An automated modular filtration system, particularly for low volume tangential flow filtration processes, comprises a plurality of filtration modules formed as separate assemblies and at least one control unit for jointly controlling filtration processes of individual filtration units. Each filtration module contains at least one individual filtration unit for executing a filtration process independent of the other filtration units, first input ports for receiving a first type of fluids, second input ports for receiving a second type of fluids, and exit ports for outputting unused system fluids. First type fluids are process fluids are specific to the filtration processes executed in individual filtration units. Second type fluids are system fluids not specific to filtration processes executed in the individual filtration units. The second input and exit ports establish inter-module connections so system fluids can be forwarded from one filtration module to an adjacent filtration module of the filtration system.

A liquid filter cartridge is provided. Preferred seal arrangements are provided, to provide for preferred axial load conditions, with respect to one or more of the end caps of the cartridge. Some cartridge configurations provided include no core structure or outer liner structure therein, to support axial load. Assemblies using the cartridge, and methods of assembly and use, are provided. The liquid filter cartridge can be a serviceable cartridge, or it can be retained permanently in a housing.

A filter module for sterile filtration and virus filtration of fluid media. The filter module includes a filter membrane with a porous edge structure arranged thereon and at least one anchoring element. The filter membrane with the porous edge structure is embedded in the anchoring element and serves as edge reinforcement to improve the connection of the filter membrane to the anchoring element. The texturing or surface roughness of the edge reinforcement provides an interlocking effect between the filter membrane and the anchoring element. The embedding of the filter membrane in the anchoring element provides a fluid-tight connection of the membrane to the anchoring element which prevents the occurrence of leaks in the end region of the filter module. A method for producing the filter module is also described.

Provided are spacers, ion-exchange devices comprising spacers, and methods of preparing spacers for improved fluid distribution and sealing throughout an ion-exchange device. These spacers can include an internal cavity surrounded by a perimeter of the spacer. The perimeter can have a first opening and a second opening within the perimeter, and the first opening and the second opening can be located on opposite sides of the internal cavity. The spacers can also have a first and second plurality of channels located within the perimeter, wherein each channel of the first and second plurality of channels extends from the internal cavity towards the first opening or the second opening.

Disclosed is a hollow fiber filter arrangement and a bioreactor system comprising such a hollow fiber filter arrangement. The hollow fiber filter arrangement comprising: an inlet for receiving a sample to be filtered in the hollow fiber filter arrangement; an outlet for delivering of the filtered sample out from the hollow fiber filter arrangement; a bundle of elongate hollow fibers connected at a first end to the inlet and connected at an opposite second end to the outlet; and an outer housing enclosing the bundle, wherein a filtrate/waste collection space is provided between the outer housing and the at least one elongated hollow fiber, and wherein the outer housing is made from a flexible material.

Disclosed is a hollow fiber filter arrangement and a bioreactor system comprising such a hollow fiber filter arrangement. The hollow fiber filter arrangement comprising: an inlet for receiving a sample to be filtered in the hollow fiber filter arrangement; an outlet for delivering of the filtered sample out from the hollow fiber filter arrangement; a bundle of elongate hollow fibers connected at a first end to the inlet and connected at an opposite second end to the outlet; and an outer housing enclosing the bundle, wherein a filtrate/waste collection space is provided between the outer housing and the at least one elongated hollow fiber, and wherein the outer housing is made from a flexible material.

The invention concerns a set of tubular elastic coupling bodies arranged opposing at inlet and outlet of a filter cartridge.

The tubular elastic end coupling, comprises a tube end adapted to fit on the filter cartridge inlet/outlet. The elastic end coupling comprises one or more tubular fluid connections for conveying fluid to and from external means for fluid content separation purposes by said membrane filter cartridge.

A separation membrane module includes a separation membrane complex having a support and a separation membrane provided on the support, a housing container for housing the separation membrane complex, and a sealing member existing between a supporting surface provided inside the housing container and a supported surface of the separation membrane complex, being in close contact with the supporting surface and the supported surface. A first static friction coefficient between the sealing member and the supported surface and/or a second static friction coefficient between the sealing member and the supporting surface are/is not higher than 0.5. A value obtained by multiplying the first static friction coefficient and/or the second static friction coefficient by a compressive force [N] of the sealing member and dividing the product by a mass [kg] of the separation membrane complex is larger than 0.7.

A membrane element having a filtration main body, a header (a water collection portion) that collects treated water from an end portion of the filtration main body and a treated water lead-out portion that leads out the treated water is used. The treated water lead-out portion is connected to a tubular peripheral wall of a water collection pipe that collects treated water solid-liquid-separated by the membrane element, and communicates with an inside of the tubular peripheral wall. The tubular peripheral wall has a thick portion that is thicker in a horizontal direction at an upper-side peripheral wall portion located at an upper side (or at a lower-side peripheral wall portion located at a lower side) in the radial direction of the tubular peripheral wall, and a connecting hole that penetrates the thick portion.

A cartridge for non-cryogenically separating a gas into components includes a plurality of hollow polymeric fibers, the fibers being anchored by a pair of tubesheets, each tubesheet being adjacent to a head, the tubesheet and head being joined by a clamshell retainer. The cartridge does not have a core tube. The fibers are enclosed within a sleeve, the sleeve being sufficiently thin so as to be a non-structural element. The cartridge may be inserted within a larger pressure vessel. The cartridge of the present invention can accommodate more fibers than comparable cartridges of the prior art, and therefore has greater throughput.