Suggested is a process for the production of solid cooling agents, wherein a pre-scraped melt, i.e., a melt of menthol compounds with added seed crystals is applied to a pre-cooled area by even deposition of drops.

Suggested is a process for the production of solid cooling agents, wherein a pre-scraped melt, i.e., a melt of menthol compounds with added seed crystals is applied to a pre-cooled area by even deposition of drops.

A process for producing L-menthol in solid form, including the following steps: providing a menthol melt, feeding the melt to a drop former having a rotating, perforated outer drum and a fixed nozzle strip adjacent to the inside of the outer drum, depositing the menthol melt produced by the drop former onto a continuous cooling belt, solidifying the menthol melt during transport on the cooling belt to form L-menthol pellets and taking the pellets off in the region of a deflection drum for the cooling belt.

A process for producing L-menthol in solid form, including the following steps: providing a menthol melt, feeding the melt to a drop former having a rotating, perforated outer drum and a fixed nozzle strip adjacent to the inside of the outer drum, depositing the menthol melt produced by the drop former onto a continuous cooling belt, solidifying the menthol melt during transport on the cooling belt to form L-menthol pellets and taking the pellets off in the region of a deflection drum for the cooling belt.

A process for producing L-menthol in solid form, including the following steps: providing a menthol melt, feeding the melt to a drop former having a rotating, perforated outer drum and a fixed nozzle strip adjacent to the inside of the outer drum, depositing the menthol melt produced by the drop former onto a continuous cooling belt, solidifying the menthol melt during transport on the cooling belt to form L-menthol pellets and taking the pellets off in the region of a deflection drum for the cooling belt.

Disclosed is an adduct between a Lewis acid, preferably aluminum trichloride, iron trichloride, or zinc dichloride, and a hydrosilane;a method for preparing same; and a method for for reducing, particularly, an aldehyde, a ketone, an ,-unsaturated ketone, an imine, or an ,-unsaturated imine.

Disclosed is an adduct between a Lewis acid, preferably aluminum trichloride, iron trichloride, or zinc dichloride, and a hydrosilane;a method for preparing same; and a method for for reducing, particularly, an aldehyde, a ketone, an ,-unsaturated ketone, an imine, or an ,-unsaturated imine.

This invention relates to cocrystals of naloxone and of naltrexone and their use as opioid antagonists. The cocrystals of the invention include naloxone isonicotinamide cocrystal, naloxone hydrochloride piperazine cocrystal, naltrexone menthol cocrystal, naltrexone thymine cocrystal, naltrexone 2,5-dihydroxybenzoic acid cocrystal, naltrexone salicylic acid cocrystal, naltrexone hydrochloride piperazine cocrystal and naltrexone hydrochloride sulfathiazole cocrystal. A drug-in adhesive transdermal patch containing the opioid analgesic fentanyl or an analog thereof and a cocrystal of naloxone or naltrexone is disclosed. Also disclosed is a method of treating pain, such as acute, chronic or intermittent pain, by applying a drug-in-adhesive transdermal patch of the invention to the skin of a patient in need thereof. Also disclosed is an improved transdermal patch for administering fentanyl or an analog thereof, or for administering a mu opioid agonist, the improvement wherein the transdermal patch contains a cocrystal of the invention in an abuse limiting amount. The improved transdermal patch may be a drug-in-adhesive transdermal patch or a reservoir transdermal patch.

This invention relates to cocrystals of naloxone and of naltrexone and their use as opioid antagonists. The cocrystals of the invention include naloxone isonicotinamide cocrystal, naloxone hydrochloride piperazine cocrystal, naltrexone menthol cocrystal, naltrexone thymine cocrystal, naltrexone 2,5-dihydroxybenzoic acid cocrystal, naltrexone salicylic acid cocrystal, naltrexone hydrochloride piperazine cocrystal and naltrexone hydrochloride sulfathiazole cocrystal. A drug-in adhesive transdermal patch containing the opioid analgesic fentanyl or an analog thereof and a cocrystal of naloxone or naltrexone is disclosed. Also disclosed is a method of treating pain, such as acute, chronic or intermittent pain, by applying a drug-in-adhesive transdermal patch of the invention to the skin of a patient in need thereof. Also disclosed is an improved transdermal patch for administering fentanyl or an analog thereof, or for administering a mu opioid agonist, the improvement wherein the transdermal patch contains a cocrystal of the invention in an abuse limiting amount. The improved transdermal patch may be a drug-in-adhesive transdermal patch or a reservoir transdermal patch.

The present invention relates to a process for the preparation of an optically active carbonyl compound by asymmetric hydrogenation of a prochiral ,-unsaturated carbonyl compound with hydrogen in the presence of at least one optically active transition metal catalyst that is soluble in the reaction mixture and which has rhodium as catalytically active transition metal and a chiral, bidentate bisphosphine ligand, wherein the reaction mixture during the hydrogenation of the prochiral ,-unsaturated carbonyl compound additionally comprises at least one compound of the general formula (I):

##STR00001## in which R.sup.1, R.sup.2: are identical or different and are C.sub.6- to C.sub.10-aryl which is unsubstituted or carries one or more, e.g. 1, 2, 3, 4 or 5, substituents which are selected from C.sub.1- to C.sub.6-alkyl, C.sub.3- to C.sub.6-cycloalkyl, C.sub.6- to C.sub.10-aryl, C.sub.1- to C.sub.6-alkoxy and amino; Z is a group CHR.sup.3R.sup.4 or aryl which is unsubstituted or carries one or more, e.g. 1, 2, 3, 4 or 5, substituents which are selected from C.sub.1- to C.sub.6-alkyl, C.sub.3- to C.sub.6-cycloalkyl, C.sub.6- to C.sub.10-aryl, C.sub.1- to C.sub.6-alkoxy and amino, wherein R.sup.3 and R.sup.4 are as defined in the claims and the description.