Systems for preserving a cosmetic formulation and for preventing growth or survival of microorganisms on a cosmetic formulation include a cosmetic container and a cosmetic formulation disposed therein and having an argon gas reservoir which is formed within the cosmetic formulation such that rupturing the reservoir releases argon gas onto an adjacent cosmetic-air interface and displaces oxygenated air therefrom. Methods for manufacturing and preserving a cosmetic formulation include preparing a cosmetic formulation that is free of exogenous chemical preservatives but may contain natural preservatives, forming the argon gas reservoir, and sealing a container containing the cosmetic formulation in a nonvacuum, argon gas environment to form an argon gas blanket in the container headspace. The argon gas reservoir can be formed as microbubbles or a chimney of argon gas disposed vertically in the container or as other discrete pockets within the formulation and/or container.

Personal care products, such as shampoos, conditioners, hair dyes, hair removal products, cleansers, cosmetics, mascaras, and toothpastes may be formulated to include one or more surfactants, from one or more surfactant classes, such as siloxane derivatives of amino acids that have surface-active properties.

According to the present invention there is provided a cosmetic composition comprising a cosmetically acceptable carrier and a surfactant system consisting of: (i) an anionic surfactant; (ii) an amphoteric surfactant; and (iii) a non-ionic surfactant, wherein the anionic surfactant is present in an amount of from about 0.5% to about 25% by weight of the surfactant system, wherein the amphoteric surfactant is present in an amount of from about 0.5% to about 50% by weight of the surfactant system, wherein the non-ionic surfactant is present in an amount of from about 0.5% to about 45% (e.g. 43%) by weight of the surfactant system, and wherein the total amount of the surfactant system present in the cosmetic composition is from about 1.5% to about 25% by weight of the composition.

A personal cleansing composition includes a surfactant system, wherein the surfactant system includes from 0.1% to 5% of a fatty acyl isethionate surfactant by weight of the composition; from 0.5% to 40% of a co-surfactant by weight of the composition; from 0.05% to 5% of a natural polysaccharide or a chemically modified natural polysaccharide by weight of the composition; wherein the personal cleansing composition includes a first and second phase, wherein the first phase is an isotropic and micellar surfactant phase; wherein the second phase is a polymer liquid crystalline phase; wherein the composition is free of alkyl sulfate and alkyl ether sulfate type of surfactants; wherein the composition exhibits a yield stress value τ.sub.y from 0.005 Pa to 3 Pa; and wherein the composition exhibits a flow viscosity from 3 Pa.Math.s to 100 Pa.Math.s at 25° C. at a shear rate of 1.5 s.sup.−1.

An oil-in-water type emulsion is characterized in that a fumed silica particle group in which lower order aggregates are aggregated with each other to form a higher order aggregate by a non-chemical bond forms a network-like surrounding structure including an oil inside the network-like surrounding structure.

Provided herein are in vivo gelling ophthalmic pre-formulations forming a biocompatible retinal patch comprising at least one nucleophilic compound or monomer unit, at least one electrophilic compound or monomer unit, and optionally a therapeutic agent and/or viscosity enhancer. In some embodiments, the retinal patch at least partially adheres to the site of a retinal tear. Also provided herein are methods of treating retinal detachment by delivering an in vivo gelling ophthalmic pre-formulation to the site of a retinal tear in human eye, wherein the in vivo gelling ophthalmic pre-formulation forms a retinal patch.

The purpose of the present invention is to newly provide a method with which it is possible to appropriately evaluate the protective effect of an external preparation for skin such as a sunscreen cosmetic, particularly to evaluate how a UV-ray protective effect is affected by heat. This evaluation method is characterized by including (1) a step for forming a coating film of an external preparation for skin on a substrate, (2) a step for heat-treating the coating film of the external preparation for skin, and (3) a step for measuring the UV-ray protective effect of the heat-treated coating film of the external preparation for skin. The heat treatment is preferably carried out for at least one minute at a temperature of 30-70° C. The step for measuring the UV-ray protective effect preferably includes at least one selected from testing methods that involve comparing some kind of UV-ray protective effect with SPF measurement, UVAPF or PFA measurement, critical wavelength measurement, absorbance measurement, and transmittance measurement. This evaluation method can also be performed in vivo or in vitro.

A cleansing composition comprising a detersive surfactant; an aqueous carrier; from about 0.5% to about 30% by weight of the cleansing composition of discrete particles comprising anhydrous particles and an aqueous phase, and wherein said anhydrous particles comprise: one or more fatty amphiphile selected from the group consisting of fatty alcohol, fatty ester, fatty acid, fatty amide and mixtures thereof; of one or more secondary surfactants selected from the group consisting of anionic, nonionic, zwitterionic, cationic or mixtures thereof. Wherein the discrete particle of the cleansing composition has a size from about 500 microns to about 7000 microns, and wherein the cleansing composition has a % transmittance of about 75% or higher.

A subcritical liquid extraction process for the production of oleandrin or oleandrin-containing extract is provided. The process provides improvements over other methods of preparing oleandrin-containing extract. The extract, pharmaceutical compositions, dosage forms and nutraceutical compositions comprising oleandrin or said extract are provided. Methods of treating diseases, disorders or conditions that are therapeutically responsive to oleandrin are also provided.

The invention relates to stable, mild and moisturizing lamellar liquid cleansing compositions which possess a lotion-like appearance conveying signals of enhanced moisturization. However, these liquids often are either unstable or cause poor lather production and other sensory deficits The use of a specific ratio of total acyl isethionates to acyl glutamates or other divalent anionic surfactant in a structured liquid product improve stability and lather production, mildness and acceptable odor.