A dry consumable preparation and related methods are disclosed. The preparation has a plurality of excipient particles and at least one of a cannabinoid and a cannabinoid extract, the at least one of the cannabinoid or the cannabinoid extract containing one or more cannabinoids plated to the plurality of excipient particles. The preparation further comprises an effervescence agent, the effervescence agent comprising a carbonate salt, and at least one acid. The carbonate salt comprises sodium, potassium and/or calcium. The at least one acid comprises at least one of citric acid, tartaric acid, lactic, acetic, benzoic, ascorbic, oxalic, tannic, phosphoric, or malic acid. A ratio of the at least one of the carbonate salt to the at least one acid is at least 1:1, the ratio configured to create a chemical pH buffering system at a targeted pH range when the dry consumable preparation is added to a targeted amount of water.

Topical formulations of proteases, devices including the formulations are disclosed. Described herein are packages for storing and dispensing multi-part topical enzyme formulations and neutralizing agent, wherein the contents of the parts are mixed, and the enzyme is taken into solution containing a neutralizing agent (skin protectant) for treatment of skin abrasions and disorders. Particular multi-part topical formulation disclosed here relates to immediate (neutralizing agent) and extended relief (enzymes) from itching and inflammation associated with insect stings, insect bites, contact dermatitis such as poison ivy and poison oak, and eczema. The formulations and packaging using this principle and methods of use thereof are also provided. Additionally this invention contains active ingredients for wound cleaning and debridement.

Radioprotection, Radiomitigation and Radiorecovery: Timed use of more widely available antiradiation agents in a kit for subjects affected by ionizing radiation, radiomimetic exposure and radio contamination. The method in the form of strategically timed preemptive and post-irradiation compositions; radioprotection, radiomitigation and radiorecovery formulations are comprised of various available anticorporation, antioxidant, decorporation, multi-mechanistic, pro-survival, pro-hematopoietic, anti-fibrotic and other novel ingredients in synergistic mixtures to be used in critically-timed manners. Radioprotection, radiomitigation and radiorecovery of a mammal prior to, during, just after or well-after exposure to ionizing radiation energy—alpha, beta, neutron, gamma, X-ray and damaging radiofrequency radiation—for long or short periods of time, and exposure to or contamination by radioactive elements or compounds such as radioiodine, radiostrontium, radiophosphorus, radiocobalt, radiocadmium, radiopollonium, radioradium, radiocesium, radiouranium, radioamericium, radiopollonium, radiocerium, radioindium, and the like. Radiomimetic protective method for mucosal exposure is also described.

The present invention is directed to novel systems and methods for treating dermal inflammatory disorders, such as psoriasis.

Radioprotection, Radiomitigation and Radiorecovery: Timed use of more widely available antiradiation agents in a kit for subjects affected by ionizing radiation, radiomimetic exposure and radiocontamination. The method in the form of strategically timed preemptive and postirradiation compositions; radioprotection, radiomitigation and radiorecovery formulations are comprised of various available anticorporation, antioxidant, decorporation, multi-mechanistic, pro-survival, pro-hematopoietic, anti-fibrotic and other novel ingredients in synergistic mixtures to be used in critically-timed manners. Radioprotection, radiomitigation and radiorecovery of a mammal prior to, during, just after or well-after exposure to ionizing radiation energyalpha, beta, neutron, gamma, X-ray and damaging radiofrequency radiationfor long or short periods of time, and exposure to or contamination by radioactive elements or compounds such as radioiodine, radiostrontium, radiophosphorus, radiocobalt, radiocadmium, radiopollonium, radioradium, radiocesium, radiouranium, radioamericium, radiopollonium, radiocerium, radioindium, and the like. Radiomimeticprotective method for mucosal exposure is also described.

The present invention provides methods for treating skin cancers utilizing pharmaceutical formulations in the form of a hydrogel that includes a proteolytic enzyme mixture obtained from bromelain and a water-soluble gelling agent. In particular, the method is useful for treating non-melanoma skin cancers, pre-cancerous skin lesions, and benign skin lesions.

The present invention is directed to novel systems and methods for treating dermal inflammatory disorders, such as psoriasis.

Disclosed are compositions and methods useful for improving blood cholesterol profiles in a mammal, particularly for improving metabolism of cholesterol, for reducing the levels of low-density lipoprotein cholesterol (LDL-C) in the blood, increasing the levels of high-density lipoprotein (HDL-C) in the blood, for improving weight loss in a mammal, and/or for enhancing overall cardiovascular health in a mammal. Methods can involve identifying a mammal in need of lowering of blood LDL-C and/or triglyceride concentrations, and administering to said mammal a specific formulation consisting of a blend of probiotics; specifically, Bifidobacterium infantis, Bifidobacterium bifidum, Lactobacillus acidophilus, Lactobacillus salivarius, Lactobacillus plantarum, Lactobacillus rhamnosus, Bifidobacterium longum, Lactobacillus casei, Lactobacillus paracasei, in combination with a blend of digestive enzymes; specifically, amylase, glucoamylase, lipase, bromelain, maltase, lactase, hemicellulase, xylanase, papain, and invertase. Preferably, the aforementioned probiotics and digestive enzymes are combined into capsules and administered to said mammal three times daily to achieve said lowering of LDL-C and triglyceride concentrations in blood.

The present disclosure relates to a compound and method of using such compound, preferably in the form of a dietary supplement that, when administered, is capable of treating thyroid disease and various thyroid-related disorders, such as Hashimoto's thyroiditis. The unique combination of the composition is preferably administered orally via acid resistant or enteric-coated capsule, soft gel or tablet. The composition is preferably comprised of at least Catalase, Reduced Glutathione, Acetylated Glutathione, DPP-IV protease enzyme, Pepsin, Bromelain, Pancreatin, Vitamin D, and Selenium. The composition can further comprise a palliative agent, and can be provided in specific dosages or administered in forms besides those listed above.

Compositions containing bromelain are disclosed for use as topical therapeutic agents for the treatment of rosacea. The compositions include lotions, creams and ointments.