Described herein are methods, devices and systems for stimulating neural oscillations in the high gamma wave frequency, in particular to promote neuronal plasticity and removal of the perineuronal net. Such methods, devices and systems are useful for treating neuropsychiatric disorders such as schizophrenia and depression in a subject in need thereof.

Magnetosomes for use in a sequential laser radiation medical treatment, wherein the magnetosomes are administered to a body part of an individual. In a first step, the magnetosomes are irradiated by a laser radiation, and in a second step, the magnetosomes are irradiated by a laser radiation of lower power than in the first step or no laser irradiation of the magnetosomes is performed. The sequence of the first step and second step is repeated at least once.

Reagents and methods to cloak and uncloak RNA polymers and applications thereof are provided. Photocloaking molecules are used to label RNA polymers. Radiant energy is used to remove photoreleaseable protecting adducts and revert a RNA polymer to its native form.

Apparatus and systems describe a plasma source to generate cold plasma solution for use in hospital, home, office, and other locations. The plasma source employs air, gas, and/or vapor discharging in a high voltage electric field, which interact to obtain plasma solution for oral health. The plasma source may include power supply, plasma generator, liquid container, liquid aerosolizer/vaporizer or liquid disturber, reservoir, collector, and intelligent control center.

A nanocomposite includes an oxygen vacancy-containing BiOX particle and a coating, where the coating is a biocompatible material. Under near-infrared (NIR) irradiation, the nanocomposite has a photothermal conversion efficiency of greater than or equal to 10%. Under NIR irradiation, the nanocomposite degrades 1,3-diphenylisobenzofuran (DPBF) at a rate of higher than or equal to 0.1 mmol/h. BiOX may be BiOF, BiOCl, BiOBr, BiOI, or BiOAt. A preparation method and a use of the nanocomposite are further provided. The nanocomposite is a bismuth oxyhalide nanomaterial with different numbers of oxygen vacancies and can be used for the photothermal therapy (PTT) of a tumor and for the integrated tumor diagnosis and treatment. The nanocomposite leads to an excellent therapeutic effect under the guidance of multi-modality imaging, and has excellent computed tomography (CT) imaging and photoacoustic imaging (PAI) performance.

The present invention relates to antigen binding sites, compositions and uses thereof in the treatment of conditions associated with pathogenic proteins. In one example the condition is Alzheimer's disease.

Some embodiments provide a system for external manipulation of magnetic nanoparticles in vasculature using a remotely placed magnetic field-generating stator. In one aspect, the systems and methods relate to the control of magnetic nanoparticles in a fluid medium using permanent magnet-based or electromagnetic field-generating stator sources. Such a system can be useful for increasing the diffusion of therapeutic agents in a fluid medium, such as a human circulatory system, which can result in substantial clearance of fluid obstructions, such as vascular occlusions, in a circulatory system resulting in increased blood flow.

Some embodiments provide a system for external manipulation of magnetic nanoparticles in vasculature using a remotely placed magnetic field-generating stator. In one aspect, the systems and methods relate to the control of magnetic nanoparticles in a fluid medium using permanent magnet-based or electromagnetic field-generating stator sources. Such a system can be useful for increasing the diffusion of therapeutic agents in a fluid medium, such as a human circulatory system, which can result in substantial clearance of fluid obstructions, such as vascular occlusions, in a circulatory system resulting in increased blood flow.

A monocyte, monocyte derived cell or macrophage infected with an oncolytic herpes simplex virus is disclosed together with uses of such infected cells in the treatment of diseases such as cancer.

A monocyte, monocyte derived cell or macrophage infected with an oncolytic herpes simplex virus is disclosed together with uses of such infected cells in the treatment of diseases such as cancer.