Disclosed are compounds, for example, a compound of formula I, wherein R, R.sub.0, R.sub.1-R.sub.8, n, X, Y, Y′, and E are as described herein, pharmaceutical compositions containing such compounds, and methods of treating or preventing a disease or condition for example, cancer, mediated by the ras gene. ##STR00001##

The present invention relates to a FoxM1 gene splicing modifier selected from a compound of formula (I) or of formula (VI) ##STR00001## wherein A and B are as defined herein, or a pharmaceutically acceptable salt thereof, for use in the treatment, prevention and/or delay of progression of cancer.

The present invention relates to a FoxM1 gene splicing modifier selected from a compound of formula (I) or of formula (VI) ##STR00001## wherein A and B are as defined herein, or a pharmaceutically acceptable salt thereof, for use in the treatment, prevention and/or delay of progression of cancer.

To provide a method for forming a transparent coating that is highly adherent to the skin and through which the skin is visible.

A method for forming a coating on a skin surface using a nanofiber sheet, the method comprising:

(1) Step (1) of applying to the skin a sheet transparentizing agent comprising 2 mass or more of one or more oil agents; and

(2) Step (2) of transferring a white nanofiber sheet mainly composed of a water-insoluble polymer to the skin after Step (1).

A method of treating human skin, hair and/or mucous membranes using a personal care composition in the form of a stable oil-in-water emulsion comprising: (i) a continuous aqueous phase comprising water; (ii) a discontinuous oil phase comprising trans-1-chloro-3,3,3-trifluoropropene and/or trans-1-3,3,3-tetrafluoropropene and when present together are present in a trans1233zd:trans1234ze weight ratio of from about 1:18 to less than about 8:1; and (iii) an emulsifier, which may be present in the continuous and/or discontinuous phase, comprising (a) a non-ionic emulsifier having an HLB of from about 7 to about 19; and/or (b) a polymeric emulsifier.

The present invention relates to compounds of Formulas I-IV, which are salts of special lipid mediators of inflammation, compositions containing same, and methods of using same in the treatment of various diseases and disorders characterized by chronic or excessive inflammation, or both. Provided are pharmaceutical compositions adapted to deliver the compounds the lower gastrointestinal tract and methods of using same as monotherapy in the treatment of inflammatory diseases or disorders of the lower gastrointestinal tract, and in combination therapy with 5-aminosalicylate.

Compositions and methods are disclosed for repairing damaged keratin fibers or otherwise strengthening keratin fibers, including hair of the human scalp, and particularly hair that has been damaged chemically, physically, thermally or by other means. The compositions comprise 3,3-thiodipropionic acid (TDPA) or a derivative thereof in a cosmetically acceptable vehicle.

Disclosed are compounds, for example, a compound of formula I,

##STR00001##

wherein R, R.sub.0, R.sub.1-R.sub.8, n, X, Y, Y, and E are as described herein, pharmaceutical compositions containing such compounds, and methods of treating or preventing a disease or condition for example, cancer, mediated by the ras gene.

Disclosed are compounds, for example, a compound of formula I,

##STR00001##

wherein R, R.sub.0, R.sub.1-R.sub.8, n, X, Y, Y, and E are as described herein, pharmaceutical compositions containing such compounds, and methods of treating or preventing a disease or condition for example, cancer, mediated by the ras gene.

The present invention relates to compounds of Formulas I-IV, which are salts of special lipid mediators of inflammation, compositions containing same, and methods of using same in the treatment of various diseases and disorders characterized by chronic or excessive inflammation, or both.