A glass vial includes a base including a boron-containing multicomponent glass and a vial opening and holds a liquid active pharmaceutical ingredient formulation. The glass vial has a total volume of <4.5 mL. A filling level of the glass vial with the active pharmaceutical ingredient formulation is not more than 0.25 and a concentration of boron ions, measured at a measurement site below a plane of a middle of the glass vial using a concentration depth profile at a depth in a range from 10 to 30 nm, has a value, averaged over the measurements of the concentration depth profile, that has an excess increase of not more than 30% compared to a concentration of boron ions measured using a concentration depth profile at a depth in a range from 10 to 30 nm with a measurement site in the plane of the middle of the glass vial.

A glass vial includes a base including a boron-containing multicomponent glass and a vial opening and holds a liquid active pharmaceutical ingredient formulation. The glass vial has a total volume of <4.5 mL. A filling level of the glass vial with the active pharmaceutical ingredient formulation is not more than 0.25 and a concentration of boron ions, measured at a measurement site below a plane of a middle of the glass vial using a concentration depth profile at a depth in a range from 10 to 30 nm, has a value, averaged over the measurements of the concentration depth profile, that has an excess increase of not more than 30% compared to a concentration of boron ions measured using a concentration depth profile at a depth in a range from 10 to 30 nm with a measurement site in the plane of the middle of the glass vial.

The present invention relates to a glass including, in terms of mole percentage based on oxides: SiO.sub.2 in an amount of 45% to 65%; Al.sub.2O.sub.3 in an amount of 18% to 30%; Li.sub.2O in an amount of 7% to 15%; one or more selected from Y.sub.2O.sub.3 and La.sub.2O.sub.3 in a total amount of 0% to 10%; P.sub.2O.sub.5 in an amount of 0% to 10%; B.sub.2O.sub.3 in an amount of 0% to 10%; and ZrO.sub.2 in an amount of 0% to 4%, and satisfying the following expression: [Al.sub.2O.sub.3]—[R.sub.2O]—[RO]—[P.sub.2O.sub.5]>0, provided that, in terms of mole percentage based on oxides, a content of Al.sub.2O.sub.3 is defined as [Al.sub.2O.sub.3], a content of P.sub.2O.sub.5 is defined as [P.sub.2O.sub.5], a total content of alkali metal oxides is defined as [R.sub.2O], and a total content of alkali earth metal oxides is defined as [RO].

The present invention relates to a glass including, in terms of mole percentage based on oxides: SiO.sub.2 in an amount of 45% to 65%; Al.sub.2O.sub.3 in an amount of 18% to 30%; Li.sub.2O in an amount of 7% to 15%; one or more selected from Y.sub.2O.sub.3 and La.sub.2O.sub.3 in a total amount of 0% to 10%; P.sub.2O.sub.5 in an amount of 0% to 10%; B.sub.2O.sub.3 in an amount of 0% to 10%; and ZrO.sub.2 in an amount of 0% to 4%, and satisfying the following expression: [Al.sub.2O.sub.3]—[R.sub.2O]—[RO]—[P.sub.2O.sub.5]>0, provided that, in terms of mole percentage based on oxides, a content of Al.sub.2O.sub.3 is defined as [Al.sub.2O.sub.3], a content of P.sub.2O.sub.5 is defined as [P.sub.2O.sub.5], a total content of alkali metal oxides is defined as [R.sub.2O], and a total content of alkali earth metal oxides is defined as [RO].

A glass includes: a plurality of components (in wt.-%) as follows:

TABLE-US-00001 Component Proportion (% by weight) SiO.sub.2 50-80  Al.sub.2O.sub.3 0-10 B.sub.2O.sub.3 0-15 Li.sub.2O 0-20 Na.sub.2O 0-20 K.sub.2O 0-25 BaO 0-10 CaO 0-10 MgO 0-10 ZnO 0-10 La.sub.2O.sub.3 0-20 TiO.sub.2 0-5  Cl 0-3  MnO.sub.2 0.2-5.0  Cr.sub.2O.sub.3 0.05-3.0,.sup. 
a sum of a plurality of proportions of Li.sub.2O, Na.sub.2O and K.sub.2O being in a range of from 5.0 to 30.0 wt.-%, a sum of a plurality of amounts of MnO.sub.2 and Cr.sub.2O.sub.3 being at least 0.3 wt.-%, and a ratio of a plurality of proportions of MnO.sub.2 (in wt.-%) and Cr.sub.2O.sub.3 (in wt.-%) being in a range of from 1.5:1 to 12.5:1.

