A method of treating human skin, hair and/or mucous membranes using a personal care composition in the form of a stable oil-in-water emulsion comprising: (i) a continuous aqueous phase comprising water; (ii) a discontinuous oil phase comprising trans-1-chloro-3,3,3-trifluoropropene and/or trans-1-3,3,3-tetrafluoropropene and when present together are present in a trans1233zd:trans1234ze weight ratio of from about 1:18 to less than about 8:1; and (iii) an emulsifier, which may be present in the continuous and/or discontinuous phase, comprising (a) a non-ionic emulsifier having an HLB of from about 7 to about 19; and/or (b) a polymeric emulsifier.

The present invention relates to a FoxM1 gene splicing modifier selected from a compound of formula (I) or of formula (VI)

##STR00001## wherein A and B are as defined herein, or a pharmaceutically acceptable salt thereof, for use in the treatment, prevention and/or delay of progression of cancer.

The present invention relates to a FoxM1 gene splicing modifier selected from a compound of formula (I) or of formula (VI)

##STR00001## wherein A and B are as defined herein, or a pharmaceutically acceptable salt thereof, for use in the treatment, prevention and/or delay of progression of cancer.

Compositions and methods are disclosed for repairing damaged keratin fibers or otherwise strengthening keratin fibers, including hair of the human scalp, and particularly hair that has been damaged chemically, physically, thermally or by other means. The compositions comprise 3,3-thiodipropionic acid (TDPA) or a derivative thereof in a cosmetically acceptable vehicle.

The present invention relates to compounds of Formulas I-IV, which are salts of special lipid mediators of inflammation, compositions containing same, and methods of using same in the treatment of various diseases and disorders characterized by chronic or excessive inflammation, or both.

Disclosed are compounds, for example, a compound of formula I, ##STR00001##
wherein R, R.sub.0, R.sub.1-R.sub.8, n, X, Y, Y, and E are as described herein, pharmaceutical compositions containing such compounds, and methods of treating or preventing a disease or condition for example, cancer, mediated by the ras gene.

Disclosed are compounds, for example, a compound of formula I, ##STR00001##
wherein R, R.sub.0, R.sub.1-R.sub.8, n, X, Y, Y, and E are as described herein, pharmaceutical compositions containing such compounds, and methods of treating or preventing a disease or condition for example, cancer, mediated by the ras gene.

Disclosed are compounds, for example, a compound of formula I, wherein R, R.sub.0, R.sub.1-R.sub.8, n, X, Y, Y, and E are as described herein, pharmaceutical compositions containing such compounds, and methods of treating or preventing a disease or condition for example, cancer, mediated by the ras gene.

##STR00001##

Disclosed are compounds, for example, a compound of formula I, wherein R, R.sub.0, R.sub.1-R.sub.8, n, X, Y, Y, and E are as described herein, pharmaceutical compositions containing such compounds, and methods of treating or preventing a disease or condition for example, cancer, mediated by the ras gene.

##STR00001##

The present invention is directed to a method for treating the appearance of thinning hair of a human comprising the steps of; cleaning the hair with a shampoo composition; rinsing said shampoo from said hair; and applying a hair restorative blend to the scalp of said human, said hair restorative blend comprising; a chalconoid, an Epilobium extract, a Laminaria extract and a cosmetically acceptable carrier.