A method of minimizing material mixing in a piping system during a transition between a first material and a second material includes providing a plurality of pipe pigs in a first pipe section with the plurality of pipe pigs being sufficient to substantially fill a cross-section of the first pipe section and to define a plug having a leading edge and a trailing edge such that the leading edge is in contact with a first material and the trailing edge is in contact with a second material. Each pipe pig has a nominal size that is smaller than an effective diameter of the first pipe section. The plug is moved through the piping system by moving the second material. Advantageously, mixing of the first material and the second material is inhibited by the plug.

A vacuum powered pickup tool with mechanically moveable discrete nozzles allows for selective activation of the nozzles through the mechanical movement of the nozzles relative to a vacuum manifold. The movement of a nozzle from an inactive position where an inlet port of the nozzle is fluidly decoupled with the vacuum manifold to an active position where the inlet port is fluidly coupled with the vacuum manifold allows for independent activation of discrete nozzles of the pickup tool. Aspects also contemplate varying an associate manifold through movement of the manifolds accessible to the inlet port of the nozzle when in the active position.

A vacuum powered pickup tool with mechanically moveable discrete nozzles allows for selective activation of the nozzles through the mechanical movement of the nozzles relative to a vacuum manifold. The movement of a nozzle from an inactive position where an inlet port of the nozzle is fluidly decoupled with the vacuum manifold to an active position where the inlet port is fluidly coupled with the vacuum manifold allows for independent activation of discrete nozzles of the pickup tool. Aspects also contemplate varying an associate manifold through movement of the manifolds accessible to the inlet port of the nozzle when in the active position.

A vacuum powered pickup tool with mechanically moveable discrete nozzles allows for selective activation of the nozzles through the mechanical movement of the nozzles relative to a vacuum manifold. The movement of a nozzle from an inactive position where an inlet port of the nozzle is fluidly decoupled with the vacuum manifold to an active position where the inlet port is fluidly coupled with the vacuum manifold allows for independent activation of discrete nozzles of the pickup tool. Aspects also contemplate varying an associate manifold through movement of the manifolds accessible to the inlet port of the nozzle when in the active position.

A vacuum powered pickup tool with mechanically moveable discrete nozzles allows for selective activation of the nozzles through the mechanical movement of the nozzles relative to a vacuum manifold. The movement of a nozzle from an inactive position where an inlet port of the nozzle is fluidly decoupled with the vacuum manifold to an active position where the inlet port is fluidly coupled with the vacuum manifold allows for independent activation of discrete nozzles of the pickup tool. Aspects also contemplate varying an associate manifold through movement of the manifolds accessible to the inlet port of the nozzle when in the active position.

Microfluidic devices and methods for focusing components in a fluid sample are described herein. The microfluidic device has at least one flow focusing channel where the components are focused or re-oriented by the geometry of the channel. From an upstream end of the flow focusing channel to a downstream end of the flow focusing channel, at least a portion of the flow focusing channel has a reduction in height and at least a portion of the flow focusing channel narrows in width, thereby geometrically constricting the flow focusing channel. The devices and methods can be utilized in sex-sorting of sperm cells to improve performance and increase eligibility.

A microfabricated sheath flow structure for producing a sheath flow includes a primary sheath flow channel for conveying a sheath fluid, a sample inlet for injecting a sample into the sheath fluid in the primary sheath flow channel, a primary focusing region for focusing the sample within the sheath fluid and a secondary focusing region for providing additional focusing of the sample within the sheath fluid. The secondary focusing region may be formed by a flow channel intersecting the primary sheath flow channel to inject additional sheath fluid into the primary sheath flow channel from a selected direction. A sheath flow system may comprise a plurality of sheath flow structures operating in parallel on a microfluidic chip.

The method includes covering a first opening of at least one first chute using a lid, delivering air from a pressurized air source into the at least one first chute, and advancing at least one first plunger through a first end of the at least one first chute to transfer a product through a second end of the at least one first chute and into a first open side of at least one first box.

A mechanically-controlled vacuum throttle for a continuous dense phase pneumatic conveying system and related method is provided. The system includes a pneumatic conveyance line, a particulate material insertion assembly, a positive displacement blower, a transport fluid intake assembly, and a vacuum throttling assembly. The vacuum throttling assembly is configured to control the flow of air mass density into the blower and through the conveyance line. A portion of the vacuum throttling assembly is tied in to the conveyance line pressure downstream of the blower and adjusts the air mass density flow depending on the downstream pressure. Preferably, the vacuum throttling assembly includes an obstruction element and an opening collar, where the obstruction element is moveable relative to the opening collar and the air mass density flow is adjusted depending on the amount of movement of the obstruction element relative to the opening collar.

A mechanically-controlled vacuum throttle for a continuous dense phase pneumatic conveying system and related method is provided. The system includes a pneumatic conveyance line, a particulate material insertion assembly, a positive displacement blower, a transport fluid intake assembly, and a vacuum throttling assembly. The vacuum throttling assembly is configured to control the flow of air mass density into the blower and through the conveyance line. A portion of the vacuum throttling assembly is tied in to the conveyance line pressure downstream of the blower and adjusts the air mass density flow depending on the downstream pressure. Preferably, the vacuum throttling assembly includes an obstruction element and an opening collar, where the obstruction element is moveable relative to the opening collar and the air mass density flow is adjusted depending on the amount of movement of the obstruction element relative to the opening collar.