C07C29/40

Preparation of Grignard reagents using a fluidized bed

The present invention relates to a process of preparing a Grignard reagent comprising reacting magnesium particulates in a fluid bed reactor. The present invention further relates to a continuous process comprising fluidizing magnesium particulates in a reactor, forming the Grignard reagent continuously, and reacting the Grignard reagent with a substrate.

Preparation of Grignard reagents using a fluidized bed

The present invention relates to a process of preparing a Grignard reagent comprising reacting magnesium particulates in a fluid bed reactor. The present invention further relates to a continuous process comprising fluidizing magnesium particulates in a reactor, forming the Grignard reagent continuously, and reacting the Grignard reagent with a substrate.

Process for the preparation of α-alkyl-2-(trifluoromethyl)-benzyl alcohols

The present invention relates to a process for the preparation of preparation -alkyl-2-(trifluoromethyl)-benzyl alcohol.

Process for the preparation of α-alkyl-2-(trifluoromethyl)-benzyl alcohols

The present invention relates to a process for the preparation of preparation -alkyl-2-(trifluoromethyl)-benzyl alcohol.

Process for preparation of intermediates

Disclosed herein is a process for preparation of 1-chloro-2-(1-chlorocyclopropyl)-3-(2-chlorophenyl)propan-2-ol (compound of formula (I)) and 2-(1-chlorocyclopropyl)-2-[(2-chlorophenyl)methyl]oxirane (compound of formula (II)), which are synthetic intermediates in the preparation of triazole fungicides. The process comprises reacting a Grignard reagent of 2-chlorobenzyl halide with 1-chloro-1-chloroacetylcyclopropane, wherein said reaction is carried out at temperatures between 0 C. and 100 C. and characterized in that said reaction is carried out in a solvent system comprising methyl tetrahydrofuran and toluene.

Process for preparation of intermediates

Disclosed herein is a process for preparation of 1-chloro-2-(1-chlorocyclopropyl)-3-(2-chlorophenyl)propan-2-ol (compound of formula (I)) and 2-(1-chlorocyclopropyl)-2-[(2-chlorophenyl)methyl]oxirane (compound of formula (II)), which are synthetic intermediates in the preparation of triazole fungicides. The process comprises reacting a Grignard reagent of 2-chlorobenzyl halide with 1-chloro-1-chloroacetylcyclopropane, wherein said reaction is carried out at temperatures between 0 C. and 100 C. and characterized in that said reaction is carried out in a solvent system comprising methyl tetrahydrofuran and toluene.