The invention relates to a method for separating natural substance mixtures, in particular those consisting of plant extracts, and for isolating and purifying and obtaining same, by means of sequential centrifugal partition chromatography (sCPC).

Processes for making phenol and xylenes from a phenols-containing feed are described. The processes involve transalkylation of alkylphenols to form phenol and alkylbenzenes. The phenol is separated from the alkylbenzenes, and the alkylbenzenes may be separated into benzene, toluene, xylenes, and heavy alkylbenzene streams. The benzene stream may be recycled to the transalkylation reaction zone. The toluene may be sent to a disproportionation reaction zone, and the product is sent back to the aromatic separation zone. The toluene can also be recycled to the transalkylation zone. The xylenes are separated into a p-xylene stream and a mixed xylene stream comprising m-xylene and o-xylene. The mixed xylene stream is isomerized and the isomerized product is sent back to the aromatic separation zone. The heavy alkylbenzenes are dealkylated and separated, with the aromatic stream being recycled to the aromatic separation zone.

Processes for making phenol and xylenes from a phenols-containing feed are described. The processes involve transalkylation of alkylphenols to form phenol and alkylbenzenes. The phenol is separated from the alkylbenzenes, and the alkylbenzenes may be separated into benzene, toluene, xylenes, and heavy alkylbenzene streams. The benzene stream may be recycled to the transalkylation reaction zone. The toluene may be sent to a disproportionation reaction zone, and the product is sent back to the aromatic separation zone. The toluene can also be recycled to the transalkylation zone. The xylenes are separated into a p-xylene stream and a mixed xylene stream comprising m-xylene and o-xylene. The mixed xylene stream is isomerized and the isomerized product is sent back to the aromatic separation zone. The heavy alkylbenzenes are dealkylated and separated, with the aromatic stream being recycled to the aromatic separation zone.

A method for purification and extraction of cannabinoids includes: providing a cannabis oil including phospholipids and cannabinoid acids; contacting the cannabis oil with a degumming solvent, wherein the degumming solvent and cannabis oil are substantially immiscible; and separating an aqueous phase including the degumming solvent and at least a portion of the phospholipids from an oil phase including the cannabis oil. The method may further include contacting the oil phase with an extraction solvent, where the extraction solvent and oil phase are substantially immiscible; and separating an aqueous phase including the extraction solvent and at least a portion of the cannabinoid acids from a second oil solvent phase including the oil phase and/or simply the liberated cannabinoids following acidification of the extraction solvent.

A method for purification and extraction of cannabinoids includes: providing a cannabis oil including phospholipids and cannabinoid acids; contacting the cannabis oil with a degumming solvent, wherein the degumming solvent and cannabis oil are substantially immiscible; and separating an aqueous phase including the degumming solvent and at least a portion of the phospholipids from an oil phase including the cannabis oil. The method may further include contacting the oil phase with an extraction solvent, where the extraction solvent and oil phase are substantially immiscible; and separating an aqueous phase including the extraction solvent and at least a portion of the cannabinoid acids from a second oil solvent phase including the oil phase and/or simply the liberated cannabinoids following acidification of the extraction solvent.

Various aspects of the disclosure relate to 2-[(1R,6R)-6-isopropenyl-3-methylcyclohex-2-en-1-yl]-3-hydroxy-5-pentylphenolate and compositions comprising 2-[(1R,6R)-6-isopropenyl-3-methylcyclohex-2-en-1-yl]-3-hydroxy-5-pentylphenolate.

Various aspects of the disclosure relate to 2-[(1R,6R)-6-isopropenyl-3-methylcyclohex-2-en-1-yl]-3-hydroxy-5-pentylphenolate and compositions comprising 2-[(1R,6R)-6-isopropenyl-3-methylcyclohex-2-en-1-yl]-3-hydroxy-5-pentylphenolate.

A method is provided for removing THC from raw Cannabis oil. Additionally, new compositions of Cannabis oil are provided. Further, a new method of obtaining a substantially pure cannabinoid is provided

A method is provided for removing THC from raw Cannabis oil. Additionally, new compositions of Cannabis oil are provided. Further, a new method of obtaining a substantially pure cannabinoid is provided

A process for the synthesis of Cannabidiol of formula (1): (1) is herein disclosed. The process comprises contacting a solution [solution (S1)] of (+)-p-mentha-diene-3-ol of formula (4) (4) or an ester thereof and olivetol of formula (3): (3) with a solution [solution (S2)] of a non-supported Lewis acid in a continuous flow reactor and treatment of the resulting mixture with a basic solution. The process offers the advantage that it can be conveniently carried out on an industrial scale while avoiding the formation of abnormal CBD and THC (Δ9-tetrahydrocannabinol).

##STR00001##