An oral care composition containing a gel phase, potassium nitrate, an abrasive, and a fluoride source. The gel network phase contains a cold dispersible fatty amphiphile and phase separation is not visually perceptible in the oral care composition.

A curable composition contains one or more betaine monomers selected from the group consisting of a compound represented by Formula (1) and a compound represented by Formula (2).

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Two-part dual-curing dental compositions containing a hydroperoxide, a thiourea derivative and an acetylacetonate salt as redox radical initiator system, are provided. The dental compositions may contain an acidic monomer for use as a self-adhesive cement. The dental compositions possess enhanced shelf-life stability for working/setting time, bonding strength, color stability, slump, flexural strength/modulus, and when kept at 50 C. for more than 16 weeks.

Provided are methods of detecting tooth stain prevention and/or removal comprising the steps of providing pellicle-coated hydroxyapatite particles, contacting the particles with a first solution and then a second solution, wherein the first solution is either a test solution or a stain solution and the second solution is the other of said test solution or stain solution, separating from the resulting particles a liquid comprising stain introduced in the contacting step b), and measuring the UV-Vis absorbance of the separated liquid to determine the amount of stain in the liquid.

This present invention compositions and methods of treating cancer and methods of accessing/monitoring the responsiveness of a cancer cell to a therapeutic compound.

Provided is a dental pretreatment material for dental tissue regeneration by use of dental pulp stem cells, particularly a dental pretreatment material effectively enabling dental tissue regeneration even by use of dental pulp stem cells of middle-aged or older individuals. The dental pretreatment material is characterized by comprising a serine protease, specifically trypsin. The dental pretreatment material comprising trypsin is used as an injection into a root canal before a root canal filling material comprising dental pulp stem cells and an extracellular matrix is inserted into the root canal as an attempt to regenerate a dental pulp and a dentin. The root canal filling material includes an ALK5 inhibitor, a CCR3 antagonist, or a CCL11 neutralizing antibody.

Provided is a dental pretreatment material for dental tissue regeneration by use of dental pulp stem cells, particularly a dental pretreatment material effectively enabling dental tissue regeneration even by use of dental pulp stem cells of middle-aged or older individuals. The dental pretreatment material is characterized by comprising a serine protease, specifically trypsin. The dental pretreatment material comprising trypsin is used as an injection into a root canal before a root canal filling material comprising dental pulp stem cells and an extracellular matrix is inserted into the root canal as an attempt to regenerate a dental pulp and a dentin. The root canal filling material includes an ALK5 inhibitor, a CCR3 antagonist, or a CCL11 neutralizing antibody.

Described herein are directed to dental filler particles and methods of making the same. The dental filler particles include a polymer coating with a plurality of ethylenically unsaturated groups on the surface of the coating. Also described herein are dental restorative materials comprising the particles.

A microcapsule composition comprising at least one polymer substantially disposed as a semi-permeable shell around an aqueous buffered solution and at least one agent, wherein the agent permeates the shell, and wherein the composition is suitable for delivery to a mammal. This invention also provides related compositions, products and methods.

The present invention provides a self-adhesive dental composite resin maintaining mechanical strength, showing excellent storage stability, undergoing little change in transparency and properties of the paste during long-term storage, and having a small solidification risk during long-term storage. The present invention relates to a self-adhesive dental composite resin comprising: an acid group-containing (meth)acrylic polymerizable monomer (a); a polyfunctional (meth)acrylic polymerizable monomer (b) containing no acid group; a photopolymerization initiator (c); and a filler (d), wherein the filler (d) is treated with a surface treatment agent and has an average particle diameter of 0.01 to 50.0 m, the surface treatment agent comprises a silane coupling agent (A) represented by the following general formula (1):

CH.sub.2C(R.sup.1)COO(CH.sub.2).sub.pSiR.sup.2.sub.qR.sup.3.sub.(3-q)(1), and

an organosilazane (B) represented by the following general formula (2):

R.sup.4R.sup.5R.sup.6SiNHSiR.sup.7R.sup.8R.sup.9(2).