The present invention relates to a dry process for isolating clean glandular trichomes from a trichome bearing plant material, wherein the trichome bearing plant material is frozen at −20° C. and subject to shattering and softening sequence.

A horizontal axis rotary separation apparatus is deployed in a process for separating resinous trichomes rich in flavoring, aromatic and/or medicinal components produced in plant trichome glands from unwanted plant matter. The process physically separates resin rich beads at the trichome gland head from extraneous plant matter by one or move separation sieves. The sieves are provided in or as a casing over a rigid frame member. The sieves are mesh fabric bags or screen that are easily opened and replenished in a batch operating mode, and are removable from the frame for cleaning and maintenance. Other aspects of the invention include processes that improve process efficiency and speed, and yield products of superior quality.

The present invention refers to the use of an extract from chestnut shells (CSE), peeling waste of the chestnut, (fruit of the tree Castanea sativa Mill., European Chestnut), or fractions of said extract, with specific antiviral activity in the treatment and/or prevention of Herpesviridae, Retroviridae, and Coronaviridae infections.

The invention relates to an extract of Ashwagandha that exhibit enhanced bioactivity and bioavailability comprising of enriched withanolide glycosides and saponins; with negligible amount of alkaloids, withanolide aglycones and oligosaccharides. The extract as disclosed prepared from root, stems, leaves and whole plant of Ashwagandha further shows improved immunomodulatory activity, anti-inflammatory activity, anti stress activity, antidiabetic activity and sleep quality. The disclosure also provides a method of improving bioactivity of withanolide glycosides even at lower doses, by the administration of an enteric coated formulation of extract of Ashwagandha to humans. The enteric coating protects the composition from hydrolysis in the acidic environment of the stomach to release the withanolide glycoside in neutral/ alkaline pH in gastrointestinal tract (GIT) thus enhancing the absorption. Further the process of preparation of the extract of Ashwagandha enriched with withanolide glycosides and saponins are disclosed along with various formulations.

An object of the present invention is to provide a purified Salacia genus plant extract that has reduced bitter taste and/or reduced astringent taste, in which the content of salacinol contained in the extract is not reduced during purification and the concentration of salacinol contained in the extract is maintained, and a production method therefor. According to the present invention, there are provided a purified Salacia genus plant extract in which the content of epicatechin and the content of epigallocatechin are each less than 0.001% by mass with respect to the total amount of the purified Salacia genus plant extract; and a production method for a purified Salacia genus plant extract, which includes an extraction step of passing a Salacia genus plant-containing raw material extract containing at least one of a Salacia genus plant, a Salacia genus plant extract, or a Salacia genus plant ground product, through a column packed with a styrene-based synthetic resin.

The present invention relates to the technical field of natural medicines, and in particular to a triterpenoid compound with an effect of improving glucose and lipid metabolism disorders, and preparation and application thereof. A novel triterpenoid compound was obtained by separation from Momordica charantia L. for the first time in the present invention. Studies on a mouse primary hepatocyte model and a 3T3-L1 preadipocyte model show that the novel triterpenoid compound in the present invention has activity of regulating glucose and lipid metabolism, and after combination with known triterpenoid compound Momordicoside G, the activity of regulating glucose and lipid metabolism is significantly higher than that of a single compound at the same dose, indicating that the novel triterpenoid compound and a complex thereof in the present invention can be used to improve glucose and lipid metabolism disorders and provide a new way for diabetes treatment.

A drug delivery system is provided for transdermally administering a psychedelic active agent to a subject to provide continuous microdose plasma levels of the active agent or a metabolite thereof during an extended drug delivery time period. The transdermal drug delivery system comprises a drug reservoir that houses a formulation containing the active agent, a combination of a solubilizer-type permeation enhancer and a plasticizer-type permeation enhancer, and a pH stabilizing agent. The pH stabilizing agent brings the pH of the formulation, at the system-skin interface, and/or within the skin as the active agent is transported across the skin from the skin surface to the bloodstream, to within 25% of the pKa of the active agent. Formulations and methods of use are also provided.

The present invention relates to herbal compositions comprising the botanicals from the Palauan medicinal plants. Examples of these botanicals include but are not limited to; Astronidium palauense, Averrhoa bilimbi, Flacourtia rukam, Gmelina palawensis, Hedyotis korrorensis, Lygodium microphyllum, Manilkara udoido, Morinda pedunculata, Osmoxylon oliveri, Phaleria nisidai, or Premna obtusfolia, or extracts thereof, which are useful in treating liver diseases, particularly those with viral etiology. The compositions of the invention have demonstrated outstanding efficacy in the treatment of patients with hepatic disorders. Compositions of the present invention have also inhibited the activities of liver-damaging virus activities, such as HCV. The preferred compositions contain the botanical ingredients comprising the fatty acids or the phenolic constituents from the Palauan medicinal plants.

This invention relates to novel products of compressed Cannabis flower for medicinal and/or recreational use, and for methods of making such products.

A fractionation method, pure active compounds and derivatives thereof, compositions including the same and methods of treating cancer including administering such compounds, derivatives, compositions or any combination thereof. A fractionation method of a Cyathus striatus CBS 126585 for obtaining at least one of the pure active ingredients Striatal C, Striatal C′ or Striatal D, wherein the fractionation method includes: providing an octadecyl silica gel column; and performing a series of RP-18 preparative chromatography steps using the acetadecyl silica gel column.