The present invention relates to a hydrophobic antimicrobial agent comprising a mineral material, which is surface coated with a copper and/or silver salt of at least one fatty acid, a method for its manufacture, wherein at least one fatty acid and at least one copper and/or silver salt are dissolved in a non-aqueous solvent, the solutions are combined, the copper and/or silver salt of the at east one fatty acid is precipitated by adding water, separated, and surface coated onto the mineral material. Furthermore, the present invention relates to the hydrophobic antimicrobial agent obtained by said method, the use thereof as a filler, products comprising the hydrophobic antimicrobial agent, and the use of a copper and/or silver salt of at least one fatty acid for surface coating a mineral material.

The present invention relates to a hydrophobic antimicrobial agent comprising a mineral material, which is surface coated with a copper and/or silver salt of at least one fatty acid, a method for its manufacture, wherein at least one fatty acid and at least one copper and/or silver salt are dissolved in a non-aqueous solvent, the solutions are combined, the copper and/or silver salt of the at east one fatty acid is precipitated by adding water, separated, and surface coated onto the mineral material. Furthermore, the present invention relates to the hydrophobic antimicrobial agent obtained by said method, the use thereof as a filler, products comprising the hydrophobic antimicrobial agent, and the use of a copper and/or silver salt of at least one fatty acid for surface coating a mineral material.

The present invention provides a controlled release formulation comprising a silicone substrate which comprises a compound of Formula (I): AA-AA-AA-X—Y. The invention further provides methods of making these formulations, medical devices such as dressings incorporating said formulations and medical uses thereof.

The present invention provides a controlled release formulation comprising a silicone substrate which comprises a compound of Formula (I): AA-AA-AA-X—Y. The invention further provides methods of making these formulations, medical devices such as dressings incorporating said formulations and medical uses thereof.

The invention generally relates to VHH domains that specifically bind a severe acute respiratory syndrome coronavirus spike protein receptor binding domain, corresponding expression vectors and host cells, and methods of treatment using such VHH domains.

The invention generally relates to VHH domains that specifically bind a severe acute respiratory syndrome coronavirus spike protein receptor binding domain, corresponding expression vectors and host cells, and methods of treatment using such VHH domains.

The invention relates to the use of an organometallic coordination complex or its phytopharmaceutically acceptable salt of a M.sup.m+ metal and of at least one L ligand, where M.sup.m+ is a transition metal having an oxidation number m, L is a ligand of general formula (VII) or its anion, wherein R.sup.1 is selected from the group consisting of oxygen, mono or polycyclic alkyl, naphthalene residue, anthracene residue and their hydroxylated or ketone derivatives; R.sup.2 and R.sup.3 are identical or different and are selected independently of each other from hydrogen, halogen, a hydroxyl group, an alkoxy group, a linear or branched alkyl group, a cycloalkyl group or R.sup.2 and R.sup.3 together forming a benzene derivative; R.sup.6, R.sup.7 and R.sup.8 are identical or different and independently of each other are selected from hydrogen, a hydroxyl group, an alkoxy group, a linear or branched alkyl group, a cycloalkyl group, a phenyl group, an aryl group in the treatment of Xylella fastidiosa in a plant. The invention also concerns the use of the compound of formula (VII) in the treatment of Xylella fastidiosa in a plant, also in combination with the organometallic coordination complex. Advantageously, the invention concerns the treatment of olive trees.

The invention relates to the use of an organometallic coordination complex or its phytopharmaceutically acceptable salt of a M.sup.m+ metal and of at least one L ligand, where M.sup.m+ is a transition metal having an oxidation number m, L is a ligand of general formula (VII) or its anion, wherein R.sup.1 is selected from the group consisting of oxygen, mono or polycyclic alkyl, naphthalene residue, anthracene residue and their hydroxylated or ketone derivatives; R.sup.2 and R.sup.3 are identical or different and are selected independently of each other from hydrogen, halogen, a hydroxyl group, an alkoxy group, a linear or branched alkyl group, a cycloalkyl group or R.sup.2 and R.sup.3 together forming a benzene derivative; R.sup.6, R.sup.7 and R.sup.8 are identical or different and independently of each other are selected from hydrogen, a hydroxyl group, an alkoxy group, a linear or branched alkyl group, a cycloalkyl group, a phenyl group, an aryl group in the treatment of Xylella fastidiosa in a plant. The invention also concerns the use of the compound of formula (VII) in the treatment of Xylella fastidiosa in a plant, also in combination with the organometallic coordination complex. Advantageously, the invention concerns the treatment of olive trees.

A substrate with a pathogen inhibiting treatment. The substrate comprising a first coating of an inorganic material. The inorganic material being applied to the substrate via a vapour deposition process. A second coating applied at an upper surface of the first coating, and wherein the second coating is at least one of a protective coating for the first coating and a functional coating.

A substrate with a pathogen inhibiting treatment. The substrate comprising a first coating of an inorganic material. The inorganic material being applied to the substrate via a vapour deposition process. A second coating applied at an upper surface of the first coating, and wherein the second coating is at least one of a protective coating for the first coating and a functional coating.