The invention relates to compounds of formula (A) as defined herein, and esters of the compound of formula (A), and ketones of the compound of formula (A). The invention further relates to a method for preparing compounds of formula (A) and esters of the compound of formula (A), and ketones of the compound of formula (A). The invention further relates to the use of at least one compound selected from compounds of formula (A) and the esters of a compound of formula (A) and the ketones of a compound of formula (A) as aroma chemical.

The invention relates to compounds of formula (A) as defined herein, and esters of the compound of formula (A), and ketones of the compound of formula (A). The invention further relates to a method for preparing compounds of formula (A) and esters of the compound of formula (A), and ketones of the compound of formula (A). The invention further relates to the use of at least one compound selected from compounds of formula (A) and the esters of a compound of formula (A) and the ketones of a compound of formula (A) as aroma chemical.

The invention relates to compounds of formula (A) as defined herein, and esters of the compound of formula (A), and ketones of the compound of formula (A). The invention further relates to a method for preparing compounds of formula (A) and esters of the compound of formula (A), and ketones of the compound of formula (A). The invention further relates to the use of at least one compound selected from compounds of formula (A) and the esters of a compound of formula (A) and the ketones of a compound of formula (A) as aroma chemical.

The present disclosure provides processes for preparing (+)-pleuromutilin and synthetic (+)-pleuromutilin produced therefrom. Also provided are intermediates prepared thereby and processes for preparing these intermediates.

The present disclosure provides processes for preparing (+)-pleuromutilin and synthetic (+)-pleuromutilin produced therefrom. Also provided are intermediates prepared thereby and processes for preparing these intermediates.

Processes for stereoselective preparation of a chiral alcohol or a chiral amine are described. The processes include reacting a first prochiral reactant selected from the group consisting of a ketone, an aldehyde, and an imine, with a second reactant that includes a Grignard reagent, in the presence of a chiral trans-diamine of formula (1) as defined herein: ##STR00001##

Processes for stereoselective preparation of a chiral alcohol or a chiral amine are described. The processes include reacting a first prochiral reactant selected from the group consisting of a ketone, an aldehyde, and an imine, with a second reactant that includes a Grignard reagent, in the presence of a chiral trans-diamine of formula (1) as defined herein: ##STR00001##

Processes for stereoselective preparation of a chiral alcohol or a chiral amine are described. The processes include reacting a first prochiral reactant selected from the group consisting of a ketone, an aldehyde, and an imine, with a second reactant that includes a Grignard reagent, in the presence of a chiral trans-diamine of formula (1) as defined herein: ##STR00001##

An inexpensive, stereoselective synthesis for nootkatone, tetrahydronootkatone, and their derivatives is disclosed utilizing ozonolysis. The starting materials used in the synthesis are inexpensive and the reactions are commercially feasible and amenable to scaling up. The principal starting material, ()--Pinene, is on the GRAS list (generally recognized as safe).

An inexpensive, stereoselective synthesis for nootkatone, tetrahydronootkatone, and their derivatives is disclosed utilizing ozonolysis. The starting materials used in the synthesis are inexpensive and the reactions are commercially feasible and amenable to scaling up. The principal starting material, ()--Pinene, is on the GRAS list (generally recognized as safe).