A glass includes: a plurality of components (in wt.-%) as follows:

TABLE-US-00001 Component Proportion (% by weight) SiO.sub.2 50-80  Al.sub.2O.sub.3 0-10 B.sub.2O.sub.3 0-15 Li.sub.2O 0-20 Na.sub.2O 0-20 K.sub.2O 0-25 BaO 0-10 CaO 0-10 MgO 0-10 ZnO 0-10 La.sub.2O.sub.3 0-20 TiO.sub.2 0-5  Cl 0-3  MnO.sub.2 0.2-5.0  Cr.sub.2O.sub.3 0.05-3.0,.sup. 
a sum of a plurality of proportions of Li.sub.2O, Na.sub.2O and K.sub.2O being in a range of from 5.0 to 30.0 wt.-%, a sum of a plurality of amounts of MnO.sub.2 and Cr.sub.2O.sub.3 being at least 0.3 wt.-%, and a ratio of a plurality of proportions of MnO.sub.2 (in wt.-%) and Cr.sub.2O.sub.3 (in wt.-%) being in a range of from 1.5:1 to 12.5:1.

Bulk paint and ceramic powder systems, methods of forming same, and methods of forming a flexible ceramic coating on a metal substrate are disclosed. The systems may include a ceramic composition having between 2 to 30 weight percent of an alkali metal oxide, such as K.sub.2O, Na.sub.2O, and Li.sub.2O or mixtures thereof, between 10 to 74 weight percent SiO.sub.2, and between 23 to 79 weight percent B.sub.2O.sub.3. Additives that are nonwetting with molten metals, such as boron nitride, provide durable coatings for metal processing operations. The ceramic composition may include less than 5 weight percent additional metal oxides. The bulk paint system further may include water and a cellulosic suspension agent to form a bulk paint. The ceramic powder system may be processed to form a uniform powder. The bulk paint or uniform powder may be applied to a metal substrate, such as a ferrous metal substrate, dried, and heated to form a flexible coating on the metal substrate.

Bulk paint and ceramic powder systems, methods of forming same, and methods of forming a flexible ceramic coating on a metal substrate are disclosed. The systems may include a ceramic composition having between 2 to 30 weight percent of an alkali metal oxide, such as K.sub.2O, Na.sub.2O, and Li.sub.2O or mixtures thereof, between 10 to 74 weight percent SiO.sub.2, and between 23 to 79 weight percent B.sub.2O.sub.3. Additives that are nonwetting with molten metals, such as boron nitride, provide durable coatings for metal processing operations. The ceramic composition may include less than 5 weight percent additional metal oxides. The bulk paint system further may include water and a cellulosic suspension agent to form a bulk paint. The ceramic powder system may be processed to form a uniform powder. The bulk paint or uniform powder may be applied to a metal substrate, such as a ferrous metal substrate, dried, and heated to form a flexible coating on the metal substrate.

A vacuum insulated structure for use in an appliance includes an inner liner and an outer wrapper coupled to the inner liner. A vacuum insulated cavity is defined therebetween. An insulation material is disposed in the vacuum insulated cavity. The insulation material includes porous glass flakes.

The present invention provides a highly reliable multilayered glass panel and an encapsulating material for achieving the highly reliable multilayered glass panel. The encapsulating material includes lead-free low melting glass particles containing vanadium oxide and tellurium oxide, low thermal expansion filler particles, and glass beads as a solid content. A volume fraction of the glass beads in the solid content is not less than 10% to not more than 35%, and a volume fraction of the lead-free low melting glass particles in the solid content is larger than a volume fraction of the low thermal expansion filler in the solid content.