A process for the separation of .sup.99mTc from molybdenum targets is described. The method for separation of .sup.99mTc isotope from molybdenum targets includes: i) providing an initial multicomponent mixture of elements, the mixture containing .sup.99mTc; ii) dissolving the multicomponent mixture of elements with an oxidizing agent to oxidize the mixture of elements; iii) heating the mixture of elements at a temperature sufficiently high enough to sublimate a vaporized compound containing .sup.99mTc; iv) condensing the vaporized compound containing .sup.99mTc to form a reaction product; v) adding a base to the condensed reaction product to dissolve the .sup.99mTc containing reaction product to form sodium pertechnetate (Na.sup.99mTcO.sub.4); and vii) purifying the crude solution of sodium pertechnetate Na.sup.99mTc04 using column chromatography to provide the .sup.99mTc isotope as a radiochemical compound.

Provided herein are protein contrast agents and targeted protein contrast agents, formulations thereof, and methods of use, including but not limited to, as a magnetic resonance imaging contrast agent.

Apparatuses and methods for production of molybdenum targets, and the formed molybdenum targets, used to produce Tc-99m are described. The target includes a copper support plate having a front face and a back face. The copper support plate desirably has dimensions of thickness of about 2.8 mm, a length of about 65 mm and a width of about 30 mm; and the copper support plate desirably has either a circular or an elliptical cavity centrally formed therein by pressing molybdenum powder into the front face with a depth of about 200-400 microns. Also, the copper support plate includes cooling channels dispensed at the back face; wherein the copper support plate is water cooled by a flow of water during irradiation by a proton beam. Molybdenum powder is embedded and compressed onto the cavity of the copper support plate thereby creating a thin layer of molybdenum onto the copper support plate.

Provided herein are protein contrast agents and targeted protein contrast agents, formulations thereof, and methods of use, including but not limited to, as a magnetic resonance imaging contrast agent.

Provided herein are protein contrast agents and targeted protein contrast agents, formulations thereof, and methods of use, including but not limited to, as a magnetic resonance imaging contrast agent.

The present disclosure discloses a method for preparing nickel sulfate from ferronickel, including: S1: in a high-pressure oxygen environment, mixing crushed ferronickel with sulfuric acid, introducing a carbon monoxide gas to allow a reaction, and conducting solid-liquid separation (SLS) to obtain a filtrate and a filter residue; S2: adding an oxidizing agent and a precipitating agent successively to the filtrate, controlling a pH of the filtrate, and conducting SLS to obtain a nickel-containing filtrate and an iron hydroxide precipitate; and S3: subjecting the nickel-containing filtrate to extraction and back-extraction to obtain a nickel sulfate solution. In the present disclosure, the carbon monoxide gas is introduced under high-pressure acidic conditions to first react with nickel and iron to form nickel tetracarbonyl and iron pentacarbonyl, and the nickel tetracarbonyl and iron pentacarbonyl are oxidized by oxygen and then smoothly react with sulfuric acid to form nickel sulfate and iron sulfate.

The invention provides a method for preparing a technetium-99m tricarbonyl intermediate. The method comprises reacting a manganese carbonyl compound used as a carbon monoxide source with pertechnetate and water to obtain the technetium-99m tricarbonyl intermediate. The method for preparing a technetium-99m tricarbonyl intermediate in an embodiment of the invention can complete the preparation of the intermediate at atmospheric pressure and room temperature. The method is easy to operate, uses easily obtained raw materials, has a high labeling yield, and can be used to prepare various types of technetium tricarbonyl labeled probes.

A method for preparing alpha sources of polonium. A sample of polonium is provided in a solution. A controlled amount of sulfide and a controlled amount of a metal capable of forming an insoluble sulfide salt in the solution are introduced into the solution, in order to co-precipitate polonium from the solution. The precipitates are filtered out.

A method for preparing alpha sources of polonium. A sample of polonium is provided in a solution. A controlled amount of sulfide and a controlled amount of a metal capable of forming an insoluble sulfide salt in the solution are introduced into the solution, in order to co-precipitate polonium from the solution. The precipitates are filtered out.

Provided herein are protein contrast agents and targeted protein contrast agents, formulations thereof, and methods of use, including but not limited to, as a magnetic resonance imaging contrast agent.