Hydrogel compositions prepared from amine components and glycidyl ether components are provided which are biocompatible and suitable for use in vivo due, in part, to their excellent stability.

The present disclosure describes drug-loaded nanoparticles for hepatic artery chemoembolization, wherein the drug-loaded nanoparticles are novel doxorubicin-loaded metal organic framework (MOF) nanoparticles and UiO-66/Bi.sub.2S.sub.3 nanocomposites. The preparation method of the drug-loaded nanoparticles includes the following steps: mixing UiO-66/Bi.sub.2S.sub.3 with DOX solution, stirring the resultant mixture overnight at 25° C.±5° C. in a dark environment, centrifuging the mixture, and washing with deionized water to obtain UiO-66/UiO-66/Bi.sub.2S.sub.3@DOX composite nanomaterials. The present disclosure adopts a “one-pot reaction” with a simple preparation process. The pH-reactive release performance of the MOF material indicates that the tumor tissue of hepatocellular carcinoma (HCC) has a lower pH than normal tissue, and the acidic tumor environment can induce the release of doxorubicin from the nanomaterials. The MOF material has strong photothermal conversion ability, allowing HCC to be treated by photothermal treatment in combination with TACE.

The present technology provides a composition comprising a mixture of a source of calcium ions, alginate conjugated to an acrylate monomer (ALG-A), carboxymethylcellulose conjugated to an acrylate monomer (CMC-A) and water, wherein the mixture is a shear-thinning gel. The compositions may further include a polythiol agent. Such compositions are injectable due to their shear-thinning properties, yet stay in place, undergo in situ crosslinking, and provide safe, simple and efficacious endovascular embolization. Methods of making and using such compositions are also provided.

Described herein are polymeric particles configured for intravascular delivery of pharmaceutical agents, e.g., to a diseased site, and methods of forming and using same. Preparation of these polymer particles is also described.

Blockchain environments may mix-and-match different encryption, difficulty, and/or proof-of-work schemes when mining blockchain transactions. Each encryption, difficulty, and/or proof-of-work scheme may be separate, stand-alone programs, files, or third-party services. Blockchain miners may be agnostic to a particular coin's or network's encryption, difficulty, and/or proof-of-work schemes, thus allowing any blockchain miner to process or mine data in multiple blockchains. GPUs, ASICs, and other specialized processing hardware components may be deterred by forcing cache misses, cache latencies, and processor stalls. Hashing, difficulty, and/or proof-of-work schemes require less programming code, consume less storage space/usage in bytes, and execute faster. Blockchain mining schemes may further randomize byte or memory block access, further improve cryptographic security.

The present invention is directed to bioresorbable polymers to be used as bone and tissue adhesives. The present invention is also directed to the synthesis of bioresorbable polymeric molecules bearing adhesive moieties and the use of such compounds in methods to glue and stabilize fractured bones and damaged tissues. The present invention is also directed to the use of such compounds as adhesive sealants for applications in wound care. The present invention is also directed to the use of such compounds as biodegradable ink for applications in tissue engineering and 3D printing. The present invention also relates to the use of such compounds as drug delivery platforms.

The invention features adhesive devices for holding objects (e.g., bone fragments) fixed with respect to each other.

There are provided herein bioadhesive compositions which include at least one catechol derivatives, such as, caffeic acid derivatives, and at least one synthetic thermoplastic polymer, wherein exposure to heat causes the bioadhesive composition to transform into a non-solid state and to cohesively adhere to a biological tissue upon subsequent cooling. Further provided are methods of making the compositions and uses thereof in repairing tissue damage, such as, for example, in hernia repair surgeries.

Medical devices, such as orthopedic medical implants, and corresponding methods of applying a porous coating to the medical device are disclosed. In some embodiments, a medical device may include a plurality of texture features extending from a base surface, and a porous coating applied into and atop of the plurality of texture features and the base surface. The porous coating may include a plurality of coating structures, wherein a first coating structure group of the plurality of coating structures has a first size, wherein a second coating structure group of the plurality of coating structures has a second size, and wherein the first size is different than the second size.

A method and apparatus are provided for making a temporary hip joint prosthesis. The method includes horizontally positioning each half of a two-part mold having a respective impression of a front side and a backside of a hip joint prosthesis. The method includes level filling the selected impressions with a bone cement mixture. The method includes rotating one half of the two-part mold to align the front side and back side of the hip joint prosthesis. The method includes maintaining the two halves of the two-part mold in contact as portions of the bone cement mixture in each half adhere together and cures. The method includes removing a hip joint prosthesis from the two-part mold.