Topical formulations of proteases, devices including the formulations are disclosed. Described herein are packages for storing and dispensing multi-part topical enzyme formulations and neutralizing agent, wherein the contents of the parts are mixed, and the enzyme is taken into solution containing a neutralizing agent (skin protectant) for treatment of skin abrasions and disorders. Particular multi-part topical formulation disclosed here relates to immediate (neutralizing agent) and extended relief (enzymes) from itching and inflammation associated with insect stings, insect bites, contact dermatitis such as poison ivy and poison oak, and eczema. The formulations and packaging using this principle and methods of use thereof are also provided. Additionally this invention contains active ingredients for wound cleaning and debridement.

Radioprotection, Radiomitigation and Radiorecovery: Timed use of more widely available antiradiation agents in a kit for subjects affected by ionizing radiation, radiomimetic exposure and radio contamination. The method in the form of strategically timed preemptive and post-irradiation compositions; radioprotection, radiomitigation and radiorecovery formulations are comprised of various available anticorporation, antioxidant, decorporation, multi-mechanistic, pro-survival, pro-hematopoietic, anti-fibrotic and other novel ingredients in synergistic mixtures to be used in critically-timed manners. Radioprotection, radiomitigation and radiorecovery of a mammal prior to, during, just after or well-after exposure to ionizing radiation energy—alpha, beta, neutron, gamma, X-ray and damaging radiofrequency radiation—for long or short periods of time, and exposure to or contamination by radioactive elements or compounds such as radioiodine, radiostrontium, radiophosphorus, radiocobalt, radiocadmium, radiopollonium, radioradium, radiocesium, radiouranium, radioamericium, radiopollonium, radiocerium, radioindium, and the like. Radiomimetic protective method for mucosal exposure is also described.

The present invention is directed to novel systems and methods for treating dermal inflammatory disorders, such as psoriasis.

Radioprotection, Radiomitigation and Radiorecovery: Timed use of more widely available antiradiation agents in a kit for subjects affected by ionizing radiation, radiomimetic exposure and radiocontamination. The method in the form of strategically timed preemptive and postirradiation compositions; radioprotection, radiomitigation and radiorecovery formulations are comprised of various available anticorporation, antioxidant, decorporation, multi-mechanistic, pro-survival, pro-hematopoietic, anti-fibrotic and other novel ingredients in synergistic mixtures to be used in critically-timed manners. Radioprotection, radiomitigation and radiorecovery of a mammal prior to, during, just after or well-after exposure to ionizing radiation energyalpha, beta, neutron, gamma, X-ray and damaging radiofrequency radiationfor long or short periods of time, and exposure to or contamination by radioactive elements or compounds such as radioiodine, radiostrontium, radiophosphorus, radiocobalt, radiocadmium, radiopollonium, radioradium, radiocesium, radiouranium, radioamericium, radiopollonium, radiocerium, radioindium, and the like. Radiomimeticprotective method for mucosal exposure is also described.

Disclosed are liposomal supplement compositions and methods of formulating the same. A liposomal composition includes a nutraceutical compound such as cannabidiol (CBD), a proteolytic enzyme component such as papain and/or bromelain, and a phytochemical component such as piceatannol. These components are encapsulated within liposomes for enhanced bioavailability and effectiveness.

Provided are methods for reducing or eliminating allergenicity of legumes, peanuts, or tree nuts, comprising contacting allergenic proteins embedded in seeds, or pieces thereof, of legumes, peanuts, or tree nuts with an aqueous solution of bromelain in an amount and for a time period sufficient to reduce or eliminate the allergenicity of the allergenic proteins (Ara h1, and/or Ara h2, and/or Ara h3 allergen). Additionally provided are methods for decontaminating machinery contaminated with allergenic proteins (Ara h1, and/or Ara h2, and/or Ara h3 allergen) or allergen residues thereof, comprising contacting the contaminated machinery with an aqueous solution of bromelain in an amount and for a time period sufficient to reduce or eliminate the allergenicity of the allergenic proteins.

The present invention is directed to novel systems and methods for treating dermal inflammatory disorders, such as psoriasis.

The present disclosure relates to an additive for treating beverages made from plant musts, particularly wine, beer, cider or fruit juices, and more particularly for improving the quality of such beverages, namely, for example, protein stability and for avoiding the cloudiness of such beverages. In its broadest application, such an additive includes a cysteine protease and a cofactor.

The present disclosure relates to a compound and method of using such compound, preferably in the form of a dietary supplement that, when administered, is capable of treating thyroid disease and various thyroid-related disorders, such as Hashimoto's thyroiditis. The unique combination of the composition is preferably administered orally via acid resistant or enteric-coated capsule, soft gel or tablet. The composition is preferably comprised of at least Catalase, Reduced Glutathione, Acetylated Glutathione, DPP-IV protease enzyme, Pepsin, Bromelain, Pancreatin, Vitamin D, and Selenium. The composition can further comprise a palliative agent, and can be provided in specific dosages or administered in forms besides those listed above.

Compositions containing bromelain are disclosed for use as topical therapeutic agents for the treatment of rosacea. The compositions include lotions, creams and ointments.