Chitosan nanoparticles are provided for use in the in vivo treatment of connective tissues in root canal therapies. The nanoparticles are optionally linked with one or more photoactivatable compounds for providing antibacterial/antibiofilm properties, neutralizing bacterial byproducts and/or chemical/photodynamic crosslinking to achieve enhanced mechanical properties, chemical stability in connective tissues and/or to improve surface/interfacial integrity between filling material and connective tissue.

A dental curable composition capable of use as a dental material that can substitute part or all of a natural tooth, in particular, a resin material for dental cutting and machining in the field of dental care. When a block shape usable as the resin material is produced, while mechanical properties and aesthetic properties required for a crown prosthetic appliance are maintained, the dental curable composition can be molded and processed with pressure and heating while strain generated in the block is reduced and no cracks and chipping occur. The dental curable composition includes (a) a polymerizable monomer and (b) a filler in a weight ratio of 10:90 to 70:30, and 0.01 to 10 parts by weight of (c) a polymerization initiator and 0.001 to 1 part by weight of (d) a chain transfer agent being a terpenoid compound based on 100 parts by weight of the polymerizable monomer (a).

In one embodiment, the present application discloses a surface binding compound of the Formula I or Formula II: ##STR00001##
wherein the variables EG, EG1, SP1, SP2, SP3, Ar and BG are as defined herein. In another embodiment, the application discloses a method for forming a coating on a surface of a substrate using the surface binding compound of the Formula I or Formula II.

The present invention relates to a composition of an intracanal medication agent for medicating root canals for a predetermined period of time. According to one aspect of the invention, there is provided an intracanal medication composition based on a calcium hydroxide component, comprising: calcium hydroxide or a calcium hydroxide producing component as a powder component; and at least one of diethyl sulfoxide (DMSO), N-methyl-2-pyrrolidone (NMP) and diethylene glycol monoethyl ether (DEGEE) as a liquid component.

The present invention relates to novel liquid pharmaceutical compositions of adalimumab, which include adalimumab or a biosimilar thereof, an acetate buffering agent/system such as sodium acetate/acetic acid, and a sugar stabiliser such as trehalose. Such a combination of components furnishes formulations having a stability (e.g. on storage and when exposed to stress) which is comparable to or an improvement upon those known in the art, and with fewer ingredients. Such advances will help adalimumab treatments to become more widely available at lower cost, and prolong the viability of pre-loaded delivery devices (e.g. pre-filled syringes) to reduce unnecessary waste of the drug.

The invention relates to a medical composition comprising guanidinyl-containing polymer(s) and polyanionic polymer(s). The medical composition is useful for absorbing water-containing fluids and can be used as dental retraction composition or as part of a medical treatment device.

The present invention provides a dental cleaner that provides desirable cleanliness against contamination of dental restorations and abutment teeth due to protein-containing body fluids while ensuring uniform quality by reducing precipitation of salts, and that ensures desirable bond durability after cleaning while being safe to use in the oral cavity. The present invention relates to a dental cleaner comprising an acidic group-containing radical polymerizable monomer (a), water (b), and an organic amine compound (c). The present invention also relates to a dental remover for temporary adhesives comprising an acidic group-containing compound (A), water (B), and a basic compound (C).

To provide a dental composition wherein the acid buffering capacity can be attained and the acid resistance of the tooth substance can be improved while maintaining very high foul breath inhibition capacity. A dental composition including: ion sustained-release glass; and a carrier for supporting the ion sustained-release glass, wherein the ion sustained-release glass is fluoroaluminoborosilicate glass having a composition range of: 15% to 35% by mass SiO.sub.2; 15% to 30% by mass Al.sub.2O.sub.3; 5% to 20% by mass B.sub.2O.sub.3; 20% to 45% by mass SrO; 5% to 15% by mass F; and 0% to 10% by mass Na.sub.2O.

Dentifrice compositions comprising zinc ion, glycine and fluoride ion source, especially in the absence of stannous ion source, are provided for treating dental plaque biofilm.

An edible chew is formulated for oral consumption by a human child and includes an expanded pre-gelatinized cereal flour matrix. A method of (i) providing teething support to a human child who is teething and/or (ii) soothing, calming and/or delivering an active ingredient to a human child can include administering the edible chew to the human child. Methods of making the edible chew are provided, for example by modified extrusion; and also a system including the edible chew and further including a holder configured to attach to the edible chew; a product including a packaging and further including the edible chew; and a product including a container housing a plurality of the edible chews, and the plurality of edible chews are individually packaged.