The present disclosure provides reactive quencher dyes that can be used in the detection and/or quantification of desirable target molecules, such as proteins, nucleic acids and various cellular organelles. These dyes are essentially non-fluorescent but are efficient quenchers of various fluorescent dyes. Also, provided are methods of using the dyes, bio-probes incorporating dyes and methods of using the bio-probes. The quencher dyes described herein are modified to provide beneficial properties.

A photochromic mixture including a photochromic material and a thermosetting transparent polymer material, which are uniformly mixed and dissolved in a solvent, is provided. A formation method of a photochromic device based on the photochromic mixture and a light-transmissive head-mounted display device with the photochromic device are further provided. In the photochromic mixture, the change in the structure of the photochromic material under UV light and room light causes a significant change in its absorption spectrum so the color changes. This property is utilized for the benefits: First, the contrast of the head-mounted display device under strong light irradiation is improved. The display effect is enhanced. Second, the damage to human eye by UV light at the natural environment is reduced. Third, under the same optical requirement, the required energy consumption of self-light-emitting elements in the light-transmissive head-mounted display device is correspondingly reduced. It's more energy saving and environmental protecting.

A photochromic mixture including a photochromic material and a thermosetting transparent polymer material, which are uniformly mixed and dissolved in a solvent, is provided. A formation method of a photochromic device based on the photochromic mixture and a light-transmissive head-mounted display device with the photochromic device are further provided. In the photochromic mixture, the change in the structure of the photochromic material under UV light and room light causes a significant change in its absorption spectrum so the color changes. This property is utilized for the benefits: First, the contrast of the head-mounted display device under strong light irradiation is improved. The display effect is enhanced. Second, the damage to human eye by UV light at the natural environment is reduced. Third, under the same optical requirement, the required energy consumption of self-light-emitting elements in the light-transmissive head-mounted display device is correspondingly reduced. It's more energy saving and environmental protecting.

Provided herein are dyes for detecting and distinguishing metals in a sample, as well as compositions and methods comprising the same.

##STR00001## ##STR00002## ##STR00003##

The present invention provides a family of dark quenchers, termed Black Hole Quenchers (BHQs), that are efficient quenchers of excited state energy but which are themselves substantially non-fluorescent. Also provided are methods of using the BHQs, probes incorporating the BHQs and methods of using the probes.

The present invention provides a family of dark quenchers, termed Black Hole Quenchers (BHQs), that are efficient quenchers of excited state energy but which are themselves substantially non-fluorescent. Also provided are methods of using the BHQs, probes incorporating the BHQs and methods of using the probes.

The present disclosure provides reactive quencher dyes that can be used in the detection and/or quantification of desirable target molecules, such as proteins, nucleic acids and various cellular organelles. These dyes are essentially non-fluorescent but are efficient quenchers of various fluorescent dyes. Also, provided are methods of using the dyes, bio-probes incorporating dyes and methods of using the bio-probes. The quencher dyes described herein are modified to provide beneficial properties.

Azo anthrapyridone dye of general formula (III) wherein A, R.sub.1, R.sub.2, B, M and n are as described in the specification, are excellent magenta dyes for dyeing and printing of paper, other cellulose containing materials and textiles materials and, in particular, for the preparation of recording fluids for ink jet printing and for writing utensils.

##STR00001##

The present disclosure provides reactive quencher dyes that can be used in the detection and/or quantification of desirable target molecules, such as proteins, nucleic acids and various cellular organelles. These dyes are essentially non-fluorescent but are efficient quenchers of various fluorescent dyes. Also, provided are methods of using the dyes, bio-probes incorporating dyes and methods of using the bio-probes. The quencher dyes described herein are modified to provide beneficial properties.

The present disclosure provides reactive quencher dyes that can be used in the detection and/or quantification of desirable target molecules, such as proteins, nucleic acids and various cellular organelles. These dyes are essentially non-fluorescent but are efficient quenchers of various fluorescent dyes. Also, provided are methods of using the dyes, bio-probes incorporating dyes and methods of using the bio-probes. The quencher dyes described herein are modified to provide beneficial properties.