending from a first position relative to the outer frame and second fibers extending from a second position relative to the outer frame that is distally spaced-apart from the first position. The gridded configuration includes an uncovered open cell between the first position and the second position. The first fibers and the second fibers are configured to cooperatively form a seal when compressed within the aortic annulus. A length of the first fibers is greater than a height of the uncovered open cell.

An implantable vein frame is contemplated in which two ring members are rigidly joined in spaced axial alignment via one or more interconnecting members. One of the one or more interconnecting members defines a protruding region that acts upon the implant placed within the frame and/or the vein that the vein frame is placed within to define a sinus region. The implant is placed within and scaffolded by the vein frame, and the vein frame is subsequently inserted within a vein via a venotomy, or interposed between two vein segments via vein interposition graft. The vein frame acts to support the structural integrity of the implant, and to scaffold and anchor the implant in place with the vein.

The technology defined in the present document generally relates to a method for enhancing hair growth on an area of a skin of a subject. The method comprises topically applying a composition comprising at least one light-absorbing molecule to the skin; and exposing said applied composition to actinic light to cause activation of the composition. Activation of the applied composition triggers enhancement of hair growth on the skin.

Disclosed are methods, devices and materials for the in situ formation of a nerve cap to inhibit neuroma formation following planned or traumatic nerve injury. The method includes the steps of identifying a severed end of a nerve, and positioning the severed end into a cavity defined by a form. A transformable media is introduced into the form cavity to surround the severed end. The media is permitted to undergo a transformation from a first, relatively flowable state to a second, relatively non flowable state to form a protective barrier surrounding the severed end. The media may be a hydrogel, and the transformation may produce a synthetic crosslinked hydrogel protective barrier. The media may include at least one anti-regeneration agent to inhibit nerve regrowth

A transcatheter valve assembly replacement device includes a paravalvular seal that includes outwardly extending fibers that create a seal with the annulus when the valve assembly is deployed.

An endovascularly deployed prosthetic includes a portion for being positioned within an ascending aorta. The prosthesis includes a replacement aortic valve on a proximal end thereof. The prosthesis includes an increased diameter portion that seals against the aorta at a more distal portion, and a pair of conduits extend from the increased diameter portion to the coronaries for fluidly coupling the coronaries to the prosthesis.

A transcatheter aortic valve replacement (TAVR) device includes a paravalvular seal that includes outwardly extending fibers that create a seal with the aortic annulus when the TAVR is deployed.

Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. By removing the epithelium layer, cells from the host can more readily interact with the cell-adhesion bio-active factors located onto top and within of the basement membrane. Also described herein are methods for making and using the tissue grafts. The laminin structure of amnion tissue is nearly identical to that of native human tissue such as, for example, oral mucosa tissue. This includes high level of laminin-5, a cell adhesion bio-active factor show to bind gingival epithelia-cells, found throughout upper portions of the basement membrane.