A permeable spraying device for making drug tablets mainly comprises a carrying platform, a spraying equipment, a flattening device and a control equipment, the carrying platform defines a powder dropping area and a flattened spraying area, and a moving device combined with the carrying platform is capable of moving vertically. The spraying equipment is mounted above the carrying platform, and the spraying equipment comprises a powder box, a colloid spraying equipment, a driving device and a placement platform. The placement platform is disposed with a plurality of supplementary colloid carriers. The flattening device is installed on the carrying platform and moves horizontally back and forth in the flattened spraying area. The control equipment is equipped with a storage unit and an execution control unit. A multi-layer drug body structure can be formed by deposition, stacking and bonding.

Solid, stable formulations of linaclotide suitable for oral administration are described herein as are methods for preparing such formulations. The formulations described herein contain a polypeptide consisting of the amino acid sequence Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr (“linaclotide”; SEQ ID NO:1) or a pharmaceutically acceptable salt thereof. The linaclotide formulations described herein are stable and have a sufficient shelf life for manufacturing, storing and distributing the drug.

Solid, stable formulations of linaclotide suitable for oral administration are described herein as are methods for preparing such formulations. The formulations described herein contain a polypeptide consisting of the amino acid sequence Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr (“linaclotide”; SEQ ID NO:1) or a pharmaceutically acceptable salt thereof. The linaclotide formulations described herein are stable and have a sufficient shelf life for manufacturing, storing and distributing the drug.

An exemplary compounding system and device for mixing materials can include a housing, a first material source and a second material source. A first fluid line can be operationally connected to the housing and configured to transport a first volume of fluid per unit time from the first material source to a final container. A second fluid line can be operationally connected to the housing and configured to transport a second volume of fluid per unit time from the second material source to the final container. The device can also include a pump system including, a first pump having a first rotor and a first platen which secures the first fluid line between the first rotor and the first platen, the first pump being configured to move the first volume of fluid through the first fluid line, and a second pump having a second rotor and a second platen which secures the second fluid line between the second rotor and the second platen, the second pump being configured to move the second volume of fluid through the second fluid line. A first platen lock can be provided and can be rotated in a first direction to lock the first platen in a closed position relative to the first rotor, and wherein rotation of the first rotor draws the first material source through the first fluid line. The pump system can also be configured such that the volume of fluid per unit time delivered by the first and second pumps is different, and/or where the first and second pumps have different head characteristics.

A single-dose composition and related kits and methods, including powder mannitol at an amount from 50 to 200 grams, wherein the powder mannitol has a bulk density ranging from 0.4 g/ml to 0.65 g/ml is described. A percentage ranging from 90% to 100% by weight of the particles of powder mannitol has a particle size distribution ranging from 1 μm to 500 μm.

A conveyor capable of detecting a cut line of portion packaging bags, and a medicine inspection support system are provided. The conveyor conveys the portion packaging bags to an inspecting machine, the portion packaging bags being divided one by one with use of a heat seal portion and perforations by a portion packaging machine and being continuously discharged in a longitudinal posture from the portion packaging machine. The conveyor includes a posture changing device configured to change the longitudinal posture of the portion packaging bags to a lateral posture; and a detector configured to detect a cut line of the portion packaging bags.

A method of producing a tablet in which an uncoated tablet is coated by a coating agent, the method including: a coating process of coating uncoated tablets with a coating agent by spray coating the coating agent onto tablets that are churned and tumbled inside a container, and drying the tablets inside the container by supplying drying air into the container and exhausting air from the container, wherein spray coating conditions, including air supply temperature, air supply rate, and spray speed, are controlled according to the weight of the coating agent with which the uncoated tablets are coated, such that the humidity of air exhausted during spray coating is within a range of from 14% RH to 30% RH.

A medicine feeder includes: an outer rotary body on the outer side to be rotated about a vertical line; an inner inclined rotary body on the inner side to be rotated about an inclined line; and a sorting mechanism and a regulating mechanism operable to align solid medicine pieces carried from the top of the inner inclined rotary body onto an annular upper end surface of the outer rotary body through rotation of the inner inclined rotary body. An upper surface inclined portion of the inner inclined rotary body includes delivery portions sloping downward toward the outer side even at an elevated position and push-up portions not sloping downward toward the outer side, the delivery portions and the push-up portions being formed alternately in the circumferential direction. The push-up portions include projecting portions. The projecting portions are extended to the inner peripheral side of the delivery portions.

A medicine feeder includes: an outer rotary body on the outer side to be rotated about a vertical line; an inner inclined rotary body on the inner side to be rotated about an inclined line; and a sorting mechanism and a regulating mechanism operable to align solid medicine pieces carried from the top of the inner inclined rotary body onto an annular upper end surface of the outer rotary body through rotation of the inner inclined rotary body. An upper surface inclined portion of the inner inclined rotary body includes delivery portions sloping downward toward the outer side even at an elevated position and push-up portions not sloping downward toward the outer side, the delivery portions and the push-up portions being formed alternately in the circumferential direction. The push-up portions include projecting portions. The projecting portions are extended to the inner peripheral side of the delivery portions.

Various aspects of the subject disclosure relate to a compounder system having a cartridge that includes controllable fluid pathways. One or more rotary piston pump/valves may be used to move fluid and/or gasses through the various fluid pathways of the cartridge. For example, the cartridge may include a dedicated rotary piston pump/valve for each process that moves fluid and/or gas through the cartridge. When turning, the rotary piston pump/valve acts as a pump to move the fluid or gas, and when the rotary piston pump/valve stops turning, it effectively acts as a shutoff valve, preventing any fluid flow. Magnetic couplers for the cartridge may be provided on a pump head of the compounder system.