Organic compounds for target identification, drug discovery, chemical library production, high-throughput screening, fluorophore conjugation, chemiluminescent compound conjugation, creation of proximity induced modulators (e.g., protein degraders)/chimeric molecules, or a combination thereof are described. The compounds can contain small molecule moieties for identification of their potential targets; an isocyanate, photoactivatable groups; chemical moieties for enrichment and detection of target-small molecule moiety interactions; proximity induced modulator element; fluorophores; chemiluminescent groups; or combinations thereof.

A compound having an uretonimine group contains, as a structural unit, a carbodiimide compound derived from at least one of an aliphatic diisocyanate and an aromatic diisocyanate, and also contains an isocyanate compound as a structural unit, wherein the residue obtained by removing an isocyanate group from the isocyanate compound and the residue obtained by removing a carbodiimide group from the carbodiimide compound are different.

A compound having an uretonimine group contains, as a structural unit, a carbodiimide compound derived from at least one of an aliphatic diisocyanate and an aromatic diisocyanate, and also contains an isocyanate compound as a structural unit, wherein the residue obtained by removing an isocyanate group from the isocyanate compound and the residue obtained by removing a carbodiimide group from the carbodiimide compound are different.

An alkali metal amide is dissolved in a cyclic alkylene urea represented by the formula (1) (wherein each of R.sub.1 and R.sub.2 represents a C1 to C3 alkyl group, and R.sub.3 represents a C1 to C4 alkylene group).

##STR00001##

An alkali metal amide is dissolved in a cyclic alkylene urea represented by the formula (1) (wherein each of R.sub.1 and R.sub.2 represents a C1 to C3 alkyl group, and R.sub.3 represents a C1 to C4 alkylene group).

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Disclosed is a light colored modified isocyanate mixture and a preparation method thereof. The method comprises the following steps: a) reacting isocyanate groups of a raw material isocyanate under the action of a phospholenecatalyst, and finally obtaining a modified isocyanate reaction solution containing carbodiimide and/or uretonimine derivatives; and b) adding a compounded terminator of a halosilane organic and a sulfonic anhydride to the reaction solution obtained in step a so as to terminate the reaction of carbodiimidization. The modified isocyanate prepared by the method has the characteristics of a liquid state at room temperature, being stable in storage at room temperature and high temperature, and low color number.

Compounds and compositions comprising compounds that modulate pyruvate kinase M2 (PKM2) are described herein. Also described herein are methods of using the compounds that modulate PKM2 in the treatment of cancer.

Disclosed is a light colored modified isocyanate mixture and a preparation method thereof. The method comprises the following steps: a) reacting isocyanate groups of a raw material isocyanate under the action of a phospholenecatalyst, and finally obtaining a modified isocyanate reaction solution containing carbodiimide and/or uretonimine derivatives; and b) adding a compounded terminator of a halosilane organic and a sulfonic anhydride to the reaction solution obtained in step a so as to terminate the reaction of carbodiimidization. The modified isocyanate prepared by the method has the characteristics of a liquid state at room temperature, being stable in storage at room temperature and high temperature, and low color number.

Disclosed herein is a method for analyzing the concentration of a fluorescent compound in the plasma of a patient. The method includes collecting a sample of plasma from a patient, diluting the sample with a solvent and analyzing the diluted sample by HPLC. The sample does not need to be dried down during sample preparation nor is an internal standard required.

A novel compound for a light emitting device, and an organic light emitting device containing the same are disclosed. The compound for a light emitting device is represented by Formula 1 below:

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