A method of preparing a hydrogel product including crosslinked glycosaminoglycan molecules, said method including: i) providing a glycosaminoglycan crosslinked by amide bonds, wherein the crosslinked glycosaminoglycans include residual amine groups; and ii) acylating residual amine groups of the crosslinked glycosaminoglycans provided in i) to form acylated crosslinked glycosaminoglycans.

This invention relates to the flexible packaging, either as sheet, roll, bag, sachet, or other forms, which is biodegradable and edible, and could be used as packaging for solid, semisolid, and liquid, which is featured by the composition of biopolymers, at least two of different natural and renewable biopolymers, and the manufacturing method thereof.

This invention relates to the flexible packaging, either as sheet, roll, bag, sachet, or other forms, which is biodegradable and edible, and could be used as packaging for solid, semisolid, and liquid, which is featured by the composition of biopolymers, at least two of different natural and renewable biopolymers, and the manufacturing method thereof.

A liquid embolic composition of natural polymers, water, and angiographic contrast agents improves neurovascular interventions, making them more reliable, safe, and affordable. The embolic material is made of a single component activated by blood calcium ion, which triggers coagulation, and that offers superior mechanical stability and does not cause fragmentation in the target vessel. The material retains superior long-term mechanical durability after deployment and provides sufficient visualization under fluoroscopy with iodine-based angiographic contrast compounds or other radiopaque compositions. Described herein are aqueous solutions that enable a high concentration gellan gum (greater than 0.5 wt %) to retain sol state even at the range of body temperature (30-40° C.). This discovery means that it is possible to increase the concentration of gellan gum without losing its inject-ability, yet significantly improve its mechanical stability after delivery.

A liquid embolic composition of natural polymers, water, and angiographic contrast agents improves neurovascular interventions, making them more reliable, safe, and affordable. The embolic material is made of a single component activated by blood calcium ion, which triggers coagulation, and that offers superior mechanical stability and does not cause fragmentation in the target vessel. The material retains superior long-term mechanical durability after deployment and provides sufficient visualization under fluoroscopy with iodine-based angiographic contrast compounds or other radiopaque compositions. Described herein are aqueous solutions that enable a high concentration gellan gum (greater than 0.5 wt %) to retain sol state even at the range of body temperature (30-40° C.). This discovery means that it is possible to increase the concentration of gellan gum without losing its inject-ability, yet significantly improve its mechanical stability after delivery.

Process for the preparation of a galacto-oligosaccharide preparation, which process comprises the step of contacting a lactulose-containing feed with a beta-galactosidase derived from Papiliotrema terrestris. The resulting galacto-oligosaccharide is acceptable to subjects suffering from GOS-related allergy and subjects having lactose intolerance.

In some embodiments, the present disclosure pertains to liquid compositions for medical use that comprise (a) a polymer, a monomer, a macromonomer, or a combination of any two or all three of the foregoing and (b) spherical metallic particles, which may comprise, for example, tantalum, tungsten, rhenium, niobium, molybdenum, and alloys of the foregoing. In some embodiments, the present disclosure pertains to medical methods that comprise administering such liquid compositions to a patient. In some embodiments, the present disclosure pertains to use of such liquid compositions as liquid embolics, fiducial markers, tissue-spacing materials, or therapeutic agent depots. In some embodiments, the present disclosure pertains to medical devices that comprise coatings formed from such liquid compositions.

In some embodiments, the present disclosure pertains to liquid compositions for medical use that comprise (a) a polymer, a monomer, a macromonomer, or a combination of any two or all three of the foregoing and (b) spherical metallic particles, which may comprise, for example, tantalum, tungsten, rhenium, niobium, molybdenum, and alloys of the foregoing. In some embodiments, the present disclosure pertains to medical methods that comprise administering such liquid compositions to a patient. In some embodiments, the present disclosure pertains to use of such liquid compositions as liquid embolics, fiducial markers, tissue-spacing materials, or therapeutic agent depots. In some embodiments, the present disclosure pertains to medical devices that comprise coatings formed from such liquid compositions.

A drinking straw comprising an elongate tubular body of an insoluble material having an internal coating comprising a matrix containing an active agent dispersed within the matrix, the body sized to allow a carrier liquid to be drawn therethrough such that passage of the carrier liquid causes the matrix to release the active agent into the carrier liquid to be consumed by a drinker. The matrix comprises partially hydrolysed guar gum, an acid and a modified cellulose. The active agent includes sweetener, flavour, a nutrient and/or a pharmaceutical and optionally colour. The coating is prepared by mixing the matrix with water to form a paste or syrup and is then used to coat the inside surface of a drinking straw to a thickness of less than 1 mm. Liquid drawn through the straw dissolves or breaks down the coating, releasing the active agent into the liquid for consumption.

The present invention provides a resin capable of contributing greatly to solve environmental problems and problems related to exhaustion of fossil fuel resources and having physical properties suited for practical use. The polyester according to the present invention has a diol and a dicarboxylic acid as constituent components and has an amount of terminal acid of 50 equivalents/metric ton or less.