Absorbable composite medical devices such as surgical meshes and braided sutures, which display two or more absorption/biodegradation and breaking strength retention profiles and exhibit unique properties in different clinical settings, are made using combinations of at least two types of yarns having distinctly different physicochemical and biological properties and incorporate in the subject construct special designs to provide a range of unique properties as clinically useful implants.

Surgical constructs, assemblies and methods for tissue reinforcement with a reinforcement (reinforcing) material such as suture, tape, weave, ribbon or mesh, among many others. The reinforced construct includes a reinforced section that prevents a suture from pulling apart. The reinforced section is be a piece of material (a reinforcement or reinforcing material) such as reinforced stitched suture tape attached to a flexible strand. A needle attached to the flexible strand terminating with the reinforced section passes through a proximal end of the reinforced section to form an adjustable starter loop. The starter loop is slid and positioned over tissue (for example, graft, tendon, ligament, etc.) and the suture is pulled apart to tighten the loop around the tissue.

Surgical constructs, assemblies and methods for tissue reinforcement with a reinforcement (reinforcing) material such as suture, tape, weave, ribbon or mesh, among many others. The reinforced construct includes a reinforced section that prevents a suture from pulling apart. The reinforced section is be a piece of material (a reinforcement or reinforcing material) such as reinforced stitched suture tape attached to a flexible strand. A needle attached to the flexible strand terminating with the reinforced section passes through a proximal end of the reinforced section to form an adjustable starter loop. The starter loop is slid and positioned over tissue (for example, graft, tendon, ligament, etc.) and the suture is pulled apart to tighten the loop around the tissue.

Compositions are provided that have at least two of three active ingredients. The active ingredients maybe a salt having a cation N.sup.C8-C16 alkanoyl-L di-basic amino acid C1-C4 alkyl ester, a glycerol monoester of a fatty acid and a sugar ester of a fatty acid. The compositions are useful in methods of killing or inhibiting planktonic bacteria or fungi and bacteria or fungi embedded in a biofilm and prevention of biofilm formation on surfaces. The composition may further comprise a hydrogel and a benefit agent such as an antibiotic that can be solubilized by the hydrogel and supplied to the biofilm matrix by the active ingredients of the composition. Devices such as chronic wound coverings coated with the composition are also provided. Methods of preserving products with the composition are also provided.

Provided are an alloy member which is usable in organisms, makes use of features of bio-affinity and biodegradability of magnesium, and is able to realize required duration of biodegradability, and a production method therefor. According to the present invention, the alloy member usable in organisms includes a base body that contains a magnesium alloy, a first protective layer that contains an oxide derived from a component of the base body or a complex of an oxide and a hydroxide derived from a component of the base body, and a second protective layer that contains a hydroxide derived from a component of the base body.

Provided are an alloy member which is usable in organisms, makes use of features of bio-affinity and biodegradability of magnesium, and is able to realize required duration of biodegradability, and a production method therefor. According to the present invention, the alloy member usable in organisms includes a base body that contains a magnesium alloy, a first protective layer that contains an oxide derived from a component of the base body or a complex of an oxide and a hydroxide derived from a component of the base body, and a second protective layer that contains a hydroxide derived from a component of the base body.

Disclosed herein are compositions to use in biofouling-resistant coatings, biofouling-resistant coatings, methods of making biofouling-resistant coatings, biofouling-resistant devices, and methods of making biofouling-resistant devices.

A staple cartridge assembly comprising a tissue thickness compensator is disclosed. The tissue thickness compensator comprises a first fibrous, woven material and a second fibrous, woven material. The first fibrous, woven material comprises a density which is different than the density of the second fibrous, woven material. The tissue thickness compensator is configured to expand upon contact with a fluid in order to apply a compressive force to tissue captured within staples.

A staple cartridge assembly comprising a tissue thickness compensator is disclosed. The tissue thickness compensator comprises a first fibrous, woven material and a second fibrous, woven material. The first fibrous, woven material comprises a density which is different than the density of the second fibrous, woven material. The tissue thickness compensator is configured to expand upon contact with a fluid in order to apply a compressive force to tissue captured within staples.

A staple cartridge assembly comprising a tissue thickness compensator is disclosed. The tissue thickness compensator comprises a first fibrous, woven material and a second fibrous, woven material. The first fibrous, woven material comprises a density which is different than the density of the second fibrous, woven material. The tissue thickness compensator is configured to expand upon contact with a fluid in order to apply a compressive force to tissue captured within staples.